Molecular biology of GABA _A receptors

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

1989 • 1,283 citations

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

1987 • 1,166 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1987 • 730 citations

Type I and Type II GABA _A -Benzodiazepine Receptors Produced in Transfected Cells

1989 • 716 citations

Structural and functional basis for GABAA receptor heterogeneity

1988 • 590 citations

Two novel GABAA receptor subunits exist in distinct neuronal subpopulations

1989 • 532 citations

Pharmacological evidence for two kinds of GABA receptors on rat hippocampal pyramidal cells studied in vitro

1982 • 527 citations

Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family.

1987 • 431 citations

Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors

1979 • 412 citations

GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs.

1989 • 404 citations

A gamma-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex.

1983 • 368 citations

Co-localization of GABAA receptors and benzodiazepine receptors in the brain shown by monoclonal antibodies

1985 • 317 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

Benzodiazepine receptor protein identified and visualized in brain tissue by a photoaffinity label.

1980 • 275 citations

Benzodiazepine receptors are coupled to a subpopulation of gamma-aminobutyric acid (GABA) receptors: evidence from a quantitative autoradiographic study.

1981 • 262 citations

Benzodiazepine/GABA receptors and chloride channels : structural and functional properties

1986 • 260 citations

A structural model of the acetylcholine receptor channel based on partition energy and helix packing calculations

1984 • 260 citations

[³H]Propyl ?-Carboline-3-Carboxylate as a Selective Radioligand for the BZ₁Benzodiazepine Receptor Subclass

1981 • 255 citations

A novel α subunit in rat brain GABAA receptors

1989 • 251 citations

GABAA receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system.

1990 • 250 citations

Transient Expression Shows Ligand Gating and Allosteric Potentiation of GABA _A Receptor Subunits

1988 • 233 citations

Multiple benzodiazepine receptor localization by light microscopic radiohistochemistry.

1981 • 224 citations

A gamma-aminobutyric acid/benzodiazepine receptor complex from bovine cerebral cortex. Improved purification with preservation of regulatory sites and their interactions.

1984 • 208 citations

Monoclonal antibodies reveal structural homogeneity of gamma-aminobutyric acid/benzodiazepine receptors in different brain areas.

1985 • 205 citations

Single Subunits of the GABA _A Receptor Form Ion Channels with Properties of the Native Receptor

1988 • 193 citations

The Molecular Neurobiology of the Acetylcholine Receptor

1986 • 186 citations

Protein kinase C and cAMP-dependent protein kinase phosphorylate the beta subunit of the purified gamma-aminobutyric acid A receptor.

1990 • 166 citations

Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain

1988 • 159 citations

Expression of functional GABA, glycine and glutamate receptors in Xenopus oocytes injected with rat brain mRNA

1984 • 134 citations

cDNA clones coding for the structural subunit of a chicken brain nicotinic acetylcholine receptor

1988 • 131 citations

Biophysical and pharmacological properties of cloned GABAA receptor subunits expressed in xenopus oocytes

1988 • 130 citations

Heterogeneity of Glycine Receptors and Their Messenger RNAs in Rat Brain and Spinal Cord

1988 • 130 citations

Phosphorylation of γ-aminobutyrate (GABA)/benzodiazepine receptors by cyclic AMP-dependent protein kinase

1989 • 111 citations

Single channel currents activated by gamma-aminobutyric acid, muscimol, and (-)-pentobarbital in cultured mouse spinal neurons

1982 • 105 citations

Cloning and expression of a novel rat GABA_A receptor

1989 • 105 citations

The GABAA/benzodiazepine receptor is a heterotetramer of homologous alpha and beta subunits.

1987 • 101 citations

The nicotinic acetylcholine receptor: Molecular architecture of a ligand-regulated ion channel

1987 • 101 citations

GABAA-receptor expressed from rat brain α- and β-subunit cDNAs displays potentiation by benzodiazepine receptor ligands

1990 • 99 citations

Sequence and expression of human GABA_A receptor α1 and β1 subunits

1989 • 97 citations

[3H]Muscimol photolabels the γ-aminobutyric acid receptor binding site on a peptide subunit distinct from that labeled with benzodiazepines

1986 • 96 citations

Physicochemical Characterization of Detergent‐Solubilized γ‐Aminobutyric Acid and Benzodiazepine Receptor Proteins from Bovine Brain

1982 • 94 citations

Synthesis of chick brain GABA receptors by frog oocytes

1982 • 89 citations

The Benzodiazepine/GABA Receptor Complex: Molecular Size in Brain Synaptic Membranes and in Solution

1982 • 83 citations

Phosphorylation of the GABA_a/Benzodiazepine Receptor α Subunit by a Receptor‐Associated Protein Kinase

1988 • 83 citations

The mRNAs encoding GABAA/Benzodiazepine receptor subunits are localized in different cell populations of the bovine cerebellum

1988 • 79 citations

Radiation inactivation of brain [35S]t-butylbicyclophosphorothionate binding sites reveals complicated molecular arrangements of the GABA/benzodiazepine receptor chloride channel complex

1985 • 76 citations

Heterogeneity of benzodiazepine receptor interactions with gamma-aminobutyric acid and barbiturate receptor sites.

1983 • 66 citations

The γ‐aminobutyric‐acid/benzodiazepine‐receptor protein from rat brain

1987 • 62 citations

Properties of [3H]flunitrazepam binding to different benzodiazepine binding proteins

1983 • 62 citations

Evidence for the existence of several different α- and β-subunits of the GABA/benzodiazepine receptor complex from rat brain

1989 • 62 citations

Regional Distribution of the GABA_A/Benzodiazepine Receptor (α Subunit) mRNA in Rat Brain

1988 • 59 citations

gamma-aminobutyric acid receptors modulate cation binding sites coupled to independent benzodiazepine, picrotoxin, and anion binding sites.

1982 • 58 citations

Identification of the α₃‐subunit in the GABA_A receptor purified from bovine brain

1989 • 53 citations

Characterization with Antibodies of the γ‐Aminobutyric Acid_A/Benzodiazepine Receptor Complex During Development of the Rat Brain

1990 • 51 citations

γ-aminobutyric acid/benzodiazepine receptor protein carries binding sites for both ligands on both two major peptide subunits

1988 • 43 citations

Isolation of a cDNA clone for the alpha subunit of the human GABA-A receptor

1988 • 31 citations

Antibodies directed against a nonapeptide sequence of the γ-aminobutyrate (GABA)/benzodiazepine receptor α-subunit. Detection of a distinct α-like subunit in pig cerebral cortex but not cerebellum

1988 • 30 citations

Comparison of the molecular structure of GABA/benzodiazepine receptors purified from rat and human cerebellum

1987 • 27 citations

Immunological Identification of Multiple α‐Like Subunits of the γ‐Aminobutyric Acid_A Receptor Complex Purified from Neonatal Rat Cortex

1989 • 25 citations

The GABA Receptor-Chloride Ion Channel Protein Complex

1988 • 15 citations

Isolation of pharmacologically distinct GABA-benzodiazepine receptors by protein chemistry and molecular cloning.

1990 • 12 citations

Deleted Work

1955 • 0 citations