Induction of transplantation tolerance—the potential of regulatory T cells

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

2002 • 1,163 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells

2001 • 888 citations

Type 1 T regulatory cells

2001 • 829 citations

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

2002 • 800 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

2002 • 630 citations

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

1999 • 621 citations

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

2003 • 582 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

SIROLIMUS IN ASSOCIATION WITH MYCOPHENOLATE MOFETIL INDUCTION FOR THE PREVENTION OF ACUTE GRAFT REJECTION IN RENAL ALLOGRAFT RECIPIENTS12

2000 • 548 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

2000 • 448 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy

1982 • 436 citations

The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells

2002 • 408 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

Asialo GM1+ CD8+ T cells play a critical role in costimulation blockade–resistant allograft rejection

1999 • 351 citations

IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.

1998 • 275 citations

Specific suppression of T helper alloreactivity by allo-MHC class I- restricted CD8+CD28- T cells

1998 • 271 citations

Requirement for natural killer T (NKT) cells in the induction of allograft tolerance

2001 • 270 citations

Inhibition of Human CD4+CD25+high Regulatory T Cell Function

2002 • 266 citations

CD40 Ligand Blockade Induces CD4+ T Cell Tolerance and Linked Suppression

1999 • 251 citations

Human CD4+ T Lymphocytes with Remarkable Regulatory Functions on Dendritic Cells and Nickel-Specific Th1 Immune Responses

2000 • 241 citations

CD4+ regulatory T cells

2001 • 241 citations

Characterization of human CD25⁺ CD4⁺ T cells in thymus, cord and adult blood

2002 • 232 citations

Regulatory CD25+ T Cells in Human Kidney Transplant Recipients

2003 • 232 citations

IFN-γ Is Critical for Long-Term Allograft Survival Induced by Blocking the CD28 and CD40 Ligand T Cell Costimulation Pathways

1998 • 211 citations

Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance

2000 • 202 citations

Twin-to-twin pancreas transplantation: reversal and reenactment of the pathogenesis of type I diabetes.

1984 • 197 citations

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines

2002 • 194 citations

Regulatory T cells in transplantation

2002 • 189 citations

Specific Suppression of Human CD4+ Th Cell Responses to Pig MHC Antigens by CD8+CD28− Regulatory T Cells

1998 • 188 citations

CD8⁺CD28⁻ T suppressor cells and the induction of antigen‐specific, antigen‐presenting cell‐mediated suppression of Th reactivity

2001 • 185 citations

T-regulatory 1 cells: A novel subset of CD4+ T cells with immunoregulatory properties

2000 • 178 citations

Subsets of CD4⁺ T Cells and their Roles in the Induction and Prevention of Autoimmunity

1991 • 174 citations

DIFFERENTIAL EFFECTS OF CYCLOSPORINE A, METHYLPREDNISOLONE, MYCOPHENOLATE, AND RAPAMYCIN ON CD154 INDUCTION AND REQUIREMENT FOR NF??B

2000 • 161 citations

CD40-CD40 Ligand-Independent Activation of CD8+ T Cells Can Trigger Allograft Rejection

2000 • 153 citations

The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

1991 • 147 citations

COMBINED COSTIMULATION BLOCKADE PLUS RAPAMYCIN BUT NOT CYCLOSPORINE PRODUCES PERMANENT ENGRAFTMENT1

1998 • 140 citations

Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells

2002 • 137 citations

Glucocorticoids drive human CD8+ T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production

2000 • 131 citations

T suppressor lymphocytes inhibit NF-kappa B-mediated transcription of CD86 gene in APC.

1999 • 128 citations

Regulatory CD8+CD28− T cells in heart transplant recipients

2002 • 117 citations

T Suppressor Lymphocytes Inhibit NF-κB-Mediated Transcription of CD86 Gene in APC

1999 • 110 citations

Regulatory T cells: mediating compromises between host and parasite

2002 • 86 citations

A Japanese family of X-linked auto-immune enteropathy with haemolytic anaemia and polyendocrinopathy

1993 • 86 citations

INDUCTION OF XENOREACTIVE CD4+ T-CELL ANERGY BY SUPPRESSOR CD8+CD28??? T CELLS1

2000 • 80 citations

CD4+CD25+ Regulatory T Cells Do Not Significantly Contribute to Direct Pathway Hyporesponsiveness in Stable Renal Transplant Patients

2003 • 77 citations

CD8⁺CD28^– T cells: Certainties and uncertainties of a prevalent human T‐cell subset

2002 • 72 citations

Cellular basis of allograft rejection in vivo. V. Examination of the mechanisms responsible for the differing efficacy of monoclonal antibody to CD4+ T cell subsets in low- and high-responder rat strains.

1989 • 54 citations

COADMINISTRATION OF EITHER CYCLOSPORINE OR STEROIDS WITH HUMANIZED MONOCLONAL ANTIBODIES AGAINST CD80 AND CD86 SUCCESSFULLY PROLONG ALLOGRAFT SURVIVAL AFTER LIFE SUPPORTING RENAL TRANSPLANTATION IN CYNOMOLGUS MONKEYS1

2001 • 50 citations

A novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT

2000 • 35 citations

Donor cell induced CD69 expression and intracellular IL-2 and IL-4 production by peripheral blood lymphocytes isolated from kidney transplant recipients

1999 • 15 citations

Characterization of regulatory CD8+CD28- T cells in heart transplant recipients

2003 • 6 citations

CD40-CD40L independent activation of CD8+T cells can trigger allograft rejection.

2000 • 4 citations

Cited By (0)

Loading...