Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

The kit Ligand, Stem Cell Factor

1993 • 653 citations

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

1991 • 606 citations

Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells

1993 • 546 citations

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

1994 • 459 citations

Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages.

1991 • 454 citations

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

1994 • 453 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 365 citations

Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells

1993 • 345 citations

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor

1991 • 341 citations

Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1 beta (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin

1993 • 334 citations

Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells

1994 • 319 citations

Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family.

1991 • 300 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 291 citations

Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures

1993 • 280 citations

Role of c-kit ligand in the expansion of human hematopoietic progenitor cells

1992 • 218 citations

The Biology of CSF-1 and Its Receptor

1992 • 216 citations

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells

1991 • 202 citations

Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow

1991 • 195 citations

Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential

1993 • 166 citations

Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells

1994 • 153 citations

Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interleukin 3 fusion protein.

1991 • 140 citations

Maintenance of transplantation potential in ex vivo expanded CD34(+)- selected human peripheral blood progenitor cells

1994 • 139 citations

Human burst-forming units-erythroid need direct interaction with stem cell factor for further development

1991 • 138 citations

Long-term generation and expansion of human primitive hematopoietic progenitor cells in vitro

1993 • 135 citations

Detection of a human CFC with a high proliferative potential

1989 • 135 citations

Cytokine-induced selective expansion and maturation of erythroid versus myeloid progenitors from purified cord blood precursor cells

1993 • 110 citations

In vitro expansion of human peripheral blood CD34+ cells

1993 • 105 citations

Interleukin-11 stimulates the proliferation of human hematopoietic CD34+ and CD34+CD33-DR- cells and synergizes with stem cell factor, interleukin-3, and granulocyte-macrophage colony-stimulating factor.

1993 • 61 citations

The in vitro and in vivo effects of stem cell factor on human hematopoiesis

1996 • 54 citations

The selective enhancing influence of hemin and products of human erythrocytes on colony formation by human multipotential (CFUGEMM) and erythroid (BFUE) progenitor cells in vitro.

1983 • 53 citations

Regulation of interleukin 4 receptors on human T cells

1990 • 42 citations

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor

1991 • 36 citations

Expansion of cord blood progenitors and use for hemopoietic reconstitution

1996 • 29 citations

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells

1991 • 22 citations

Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures

1993 • 20 citations

Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells

1994 • 16 citations

c‐kitligand combined with GM‐CSF and/or IL‐3 can expand CD34⁺hematopoietic progenitor subsets for several weeks in vitro

1994 • 16 citations

Maintenance of transplantation potential in ex vivo expanded CD34(+)- selected human peripheral blood progenitor cells

1994 • 15 citations

Effects of mast cell growth factor, interleukin-3, and interleukin-6 on human primitive hematopoietic progenitors from bone marrow and cord blood.

1993 • 14 citations

Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow

1991 • 14 citations

Transitional changes in immunophenotypic subpopulations of human peripheral blood CD34+ cells expanded in vitro.

1994 • 13 citations

Role of c-kit ligand in the expansion of human hematopoietic progenitor cells

1992 • 12 citations

Cytokine-induced selective expansion and maturation of erythroid versus myeloid progenitors from purified cord blood precursor cells

1993 • 10 citations

Long-term generation and expansion of human primitive hematopoietic progenitor cells in vitro

1993 • 10 citations

Detection of a human CFC with a high proliferative potential

1989 • 9 citations

In vitro expansion of human peripheral blood CD34+ cells

1993 • 6 citations