Evidence for Elevated Levels of Histamine, Prostaglandin D₂, and Other Bronchoconstricting Prostaglandins in the Airways of Subjects with Mild Asthma

Standardization of bronchial inhalation challenge procedures

1975 • 1,489 citations

Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution

1986 • 1,093 citations

Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection.

1976 • 999 citations

Eosinophils and Mast Cells in Bronchoalveolar Lavage in Subjects with Mild Asthma: Relationship to Bronchial Hyperreactivity

1988 • 905 citations

Allergen‐induced increase in non‐allergic bronchial reactivity

1977 • 883 citations

Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance

1981 • 764 citations

Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma

1988 • 635 citations

Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.

1982 • 588 citations

Bronchoalveolar Cell Profiles of Asthmatic and Nonasthmatic Subjects

1987 • 480 citations

EFFECTS OF INHALED PLATELET ACTIVATING FACTOR ON PULMONARY FUNCTION AND BRONCHIAL RESPONSIVENESS IN MAN

1986 • 478 citations

Release of Prostaglandin D₂into Human Airways during Acute Antigen Challenge

1986 • 476 citations

Activation of Pulmonary Mast Cells by Bronchoalveolar Allergen Challenge:In VivoRelease of Histamine and Tryptase in Atopic Subjects with and without Asthma

1988 • 352 citations

The Bronchoconstrictor Effect of Inhaled Prostaglandin D2 in Normal and Asthmatic Men

1984 • 319 citations

Bronchial hyperirritability in healthy subjects after exposure to ozone.

1978 • 260 citations

Bradykinin-induced bronchoconstriction in humans. Mode of action.

1987 • 260 citations

Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction.

1985 • 254 citations

Peripheral Lung Resistance in Normal and Asthmatic Subjects

1990 • 246 citations

Arachidonic acid metabolism in purified human lung mast cells.

1984 • 234 citations

Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness.

1987 • 221 citations

Cyclooxygenase Metabolism of Endogenous Arachidonic Acid by Cultured Human Tracheal Epithelial Cells

1989 • 202 citations

A sensitive and specific enzymatic isotopic assay for tissue histamine.

1966 • 200 citations

Limitations of Using Urea to Quantify Epithelial Lining Fluid Recovered by Bronchoalveolar Lavage^1–3

1987 • 191 citations

Mast cells in bronchoalveolar lumen of patients with bronchial asthma.

1984 • 188 citations

The effects of inhaled leukotriene E4 on the airway responsiveness to histamine in subjects with asthma and normal subjects

1988 • 176 citations

Anaphylactic release of thromboxane A2, prostaglandin D2, and prostacyclin from human lung parenchyma.

1981 • 168 citations

Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans.

1985 • 136 citations

Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects.

1986 • 135 citations

Synthesis of leukotriene B4, and prostanoids by human alveolar macrophages: analysis by gas chromatography/ mass spectrometry

1984 • 130 citations

Inflammation and asthma

1984 • 123 citations

A novel double-isotope technique for the enzymatic assay of plasma histamine: application to estimation of mast cell activation assessed by antigen challenge in asthmatics

1982 • 119 citations

Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine.

1986 • 110 citations

Human lung macrophage-derived histamine-releasing activity is due to IgE-dependent factors.

1986 • 107 citations

Neuropeptides in the lung: Localization, function, and pathophysiologic implications*1

1987 • 103 citations

Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer.

1985 • 101 citations

9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways.

1987 • 97 citations

Rat histamine N-methyltransferase. Quantification, tissue distribution, purification, and immunologic properties.

1983 • 88 citations

Mediator Release in an Isolated Airway Segment in Subjects with Asthma

1988 • 87 citations

Fluid Dynamics during Bronchoalveolar Lavage

1988 • 79 citations

Mechanism of Platelet Activating Factor-induced Bronchoconstriction in Humans

1988 • 77 citations

Mast cell and histamine content of human bronchoalveolar lavage fluid.

1985 • 66 citations

Histamine levels in bronchoalveolar lavage from patients with asthma, sarcoidosis, and idiopathic pulmonary fibrosis*1

1987 • 57 citations

Cholinergic neuromodulation by prostaglandin D2 in canine airway smooth muscle

1987 • 51 citations

Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis

1985 • 49 citations

Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils. A potential mast cell-eosinophil interaction.

1988 • 47 citations

Airway hyperresponsiveness and inflammation

1987 • 46 citations

Summary and recommendations of a workshop on the investigative use of fiberoptic bronchoscopy and bronchoalveolar lavage in individuals with asthma*1, *2, *3, *4

1985 • 37 citations

Profiling of bisenoic prostaglandins and thromboxane B2 in bronchoalveolar fluid from the lower respiratory tract of human subjects by combined capillary gas chromatography-mass spectrometry

1988 • 35 citations

The influence of pretreatment with prostaglandin F2α on bronchial sensitivity to inhaled histamine and methacholine in normal subjects

1984 • 24 citations