Purification and Activation of the Double-Stranded RNA-Dependent eIF-2 Kinase DAI

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels

1980 • 3,334 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis

1977 • 750 citations

Purification and properties of the replicative intermediate of the RNA bacteriophage R17.

1966 • 497 citations

Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesis

1976 • 435 citations

Interferon-induced enzymatic activities and their role in the antiviral state

1979 • 392 citations

Initiation of protein synthesis in mammalian cells

1986 • 359 citations

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

1986 • 358 citations

Interferon, double-stranded RNA, and protein phosphorylation.

1976 • 328 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

Structural requirements of double-stranded RNA for the activation of 2‘,5‘-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells.

1979 • 263 citations

A mechanism for the control of protein synthesis by adenovirus VA RNAI

1986 • 256 citations

The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates

1975 • 254 citations

Specific phosphorylation in vitro of a protein associated with ribosomes of interferon‐treated mouse L cells

1976 • 238 citations

Regulation of protein synthesis initiation in eucaryotes

1983 • 227 citations

Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase.

1978 • 194 citations

IMPACT OF VIRUS INFECTION ON HOST CELL PROTEIN SYNTHESIS

1987 • 188 citations

Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity.

1987 • 181 citations

Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNAI

1985 • 157 citations

Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection.

1985 • 155 citations

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.

1985 • 138 citations

Interferon, double-stranded RNA, and protein phosphorylation. Characteristics of a double-stranded RNA-activated protein kinase system partially purified from interferon treated Ehrlich ascites tumor cells.

1978 • 128 citations

Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis.

1985 • 117 citations

Characterization of a specific kinase inhibitory factor produced by vaccinia virus which inhibits the interferon-induced protein kinase

1984 • 114 citations

Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system

1984 • 113 citations

Interferon-mediated, double-stranded RNA-dependent protein kinase is inhibited in extracts from vaccinia virus-infected cells

1984 • 101 citations

The interferon-induced protein kinase PK-i from mouse L cells.

1979 • 81 citations

Modification of protein synthesis initiation factors and the shut-off of host protein synthesis in adenovirus-infected cells

1989 • 80 citations

Effects of mutations in stem and loop regions on the structure and function of adenovirus VA RNAI.

1988 • 78 citations

Two interferon-induced proteins are involved in the protein kinase complex dependent on double-stranded RNA

1985 • 78 citations

Mechanism of interferon action. Purification and substrate specificities of the double-stranded RNA-dependent protein kinase from untreated and interferon-treated mouse fibroblasts.

1985 • 78 citations

Detection of activated double-stranded RNA-dependent protein kinase in 3T3-F442A cells.

1988 • 74 citations

Translational control

1987 • 47 citations

The conformation of adenovirus VAI-RNA in solution

1981 • 45 citations

Regulation of protein synthesis in rabbit reticulocyte lysates: Purification and initial characterization of the double stranded RNA activated protein kinase

1980 • 44 citations

Characterization of purified double-stranded RNA-activated eIF-2 alpha kinase from rabbit reticulocytes.

1981 • 39 citations

[68] Purification of double-stranded RNA-dependent protein kinase from mouse fibroblasts

1986 • 35 citations

[37] Double-stranded RNA-dependent eIF-2α protein kinase

1983 • 33 citations

Purification and characterization of a latent precursor of a double-stranded RNA dependent protein kinase from reticulocyte lysates

1980 • 26 citations

INTERFERON‐INDUCED ENZYMES: ACTIVATION AND ROLE IN THE ANTIVIRAL STATE*

1980 • 18 citations