Complete structure and organization of immunoglobulin heavy chain constant region genes in a phylogenetically primitive vertebrate.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

DNA cloning : a practical approach

1985 • 2,302 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends

1980 • 562 citations

Role of the Conserved AAUAAA Sequence: Four AAUAAA Point Mutants Prevent Messenger RNA 3′ End Formation

1984 • 561 citations

PHYLOGENY OF IMMUNOGLOBULIN STRUCTURE AND FUNCTION

1967 • 404 citations

Immunoglobulin Genes

1983 • 341 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

1982 • 323 citations

5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains

1980 • 238 citations

Structure of human immunoglobulin gamma genes: implications for evolution of a gene family

1982 • 231 citations

Major reorganization of immunoglobulin VH segmental elements during vertebrate evolution

1986 • 223 citations

Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D

1980 • 188 citations

Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.

1987 • 187 citations

Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences

1981 • 173 citations

Immunoglobulin messenger RNAs in murine cell lines that have characteristics of immature B lymphocytes

1979 • 158 citations

Amino acid sequence of a mouse immunoglobulin mu chain.

1979 • 134 citations

Regulation of membrane IgM expression in secretory B cells: translational and post-translational events.

1987 • 125 citations

Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development.

1987 • 110 citations

Regulated production of mu m and mu s mRNA requires linkage of the poly(A) addition sites and is dependent on the length of the mu s-mu m intron.

1986 • 109 citations

Immunoglobulin VH gene structure and diversity in Heterodontus, a phylogenetically primitive shark.

1985 • 98 citations

Nucleotide sequence of the constant region of a chicken μ heavy chain immonoglobulin mRNA

1983 • 85 citations

Amino acid sequence of heavy chain from Xenopus laevis IgM deduced from cDNA sequence: implications for evolution of immunoglobulin domains.

1988 • 84 citations

Extensive families of constant region genes in a phylogenetically primitive vertebrate indicate an additional level of immunoglobulin complexity.

1987 • 55 citations

Sequence of the gene for the constant region of the μ chain of Balb/c mouse immunoglobulin

1981 • 47 citations

Effects of intron length on differential processing of mouse mu heavy-chain mRNA.

1987 • 40 citations

Protein-binding site at the immunoglobulin mu membrane polyadenylylation signal: possible role in transcription termination.

1987 • 38 citations

Immunoglobulin RNA Rearrangements in B Lymphocyte Differentiation

1984 • 33 citations

Phylogenetic conservation of immimoglobulin heavy chains: direct comparison of hamster and mouse Cμ genes

1985 • 30 citations

A comparative study of J chain: Structure and stoichiometry in human and nurse shark IgM

1976 • 25 citations

Nuclear Factors in B Lymphoma Enhance Splicing of Mouse Membrane-Bound μ mRNA inXenopusOocytes

1988 • 18 citations

Effects of Intron Length on Differential Processing of Mouse μ Heavy-Chain mRNA

1987 • 15 citations

Immunoglobulin switch region-like sequences inDrosophila melanogaster

1982 • 14 citations