Prostaglandin D₂ inhibits the production of interleukin‐12 in murine dendritic cells through multiple signaling pathways

Dendritic cells and the control of immunity

1998 • 14,345 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Prostanoid Receptors: Structures, Properties, and Functions

1999 • 2,395 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

2000 • 1,337 citations

Inducible cyclooxygenase may have anti-inflammatory properties

1999 • 1,246 citations

Pro‐inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum‐free conditions

1997 • 1,179 citations

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

2001 • 1,072 citations

15-Deoxy-Δ ^12,14 -prostaglandin J ₂ inhibits multiple steps in the NF-κB signaling pathway

2000 • 1,014 citations

Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

2002 • 846 citations

Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

2001 • 733 citations

Prostaglandin D ₂ as a Mediator of Allergic Asthma

2000 • 731 citations

Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

2001 • 692 citations

IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells.

1997 • 615 citations

Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

1995 • 495 citations

15-Deoxy-Δ12,14-prostaglandin J2

2002 • 393 citations

The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics

2001 • 390 citations

Prostaglandin E2 Induces the Final Maturation of IL-12-Deficient CD1a+CD83+ Dendritic Cells: The Levels of IL-12 Are Determined During the Final Dendritic Cell Maturation and Are Resistant to Further Modulation

1998 • 379 citations

Prostaglandin E2 is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer

2001 • 369 citations

Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

2001 • 328 citations

Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription.

1997 • 320 citations

Cyclic Nucleotide-Dependent Protein Kinases: Intracellular Receptors for cAMP and cGMP Action

1999 • 306 citations

Prostaglandin D synthase: Structure and function

2000 • 294 citations

Prostaglandin E2 and Tumor Necrosis Factor α Cooperate to Activate Human Dendritic Cells: Synergistic Activation of Interleukin 12 Production

1997 • 281 citations

Role of the Parasite-Derived Prostaglandin D2 in the Inhibition of Epidermal Langerhans Cell Migration during Schistosomiasis Infection

2001 • 273 citations

IL-12 production by central nervous system microglia is inhibited by astrocytes.

1997 • 263 citations

Peroxisome proliferator-activated receptor γ activators affect the maturation of human monocyte-derived dendritic cells

2001 • 231 citations

The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues.

1989 • 221 citations

Cutting Edge: Differential Production of Prostaglandin D2 by Human Helper T Cell Subsets

2000 • 202 citations

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions

1995 • 177 citations

Peroxisome proliferator‐activated receptor γ activators inhibit interleukin‐12 production in murine dendritic cells

2000 • 166 citations

Cyclooxygenase-2-derived prostaglandin D₂is an early anti-inflammatory signal in experimental colitis

2000 • 163 citations

Differential Regulation of Raf-1 and B-Raf and Ras-Dependent Activation of Mitogen-Activated Protein Kinase by Cyclic AMP in PC12 Cells

1995 • 146 citations

Mechanisms of Persistent NF-κB Activity in the Bronchi of an Animal Model of Asthma

2000 • 127 citations

15-Deoxy-Δ12,1412,14-prostaglandins D2 and J2 Are Potent Activators of Human Eosinophils

2002 • 112 citations

Cyclic AMP Regulation of Neutrophil Apoptosis Occurs via a Novel Protein Kinase A-independent Signaling Pathway

2001 • 104 citations

Characterization of the recombinant human prostanoid DP receptor and identification of L‐644,698, a novel selective DP agonist

1998 • 80 citations

Adenosine 3′,5′-Cyclic Monophosphate (cAMP)-Dependent Inhibition of IL-5 from Human T Lymphocytes Is Not Mediated by the cAMP-Dependent Protein Kinase A

2001 • 75 citations

Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandins

2000 • 73 citations

Calcium signaling inhibits interleukin-12 production and activates CD83+ dendritic cells that induce Th2 cell development

2001 • 72 citations

15-Deoxy-Δ12,14-prostaglandin J2 Inhibits IL-10 and IL-12 Production by Macrophages

2001 • 56 citations

Role of cyclopentenone prostaglandins in rat carrageenin pleurisy

2001 • 49 citations

Cyclic AMP Inhibits PDGF-stimulated Mitogen-activated Protein Kinase Activity in Rat Aortic Smooth Muscle Cells via Inactivation of c-Raf-1 Kinase and Induction of MAP Kinase Phosphatase-1

1997 • 28 citations

Tyrosine Kinase and Phosphatidylinositol 3-Kinase Activation Are Required for Cyclic Adenosine 3′,5′-Monophosphate-Dependent Potentiation of Deoxyribonucleic Acid Synthesis Induced by Insulin-Like Growth Factor-I in FRTL-5 Cells

2000 • 27 citations

Tyrosine Kinase and Phosphatidylinositol 3-Kinase Activation Are Required for Cyclic Adenosine 3',5'-Monophosphate-Dependent Potentiation of Deoxyribonucleic Acid Synthesis Induced by Insulin-Like Growth Factor-I in FRTL-5 Cells

2000 • 6 citations