Thymocyte Sensitivity and Supramolecular Activation Cluster Formation Are Developmentally Regulated: A Partial Role for Sialylation

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Glycosylation and the Immune System

2001 • 1,515 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

The Immunological Synapse

2001 • 987 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

2001 • 852 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Separation of mouse thymocytes into two subpopulations by the use of peanut agglutinin

1976 • 513 citations

The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

1994 • 457 citations

The role of lipid rafts in T cell antigen receptor (TCR) signalling

2000 • 453 citations

Staging and resetting T cell activation in SMACs

2002 • 343 citations

TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts

2002 • 330 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis

2000 • 301 citations

Immunochemical studies on the specificity of the peanut (Arachis hypogaea) Agglutinin

1976 • 286 citations

Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy

2002 • 278 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

The role of lipid rafts in signalling and membrane trafficking in T lymphocytes

2001 • 252 citations

The Impact of Duration versus Extent of TCR Occupancy on T Cell Activation

2001 • 235 citations

Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells

1998 • 208 citations

Developmentally Regulated Glycosylation of the CD8αβ Coreceptor Stalk Modulates Ligand Binding

2001 • 200 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

2000 • 194 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation

2001 • 187 citations

Divergent Changes in the Sensitivity of Maturing T Cells to Structurally Related Ligands Underlies Formation of a Useful T Cell Repertoire

1999 • 176 citations

Sensory Adaptation in Naive Peripheral CD4 T Cells

2001 • 163 citations

Imaging Synapse Formation during Thymocyte Selection

2002 • 142 citations

Information transfer at the immunological synapse

2000 • 141 citations

Immature CD4+CD8+ Thymocytes Form a Multifocal Immunological Synapse with Sustained Tyrosine Phosphorylation

2002 • 138 citations

Internalization and Intracellular Fate of TCR-CD3 Complexes

2000 • 133 citations

Formation of supramolecular activation clusters on freshex vivoCD8⁺T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells

2001 • 131 citations

Autoreactivity, dynamic tuning and selectivity

2001 • 130 citations

Characterization of the activation-associated isoform of CD43 on murine T lymphocytes.

1994 • 129 citations

Cd2 Sets Quantitative Thresholds in T Cell Activation

1999 • 129 citations

Integrins in the Immune System

1999 • 122 citations

Dynamic Tuning of T Cell Reactivity by Self-Peptide–Major Histocompatibility Complex Ligands

2001 • 114 citations

Lipid rafts and T cell receptor signaling: a critical re-evaluation

2002 • 106 citations

TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1.

1999 • 85 citations

Binding of protein kinase B to the plakin family member periplakin

2002 • 82 citations

TCR Signaling Thresholds Regulating T Cell Development and Activation Are Dependent upon SHP-1

1999 • 76 citations

Sialic Acid Capping of CD8β Core 1-O-Glycans Controls Thymocyte-Major Histocompatibility Complex Class I Interaction

2003 • 75 citations

Soluble peptide–MHC monomers cause activation of CD8⁺T cells through transfer of the peptide to T cell MHC molecules

2002 • 71 citations

Cell surface sialic acid influences tumor cell recognition in the mixed lymphocyte reaction.

1987 • 67 citations

Antigen‐presenting Cells for CD8+ T Cells

1990 • 60 citations

Degree of ERK activation influences both positive and negative thymocyte selection

2000 • 59 citations

Differential binding of fluorescein-labeled lectins to mouse thymocytes: subsets revealed by flow microfluorometry.

1980 • 58 citations

Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-K^bmolecules

2002 • 56 citations

Human CD8⁺T cells do not require the polarization of lipid rafts for activation and proliferation

2002 • 56 citations

Immature CD4+CD8+ Thymocytes Do Not Polarize Lipid Rafts in Response to TCR-Mediated Signals

2000 • 56 citations

Cutting Edge: TCR Engagement and Triggering in the Absence of Large-Scale Molecular Segregation at the T Cell-APC Contact Site

2002 • 55 citations

T cell activation results in physical modification of the mouse CD8 beta chain.

1994 • 52 citations

Opening a Window on Thymic Positive Selection: Developmental Changes in the Influence of Cosignaling by Integrins and CD28 on Selection Events Induced by TCR Engagement

2000 • 43 citations

Regulation of integrin function by T cell activation

1999 • 25 citations

TCR Reserve: A Novel Principle of CD4 T Cell Activation by Weak Ligands

2003 • 23 citations

Assays of Thymic Selection: Fetal Thymus Organ Culture and In Vitro Thymocyte Dulling Assay

2003 • 20 citations

Positive Selection Is Limited by Available Peptide-Dependent MHC Conformations

2000 • 16 citations

Viral Neuraminidase Treatment of Dendritic Cells Enhances Antigen-Specific CD8+ T Cell Proliferation, but Does Not Account for the CD4+ T Cell Independence of the CD8+ T Cell Response during Influenza Virus Infection

2001 • 16 citations

Developmental regulation of TCR efficiency

2000 • 7 citations