Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation

A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects

1968 • 11,801 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

Neuroactive steroids

1992 • 1,260 citations

Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance

1992 • 1,098 citations

Sleep deprivation: Effect on sleep stages and EEG power density in man

1981 • 1,001 citations

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

1991 • 943 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma

1984 • 891 citations

Brain corticosteroid receptor balance and homeostatic control

1991 • 858 citations

Electroporation for the efficient transfection of mammalian cells with DNA

1987 • 856 citations

Non-genomic and genomic effects of steroids on neural activity

1991 • 731 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

1987 • 601 citations

The neuronal mineralocorticoid eeceptor as a mediator of glucocorticoid response

1988 • 576 citations

Nucleotide sequence of a full-length cDNA for mousecytosketetal β-actin raRNA

1986 • 556 citations

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

1991 • 521 citations

Neurosteroids act on recombinant human GABAA receptors

1990 • 515 citations

The fast Hartley transform

1984 • 453 citations

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

1992 • 442 citations

Neurosteroids: Biosynthesis of Pregnenolone and Progesterone in Primary Cultures of Rat Glial Cells*

1989 • 372 citations

CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS¹

1942 • 348 citations

Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in brain?

1987 • 329 citations

Anxiolytic activity of an endogenous adrenal steroid

1986 • 317 citations

Effects of Corticotropin-Releasing Factor and Growth Hormone-Releasing Factor on Sleep and Activity in Rats

1986 • 313 citations

Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.

1987 • 294 citations

Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons

1988 • 271 citations

Effects of Intravenous Corticotropin-Releasing Hormone upon Sleep-Related Growth Hormone Surge and Sleep EEG in Man

1988 • 261 citations

Steroids and depression

1991 • 242 citations

Effect of benzodiazepine hypnotics on all-night sleep EEG spectra.

1985 • 235 citations

Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor.

1992 • 226 citations

Time course of EEG power density during long sleep in humans

1990 • 225 citations

Effects of Growth Hormone-Releasing Hormone and Somatostatin on Sleep EEG and Nocturnal Hormone Secretion in Male Controls

1992 • 211 citations

Steroid modulation of the GABA/benzodiazepine receptor-linked chloride lonophore

1988 • 187 citations

Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency

1989 • 184 citations

Gluco- and antimineralocorticoid effects on human sleep: a role of central corticosteroid receptors

1991 • 163 citations

Growth hormone-releasing factor enhances sleep in rats and rabbits

1988 • 157 citations

Effect of zolpidem on sleep and sleep EEG spectra in healthy young men

1991 • 151 citations

Psychiatric implications of altered limbic-hypothalamic-pituitary-adrenocortical activity

1989 • 143 citations

Sleep induction by an adrenal steroid in the rat

1987 • 142 citations

Acute Effect of a Glucocorticoid on Normal Human Sleep

1972 • 133 citations

Sleep homeostasis in suprachiasmatic nuclei-lesioned rats: effects of sleep deprivation and triazolam administration

1992 • 127 citations

Effect of zopiclone and midazolam on sleep and EEG spectra in a phase-advanced sleep schedule.

1990 • 114 citations

Effects of seganserin, a 5-HT2 antagonist, and temazepam on human sleepsstages and EEG power spectra

1989 • 111 citations

Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptor

1990 • 109 citations

Pro‐opiomelanocortin gene: A model for negative regulation of transcription by glucocorticoids

1987 • 104 citations

Corticotropin releasing factor increases proopiomelanocortin messenger RNA in mouse anterior pituitary tumor cells.

1985 • 93 citations

Sleep-electroencephalography and the secretion of cortisol and growth hormone in normal controls

1987 • 85 citations

Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam.

1992 • 80 citations

Effects of three Benzodiazepines (Nitrazepam, Flunitrazepam and Bromazepam) on Sleep of Normal Subjects, Studied with an Automatic Sleep Scoring System

1973 • 71 citations

[21] Isolation of cytoplasmic RNA: Ribonucleoside-vanadyl complexes

1987 • 66 citations

Differential effects of hydrocortisone, fluocortolone, and aldosterone on nocturnal sleep in humans

1987 • 59 citations

The Fast Hartley Transform

1985 • 52 citations

A single dose of benzodiazepine hypnotics alters the sleep EEG in the subsequent drug-free night

1983 • 50 citations

The neurosteroids pregnenolone and pregnenolone-sulfate but not progesterone, block Ca2+ currents in acutely isolated hippocampal CA1 neurons

1991 • 49 citations

Flurazepam Effects on Slow-Wave Sleep: Stage 4 Suppressed but Number of Delta Waves Constant

1977 • 48 citations

Sleep spindle and delta changes during chronic use of a short-acting and a long-acting benzodiazepine hypnotic

1983 • 42 citations

The effects of flurazepam hydrochloride on brain electrical activity during sleep

1979 • 40 citations

Functional properties of deoxycorticosterone and spironolactone: Molecular characterization and effects on sleep-endocrine activity

1993 • 31 citations

Effects of decreased adrenal corticosteroids: Changes in sleep in normal subjects and patients with adrenal cortical insufficiency

1974 • 31 citations

Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern

1992 • 31 citations

Modulation of Delta Activity by Hypnotics in Middle-Aged Subjects: Studies with a Benzodiazepine (Flurazepam) and a Cyclopyrrolone (Zopiclone)

1986 • 23 citations

Diazepam

1988 • 16 citations

Serum-free culture of AtT 20 pituitary cells: A system for neuroendocrine studies under defined conditions

1990 • 9 citations

Modulation of nocturnal sleep-eeg in humans by neuropeptides and adrenal steroids

1991 • 3 citations