Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms

Antibodies, a laboratory manual

1989 • 12,929 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators

2002 • 602 citations

Morpholino Oligos: Making Sense of Antisense?

2002 • 538 citations

A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin

1995 • 436 citations

Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes

1996 • 408 citations

Cleavage of Chordin by Xolloid Metalloprotease Suggests a Role for Proteolytic Processing in the Regulation of Spemann Organizer Activity

1997 • 398 citations

Production of a DPP Activity Gradient in the Early Drosophila Embryo through the Opposing Actions of the SOG and TLD Proteins

1997 • 350 citations

dino and mercedes, two genes regulating dorsal development in the zebrafish embryo

1996 • 325 citations

Twisted gastrulation is a conserved extracellular BMP antagonist

2001 • 302 citations

The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1

1991 • 292 citations

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling

2000 • 278 citations

Mammalian BMP-1/Tolloid-Related Metalloproteinases, Including Novel Family Member Mammalian Tolloid-Like 2, Have Differential Enzymatic Activities and Distributions of Expression Relevant to Patterning and Skeletogenesis

1999 • 264 citations

BMP-binding modules in chordin: a model for signalling regulation in the extracellular space

2000 • 244 citations

Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid

1996 • 210 citations

Differential Regulation ofchordinExpression Domains in Mutant Zebrafish

1997 • 210 citations

Twisted gastrulation can function as a BMP antagonist

2001 • 202 citations

Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling

2001 • 187 citations

Cleavage of the BMP-4 Antagonist Chordin by Zebrafish Tolloid

1997 • 187 citations

Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems

2002 • 172 citations

Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling

2001 • 153 citations

Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor.

1994 • 139 citations

The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo

1999 • 123 citations

The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart

1999 • 118 citations

Use of Bmp1/Tll1 Doubly Homozygous Null Mice and Proteomics To Identify and Validate In Vivo Substrates of Bone Morphogenetic Protein 1/Tolloid-Like Metalloproteinases

2003 • 111 citations

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of theDrosophilaembryo

2003 • 109 citations

Patterning the zebrafish axial skeleton requires early chordin function

1999 • 105 citations

Morpholino phenocopies ofthe swirl,snailhouse,somitabun,minifin,silberblick, andpipetail mutations

2001 • 105 citations

Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity

2000 • 103 citations

Loss of cerebum function ventralizes the zebrafish embryo

1997 • 81 citations

Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development

2003 • 77 citations

Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning

1995 • 76 citations

The pro-BMP activity of Twisted gastrulation is independent of BMP binding

2003 • 71 citations

BMP1-Related Metalloproteinases Promote the Development of Ventral Mesoderm in Early Xenopus Embryos

1998 • 66 citations

Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning

2004 • 66 citations

Modulation of BMP Activity in Dorsal-Ventral Pattern Formation by the Chordin and Ogon Antagonists

2002 • 56 citations

A zebrafish vasa morphant abolishes Vasa protein but does not affect the establishment of the germline

2001 • 53 citations

Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during earlyXenopusembryogenesis

2003 • 47 citations

Combinatorial signaling by Twisted Gastrulation and Decapentaplegic

1997 • 33 citations