Conserved residue lysine165 is essential for the ability of O6-alkylguanine‒DNA alkyltransferase to react with O6-benzylguanine

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

1995 • 502 citations

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA

1998 • 474 citations

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

1990 • 460 citations

BASE FLIPPING

1998 • 305 citations

Structural Basis for the Excision Repair of Alkylation-Damaged DNA

1996 • 244 citations

Repair of DNA containing O ⁶ ‐alkylguanine

1992 • 241 citations

O6-benzylguanine and its role in chemotherapy.

1997 • 214 citations

Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli.

1994 • 198 citations

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase

1991 • 187 citations

Regulation of Repair of Alkylation Damage in Mammalian Genomes

1993 • 164 citations

Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli

1996 • 155 citations

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

1993 • 152 citations

Three-Dimensional Structure of a DNA Repair Enzyme, 3-Methyladenine DNA Glycosylase II, from Escherichia coli

1996 • 138 citations

Crystal structure of the human O6-alkylguanine-DNA alkyltransferase

2000 • 131 citations

Pyridyloxobutyl Adduct O⁶-[4-Oxo-4-(3-pyridyl)butyl]guanine Is Present in 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-Treated DNA and Is a Substrate for O⁶-Alkylguanine-DNA Alkyltransferase

1997 • 108 citations

Hyperthermostable Protein Structure Maintained by Intra and Inter-helix Ion-pairs in Archaeal O6-Methylguanine-DNA Methyltransferase

1999 • 96 citations

The suicidal DNA repalr methyltransferases of microbes

1992 • 94 citations

Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine.

1998 • 94 citations

Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway

1997 • 93 citations

The Croonian Lecture, 1996: Endogenous damage to DNA

1996 • 88 citations

Human Testis-Determining Factor SRY Binds to the Major DNA Adduct of Cisplatin and a Putative Target Sequence with Comparable Affinities

1998 • 80 citations

A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.

1993 • 69 citations

Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine.

1996 • 68 citations

Specific Recognition of O⁶-Methylguanine in DNA by Active Site Mutants of Human O⁶-Methylguanine-DNA Methyltransferase

1997 • 67 citations

Repair of O6-Benzylguanine by the Escherichia coli Ada and Ogt and the Human O6-Alkylguanine-DNA Alkyltransferases

1997 • 60 citations

Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine

1995 • 55 citations

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase

1996 • 53 citations

Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents

1997 • 53 citations

Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.

1996 • 37 citations

Investigation of the Role of Tyrosine-114 in the Activity of Human O⁶-Alkylguanine-DNA Alkyltranferase

1998 • 35 citations

Probing of conformational changes in human O6-alkylguanine-DNA alkyl transferase protein in its alkylated and DNA-bound states by limited proteolysis

1998 • 34 citations

Synthesis of Oligodeoxyribonucleotides Containing Analogs of O6-Methylguanine and Reaction with O6-Alkylguanine-DNA Alkyltransferase

1994 • 30 citations

Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-Bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine

1999 • 30 citations

Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine‒DNA alkyltransferase insensitive to O6-benzylguanine

2000 • 27 citations

A new model for how O6-methylguanine-DNA methyltransferase binds DNA.

1998 • 26 citations

Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.

1999 • 25 citations

Requirement of the Pro-Cys-His-Arg sequence for O6-methylguanine-DNA methyltransferase activity revealed by saturation mutagenesis with negative and positive screening

1994 • 19 citations

Enzyme Structures: DNA repair flips out

1995 • 18 citations

Specific labeling of O6-alkylguanine-DNA alkyltransferase by reaction with O6-(p-hydroxy[3H]methylbenzyl)guanine.

1995 • 11 citations

The role of two conserved amino acids, glutamine 90 and asparagine 137, in O⁶-methylguanine-DNA methyltransferase stability, activity and substrate specificity

1994 • 11 citations

Site directed mutagenesis of two cysteine residues in the E. coli OGT O6-alkylguanine DNA alkyltransferase protein

1992 • 7 citations

Novel approaches in anticancer drug design : molecular modelling - new treatm ent strategies

1995 • 5 citations