The molecular biology of immunoglobulin D

A catalogue of splice junction sequences

1982 • 3,861 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Variety in the level of gene control in eukaryotic cells

1982 • 772 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends

1980 • 562 citations

Induction of T and B cell immunity by anti‐idiotypic antibody

1975 • 448 citations

A NEW CLASS OF HUMAN IMMUNOGLOBULINS

1965 • 393 citations

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

1982 • 323 citations

Immunoglobulin-Receptors Revisited

1975 • 302 citations

Frequency of B lymphocytes responsive to anti-immunoglobulin.

1982 • 302 citations

The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes

1981 • 260 citations

Tissue-specific expression of mouse α-amylase genes: Nucleotide sequence of isoenzyme mRNAs from pancreas and salivary gland

1980 • 259 citations

Sequence at the 3′ end of globin mRNA shows homology with immunoglobulin light chain mRNA

1974 • 256 citations

Specific Suppression of the Antibody Response by Antibodies to Receptors

1972 • 254 citations

Cloning and complete nucleotide sequence of mouse immunoglobulin γ1 chain gene

1979 • 230 citations

Transcription and RNA processing by the DNA tumour viruses

1980 • 228 citations

Multiple Immunoglobulin Heavy-Chain Gene Transcripts in Abelson Murine Leukemia Virus-Transformed Lymphoid Cell Lines

1982 • 228 citations

Human immunoglobulin heavy chain genes: evolutionary comparisons of Cμ, Cδ and Cγ genes and associated switch sequences

1981 • 205 citations

Cell surface immunoglobulin. XI. The appearance of an IgD-like molecule on murine lymphoid cells during ontogeny.

1975 • 200 citations

Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D

1980 • 188 citations

Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences

1981 • 173 citations

Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.

1980 • 170 citations

Induction and Suppression of Polyclonal Antibody Responses by Anti‐Ig Reagents and Antigen‐Nonspecific Helper Factors:

1980 • 169 citations

Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

1983 • 165 citations

Structure of genes for membrane and secreted murine IgD heavy chains

1982 • 158 citations

Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.

1982 • 157 citations

Memory B cells at successive stages of differentiation. Affinity maturation and the role of IgD receptors

1980 • 156 citations

Globin RNA transcription: A possible termination site and demonstration of transcriptional control correlated with altered chromatin structure

1982 • 144 citations

Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms

1981 • 143 citations

Expression of lymphocyte surface IgE does not require switch recombination

1982 • 133 citations

Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice.

1977 • 129 citations

B Lymphocyte: Activation by Insoluble Anti-Immunoglobulin: Induction of Immunoglobulin Secretion by a T Cell-Dependent Soluble Factor

1979 • 128 citations

The Class of Surface Immunoglobulin on Virgin and Memory B Lymphocytes

1977 • 128 citations

Communications. IgD-bearing human lymphocytes.

1972 • 124 citations

Mouse Immunoglobulin D: Messenger RNA and Genomic DNA Sequences

1980 • 123 citations

Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes.

1975 • 120 citations

Sequence of the Cloned Gene for the Constant Region of Murine γ2b Immunoglobulin Heavy Chain

1979 • 117 citations

Control of Idiotope Expression by Monoclonal Anti-Idiotope Antibodies

1980 • 112 citations

Effects of Anti‐Ig Antibodies on the Development and Differentiation of B Cells

1980 • 110 citations

Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells.

1976 • 108 citations

The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence.

1982 • 108 citations

Complete nucleotide sequence of mouse imunoglobulin μ gene and comparison with other immunoglobulin heavy chain genes

1980 • 108 citations

Unusual sequences in the murine immunoglobulin μ–δ heavy-chain region

1983 • 108 citations

Activation of mouse lymphocytes by anti-immunoglobulin. II. A thymus-independent response by a mature subset of B lymphocytes.

1978 • 100 citations

Mouse IgA heavy chain gene sequence: implications for evolution of immunoglobulin hinge axons.

1981 • 99 citations

Gene segments encoding transmembrane carboxyl termini of immunoglobulin γ chains

1981 • 99 citations

Expression of IgD by murine lymphocytes. Loss of surface IgD indicates maturation of memory B cells.

1978 • 98 citations

IgD-Bearing Human Lymphocytes

1972 • 97 citations

Role of IgD in the immune response and tolerance. I. Anti-delta pretreatment facilitates tolerance induction in adult B cells in vitro.

1977 • 93 citations

Surface immunoglobulins of lipopolysaccharide‐stimulated spleen cells The behaviour of IgM, IgD and IgG

1977 • 92 citations

IgD-secreting murine plasmacytomas: identification and partial characterization of two IgD myeloma proteins.

1981 • 89 citations

A model for the molecular requirements of immunoglobulin heavy chain class switching

1982 • 85 citations

Transcriptional regulation of immunoglobulin V genes

1981 • 81 citations

Simultaneous expression of immunoglobulin mu and delta heavy chains by a cloned B-cell lymphoma: a single copy of the VH gene is shared by two adjacent CH genes.

1982 • 79 citations

Strategies of Immune Regulation

1980 • 73 citations

Cloning of mouse immunoglobulin epsilon gene and its location within the heavy chain gene cluster.

1981 • 70 citations

Studies of Generation of B-cell Diversity in Mouse, Man, and Chicken

1977 • 70 citations

Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.

1981 • 69 citations

Genetics, Cellular Expression and Function of IgD and IgM Receptors

1977 • 69 citations

mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain.

1982 • 68 citations

Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains.

1982 • 67 citations

The complete nucleotide sequence of mouse immunoglobulin γ2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer

1981 • 66 citations

The role of surface IgD in the response to thymic-independent antigens.

1977 • 66 citations

The murine immunoglobulin alpha gene expresses multiple transcripts from a unique membrane exon.

1983 • 65 citations

Characterization of a spontaneous murine B cell leukemia (BCL1). I. Cell surface expression of IgM, IgD, Ia, and FcR.

1979 • 64 citations

Immunoglobulin class switching: Developmentally regulated DNA rearrangements during differentiation

1980 • 62 citations

Complete amino acid sequence of the delta heavy chain of human immunoglobulin D.

1982 • 60 citations

Mouse immunoglobulin D: construction and characterization of a cloned delta chain cDNA.

1980 • 58 citations

Spontaneous Immunoglobulin Class Switching in Myeloma and Hybridoma Cell Lines Differs from Physiological Class Switching

1982 • 53 citations

The end of the message

1982 • 52 citations

Immunoglobulin heavy chain genes: demethylation accompanies class switching.

1981 • 52 citations

Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.

1978 • 52 citations

Characterization of a B Cell Defect in the NZB Mouse Manifested by an Increased Ratio of Surface IgM to IgD

1978 • 50 citations

Characterization of a spontaneous murine B cell leukemia (BCL1). II. Tumor cell proliferation and IgM secretion after stimulation by LPS.

1979 • 50 citations

Physiology of IgD. I. Compensatory phenomena in B lymphocyte activation in mice treated with anti-IgD antibodies.

1981 • 50 citations

Immunoglobulin heavy-chain constant-region genes

1982 • 49 citations

Adenovirus gene expression: Control at multiple steps of mRNA biogenesis

1982 • 43 citations

The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. IV. Role of IgD-bearing cells in the propagation of immunologic memory.

1979 • 42 citations

Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy chain locus.

1982 • 39 citations

The Activation of Murine B Cells: The Role of Surface Immunoglobulins

1980 • 39 citations

Demonstration of Mouse Serum IgD

1979 • 39 citations

Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function.

1981 • 37 citations

Induction of proliferation and differentiation of neoplastic B cells by anti-immunoglobulin and T-cell factors.

1981 • 36 citations

The murine B cell response to TNP-polyacrylamide beads: the relationship between the epitope density of the antigen and the requirements for T cell help and surface IgD.

1980 • 34 citations

The anti‐delta suppressed mouse

1978 • 33 citations

Immunoglobulin turnover in B lymphocyte subpopulations

1975 • 33 citations

Presence of serum IgD and IgD‐containing plasma cells in the mouse

1979 • 32 citations

Immunoglobulins M and D as antigen‐binding receptors on the same cell, with shared specificity

1976 • 30 citations

Characterization of a Spontaneous Murine B Cell Leukemia (BCL1)

1979 • 30 citations

Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD.

1981 • 29 citations

Complete amino acid sequence of the Fc region of a human delta chain.

1981 • 28 citations

Characterization of a Spontaneous Murine B Cell Leukemia (BCL1)

1979 • 28 citations

Correlations between Three-dimensional Structure and Function of Immunoglobulins

1978 • 27 citations

The Relationship Between Surface Immunoglobulin Isotype and Immune Function of Murine B Lymphocytes

1979 • 26 citations

Cell surface immunoglobulin. XV. The presence of IgM and an IgD-like molecule on the same cell in murine lymphoid tissue

1976 • 25 citations

Mouse spleen and IgD-secreting plasmacytomas contain multiple IgD δ chain RNAs

1982 • 25 citations

The ontogeny of B lymphocytes V. Lipopolysaccharide‐induced changes of IgD expression on murine B lymphocytes

1979 • 22 citations

C-terminal sequence of the secreted form of mouse IgD heavy chain

1981 • 19 citations

Rat immunoglobulin delta heavy chain gene: nucleotide sequence derived from cloned cDNA

1982 • 18 citations

IDIOTYPIC CONTROL: THE EXPRESSION OF IDIOTYPES AND ITS REGULATION

1980 • 16 citations

Murine cell surface immunoglobulin: two forms of delta-heavy chain.

1979 • 14 citations

Simultaneous expression of mouse immunoglobulins M and D is determined by the same homolog of chromosome 12.

1980 • 13 citations

IgD Is Present on the Cell Surface of Murine Lymphocytes in Two Forms: δ2L2 and δL

1979 • 12 citations

Murine Cell Surface Immunoglobulin: Two Forms of δ-Heavy Chain

1979 • 6 citations

DEVELOPMENTAL ASPECTS OF RAT IgD EXPRESSION AND THE CONSEQUENCES OF IgD MODULATION*

1982 • 5 citations

Obituary: E. R. Creed

1979 • 2 citations

Correlations between Three-Dimensional Structure and Function of Immunoglobulins

1978 • 1 citations