Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

Base sequence and helix structure variation in B and A DNA

1983 • 522 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

1990 • 460 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

1990 • 408 citations

Phase I Trial of Temozolomide Plus O⁶-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

2005 • 288 citations

Epigenetic lesions causing genetic lesions in human cancer

2000 • 256 citations

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

1982 • 227 citations

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

2000 • 219 citations

O6-benzylguanine and its role in chemotherapy.

1997 • 214 citations

Phase II Trial of Carmustine Plus O⁶-Benzylguanine for Patients With Nitrosourea-Resistant Recurrent or Progressive Malignant Glioma

2002 • 191 citations

Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects

1997 • 148 citations

Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

1999 • 147 citations

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

1998 • 138 citations

The basis for current treatment recommendations for malignant gliomas

1994 • 135 citations

Crystal structure of the human O6-alkylguanine-DNA alkyltransferase

2000 • 131 citations

Phase I Trial of Carmustine Plus O6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

2000 • 112 citations

Modulation of Mammalian O⁶-Alkylguanine-DNA Alkyltransferase in vivo by O⁶-Benzylguanine and its Effect on the Sensitivity of a Human Glioma Tumor to l-(2-chloroethyl)-3-(4-methylcyclohexyl)-l-nitrosourea

1990 • 95 citations

Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine.

1998 • 94 citations

A role for p53 in the frequency and mechanism of mutation

2002 • 87 citations

Role of polymorphisms in codons 143 and 160 of the O6-alkylguanine DNA alkyltransferase gene in lung cancer risk.

2000 • 85 citations

Cyclophosphamide resistance in medulloblastoma.

1992 • 79 citations

The effect of chemotherapy on the in vivo frequency of glycophorin A ‘null’ variant erythrocytes

1990 • 74 citations

Loss of DNA Mismatch Repair: Effects on the Rate of Mutation to Drug Resistance

1997 • 73 citations

Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine.

1996 • 68 citations

Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents.

1998 • 60 citations

Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase

1999 • 59 citations

Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair

1997 • 53 citations

Properties of mammalian O6-alkylguanine-DNA transferases

1990 • 50 citations

Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione.

1989 • 44 citations

Immunoaffinity purification of human O6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies.

1990 • 42 citations

Metabolism of the chloroethylnitrosoureas

1991 • 39 citations

Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.

2002 • 36 citations

Investigation of the Role of Tyrosine-114 in the Activity of Human O⁶-Alkylguanine-DNA Alkyltranferase

1998 • 35 citations

A Model for Tumor Response to Chemotherapy:An Integration of the Stem Cell and Somatic Mutation Hypotheses

1985 • 34 citations

Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis.

1998 • 34 citations

Specificity of bischloroethylnitrosourea-induced mutation in a Chinese hamster ovary cell line transformed to express human O6-alkylguanine-DNA alkyltransferase.

1993 • 33 citations

Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate

1998 • 31 citations

Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N'-bis(2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base excision repair genes Fpg and alpha-hOgg1: implications for protective gene therapy applications.

2001 • 29 citations

Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine‒DNA alkyltransferase insensitive to O6-benzylguanine

2000 • 27 citations

Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.

2002 • 26 citations

Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine

1999 • 26 citations

Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells.

1995 • 25 citations

Molecular pharmacology of the haloethyl nitrosoureas: Formation of 6-hydroxyethylguanine in DNA treated with BCNU (N,N1-bis[2-chloroethyl]-N-nitrosourea)

1981 • 23 citations

Cytotoxicity and Mutagenicity of Frameshift-Inducing Agent ICR191 in Mismatch Repair-Deficient Colon Cancer Cells

2000 • 22 citations

Conserved residue lysine165 is essential for the ability of O6-alkylguanine‒DNA alkyltransferase to react with O6-benzylguanine

2000 • 18 citations

Mutational specificity of 1,3-bis-(2-chloroethyl)-1-nitrosourea in a Chinese hamster ovary cell line.

1992 • 14 citations

Interaction of mammalian O6-alkylguanine-DNA alkyltransferases with O6-benzylguanine

2002 • 12 citations

Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine–DNA alkyltransferase insensitive to O6-benzylguanine

2000 • 11 citations

Conserved residue lysine165 is essential for the ability of O6-alkylguanine–DNA alkyltransferase to react with O6-benzylguanine

2000 • 7 citations