Affinity requirements for induction of sequential phases of human B cell activation by membrane IgM-cross-linking ligands.

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Molecular determinants of immunogenicity: the immunon model of immune response.

1976 • 366 citations

Lymphocyte stimulation: a rapid multiparameter analysis.

1976 • 363 citations

Monoclonal antibodies: Purification, fragmentation and application to structural and functional studies of class I MHC antigens

1982 • 283 citations

Quantitative variation in la antigen expression plays a central role in immune regulation

1984 • 270 citations

Fc-dependent inhibition of mouse B cell activation by whole anti-mu antibodies.

1983 • 187 citations

Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation.

1988 • 156 citations

Transmembrane Signals and Intracellular “Second Messengers” in the Regulation of Quiescent B‐Lymphocyte Activation

1987 • 137 citations

The interaction of monoclonal antibodies with MHC class I antigens on mouse spleen cells. I. Analysis of the mechanism of binding.

1984 • 115 citations

B cell activation. III. B cell plasma membrane depolarization and hyper-Ia antigen expression induced by receptor immunoglobulin cross-linking are coupled.

1983 • 101 citations

The specific induction of myc protooncogene expression in normal human B cells is not a sufficient event for acquisition of competence to proliferate.

1985 • 97 citations

B cell activation. V. Differentiation signaling of B cell membrane depolarization, increased I-A expression, G0 to G1 transition, and thymidine uptake by anti-IgM and anti-IgD antibodies.

1984 • 68 citations

In vitro and in vivo B lymphocyte-activating properties of monoclonal anti-delta antibodies. I. Determinants of B lymphocyte-activating properties.

1986 • 67 citations

Model for the binding of multivalent antigen to cells

1974 • 66 citations

The binding of monoclonal antibodies to cell-surface molecules. A quantitative analysis with immunoglobulin G against two alloantigenic determinants of the human transplantation antigen HLA-A2

1983 • 56 citations

Activation and proliferation signals in mouse B cells. III. Intact (IGG) anti-immunoglobulin antibodies activate B cells but inhibit induction of DNA synthesis.

1984 • 48 citations

Analysis of the interaction of antibodies with immunoglobulin idiotypes on neoplastic B lymphocytes: implications for immunotherapy.

1987 • 47 citations

Anti-IgM-mediated B cell signaling. Molecular analysis of ligand binding requisites for human B cell clonal expansion and tolerance.

1988 • 43 citations

Abortive activation of B lymphocytes by monoclonal anti-immunoglobulin antibodies.

1986 • 40 citations

The affinity threshold for antigenic triggering differs for tolerance susceptible immature precursors vs mature primary B cells.

1986 • 39 citations

Antigen binding to receptors on immunocompetent cells

1974 • 30 citations

Endocytosis of antigen, anti-idiotype, and anti-immunoglobulin antibodies and receptor re-expression by murine B cells.

1989 • 30 citations

Antigen binding to receptors on immunocompetent cells

1977 • 24 citations

Activation and proliferation signals in mouse B cells. VI. Anti-Ig antibodies induce dose-dependent cell cycle progression in B cells.

1985 • 22 citations

Theory of clustering of cell surface receptors by ligands of arbitrary valence: dependence of dose response patterns on a coarse cluster characteristic

1980 • 20 citations

Antibodies to surface IgM and IgD increase the expression of various class II antigens on human B cells

1985 • 19 citations

Analysis of the domain specificity of various murine anti-human IgM monoclonal antibodies differing in human B lymphocyte signaling activity

1987 • 18 citations

Anti-immunoglobulin stimulation of murine lymphocytes. IV. Re-expression and fate of cell surface receptors during stimulation.

1978 • 13 citations

Transcription of protooncogenes during stimulation of normal human B lymphocytes

1988 • 12 citations

Structure and Function of the High-Affinity Receptor for Immunoglobulin E

1990 • 12 citations

Membrane Ig-mediated triggering of B cell tolerance and B cell clonal expansion: Implications for rheumatoid factor production in rheumatoid synovitis

1989 • 5 citations