TOR Complex 1 Includes a Novel Component, Tco89p (YPL180w), and Cooperates with Ssd1p to Maintain Cellular Integrity in Saccharomyces cerevisiae

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

1998 • 5,253 citations

Global analysis of protein localization in budding yeast

2003 • 4,276 citations

Global analysis of protein expression in yeast

2003 • 3,790 citations

A comprehensive two-hybrid analysis to explore the yeast protein interactome

2001 • 3,564 citations

Designer deletion strains derived fromSaccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications

1998 • 3,373 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

2002 • 2,782 citations

[1] Getting started with yeast

1991 • 2,456 citations

Direct analysis of protein complexes using mass spectrometry

1999 • 2,242 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

2002 • 1,831 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

2003 • 927 citations

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

1999 • 918 citations

Overview of manual and automated DNA sequencing by the dideoxy chain termination method

1991 • 840 citations

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993 • 832 citations

Polarization of cell growth in yeast II. The role of the cortical actin cytoskeleton

2000 • 603 citations

The target of rapamycin (TOR) proteins

2001 • 595 citations

The TOR signaling cascade regulates gene expression in response to nutrients

1999 • 593 citations

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

1999 • 526 citations

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases.

1996 • 499 citations

The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.

1995 • 498 citations

Regulation of Ribosome Biogenesis by the Rapamycin-sensitive TOR-signaling Pathway inSaccharomyces cerevisiae

1999 • 378 citations

Planning for smallpox outbreaks

2003 • 373 citations

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

2002 • 357 citations

The SIT4 protein phosphatase functions in late G1 for progression into S phase.

1991 • 340 citations

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

1999 • 339 citations

The protein kinase C‐mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae

1999 • 325 citations

The Yeast Phosphatidylinositol Kinase Homolog TOR2 Activates RHO1 and RHO2 via the Exchange Factor ROM2

1997 • 304 citations

[2] Micromanipulation and dissection of asci

1991 • 303 citations

Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant.

1996 • 280 citations

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

1999 • 276 citations

Cell wall perturbation in yeast results in dual phosphorylation of the Slt2/Mpk1 MAP kinase and in an Slt2-mediated increase in FKS2–lacZ expression, glucanase resistance and thermotolerance

2000 • 273 citations

TOR2 is required for organization of the actin cytoskeleton in yeast

1996 • 261 citations

Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins

2000 • 236 citations

TIP41 Interacts with TAP42 and Negatively Regulates the TOR Signaling Pathway

2001 • 235 citations

Synthetic enhancement in gene interaction: a genetic tool come of age

1993 • 234 citations

Tor Kinases Are in Distinct Membrane-associated Protein Complexes inSaccharomyces cerevisiae

2003 • 233 citations

The identification of a second cell cycle control on the HO promoter in yeast: Cell cycle regulation of SWI5 nuclear entry

1990 • 215 citations

TOR2 Is Part of Two Related Signaling Pathways Coordinating Cell Growth in Saccharomyces cerevisiae

1998 • 173 citations

The Septins Are Required for the Mitosis-specific Activation of the Gin4 Kinase

1998 • 160 citations

The Tor Pathway Regulates Gene Expression by Linking Nutrient Sensing to Histone Acetylation

2003 • 156 citations

Multiple Roles of Tap42 in Mediating Rapamycin-Induced Transcriptional Changes in Yeast

2003 • 156 citations

Regulation of the Cell Integrity Pathway by Rapamycin-sensitive TOR Function in Budding Yeast

2002 • 147 citations

Yeast Protein Kinases and the RHO1 Exchange Factor TUS1 Are Novel Components of the Cell Integrity Pathway in Yeast

2002 • 143 citations

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

2003 • 140 citations

Saccharomyces cerevisiae MPT5 and SSD1 Function in Parallel Pathways to Promote Cell Wall Integrity

2002 • 127 citations

Ssd1p of Saccharomyces cerevisiae Associates with RNA

1997 • 109 citations

GUP1 and its close homologue GUP2, encoding multimembrane‐spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae

2000 • 100 citations

Mutations in the Saccharomyces cerevisiae Type 2A Protein Phosphatase Catalytic Subunit Reveal Roles in Cell Wall Integrity, Actin Cytoskeleton Organization and Mitosis

1997 • 96 citations

Calcofluor Antifungal Action Depends on Chitin and a Functional High-Osmolarity Glycerol Response (HOG) Pathway: Evidence for a Physiological Role of the Saccharomyces cerevisiae HOG Pathway under Noninducing Conditions

2000 • 91 citations

Protein Kinase Activity and Identification of a Toxic Effector Domain of the Target of Rapamycin TOR Proteins in Yeast

1999 • 81 citations

The Protein Kinase C Pathway Is Required for Viability in Quiescence in Saccharomyces cerevisiae

2002 • 78 citations

Sit4 Is Required for Proper Modulation of the Biological Functions Mediated by Pkc1 and the Cell Integrity Pathway inSaccharomyces cerevisiae

2002 • 69 citations

Regulation of yeast protein kinase C activity by interaction with the small GTPase Rho1p through its amino-terminal HR1 domain

2002 • 50 citations

Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast.

1996 • 43 citations