The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated.

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

Genetic and physical linkage of exogenous sequences in transformed cells

1980 • 486 citations

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

1987 • 247 citations

Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene.

1987 • 241 citations

Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line

1982 • 173 citations

Differentiation-dependent chromatin alterations precede and accompany transcription of immunoglobulin light chain genes.

1984 • 167 citations

Muscle-specific activation of a methylated chimeric actin gene

1986 • 135 citations

Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.

1984 • 135 citations

Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variant.

1984 • 127 citations

Two kappa immunoglobulin genes are expressed in the myeloma S107

1981 • 117 citations

High expression of cloned immunoglobulin k gene in transgenic mice is restricted to B lymphocytes

1984 • 114 citations

Functional significance and evolutionary development of the 5′-terminal regions of immunoglobulin variable-region genes

1982 • 105 citations

Methylation status and DNase I sensitivity of immunoglobulin genes: changes associated with rearrangement.

1983 • 102 citations

Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.

1983 • 101 citations

Regulated expression of an immunoglobulin kappa gene introduced into a mouse lymphoid cell line.

1982 • 100 citations

Transcriptional and posttranscriptional control of immunoglobulin mRNA production during Blymphocyte development

1986 • 99 citations

Mechanisms that Regulate Immunoglobulin Gene Expression

1985 • 97 citations

Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression.

1985 • 92 citations

Selective suppression of the transcription of ribosomal genes in mouse‐human hybrid cells

1979 • 91 citations

Transcriptional regulation of immunoglobulin V genes

1981 • 81 citations

Inducible transcription of the unrearranged kappa constant region locus is a common feature of pre-B cells and does not require DNA or protein synthesis.

1985 • 79 citations

Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independent of methylatlon status

1984 • 65 citations

Nonproductive kappa immunoglobulin genes: recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation.

1985 • 63 citations

SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation

1986 • 56 citations

Properties of a mouse ribosomal protein promoter.

1986 • 51 citations

Tandem kappa immunoglobulin promoters are equally active in the presence of the kappa enhancer: Implications for models of enhancer function

1986 • 47 citations

Site-Specific Demethylation and Normal Chromatin Structure of the Human Dihydrofolate Reductase Gene Promoter after Transfection into CHO Cells

1987 • 32 citations

Pre-B cells in κ-transgenic mice

1985 • 31 citations

Nonproductive Kappa Immunoglobulin Genes: Recombinational Abnormalities and Other Lesions Affecting Transcription, RNA Processing, Turnover, and Translation

1985 • 29 citations

Specific 5' and 3' regions of the mu-chain gene are undermethylated at distinct stages of B-cell differentiation.

1985 • 27 citations

Activation of immunoglobulin mu gene expression involves stepwise demethylation.

1984 • 24 citations

Site-specific demethylation and normal chromatin structure of the human dihydrofolate reductase gene promoter after transfection into CHO cells.

1987 • 13 citations

Mechanisms that Regulate Immunoglobulin Gene Expression

1985 • 10 citations