Regulatory CD25+ T Cells in Human Kidney Transplant Recipients

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996

2000 • 1,803 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality

2002 • 1,061 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Strategies to Improve Long-Term Outcomes after Renal Transplantation

2002 • 836 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

Noninvasive Diagnosis of Renal-Allograft Rejection by Measurement of Messenger RNA for Perforin and Granzyme B in Urine

2001 • 600 citations

The Role of T-Cell Costimulatory Activation Pathways in Transplant Rejection

1998 • 585 citations

Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

2001 • 580 citations

Identification of Regulatory T Cells in Tolerated Allografts

2002 • 577 citations

Certified Professionals

2001 • 533 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation

1997 • 437 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts.

1998 • 328 citations

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.

1993 • 325 citations

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action.

1990 • 302 citations

INDIRECT ALLORECOGNITION OF MAJOR HISTOCOMPATIBILITY COMPLEX ALLOPEPTIDES IN HUMAN RENAL TRANSPLANT RECIPIENTS WITH CHRONIC GRAFT DYSFUNCTION1

1997 • 290 citations

Human allograft acceptance is associated with immune regulation

2000 • 261 citations

Indirect recognition of donor HLA-DR peptides in organ allograft rejection.

1996 • 244 citations

T Cell Death and Transplantation Tolerance

2001 • 218 citations

Loss of Direct and Maintenance of Indirect Alloresponses in Renal Allograft Recipients: Implications for the Pathogenesis of Chronic Allograft Nephropathy

2001 • 207 citations

T Cell-Mediated Maintenance of Natural Self-Tolerance: its Breakdown as a Possible Cause of Various Autoimmune Diseases

1996 • 175 citations

Significant Frequencies of T Cells With Indirect Anti-Donor Specificity in Heart Graft Recipients With Chronic Rejection

2000 • 140 citations

Enzyme-Linked Immunosorbent Spot Assay Analysis of Peripheral Blood Lymphocyte Reactivity to Donor HLA-DR Peptides

2002 • 137 citations

Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy

2001 • 131 citations

Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase- reactive T cells

1999 • 129 citations

INDIRECT RECOGNITION OF DONOR HLA CLASS I PEPTIDES IN LUNG TRANSPLANT RECIPIENTS WITH BRONCHIOLITIS OBLITERANS SYNDROME1

1999 • 127 citations

Challenges to achieving clinical transplantation tolerance

2001 • 111 citations

Why do we reject a graft? Role of indirect allorecognition in graft rejection

1999 • 100 citations

The contributions of T‐cell anergy to peripheral T‐cell tolerance

2001 • 99 citations

T cells reactive to a single immunodominant self-restricted allopeptide induce skin graft rejection in mice.

1998 • 96 citations

FEATURES OF ACUTE REJECTION THAT INCREASE RISK FOR CHRONIC REJECTION1

1999 • 92 citations

Adoptively transferred CD4+ lymphocytes from CD8 -/- mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts.

1996 • 72 citations

Indirect Allorecognition of Donor Class I and II Major Histocompatibility Complex Peptides Promotes the Development of Transplant Vasculopathy

2001 • 42 citations

Prospects and applicability of molecular diagnosis of allograft rejection.

2000 • 36 citations

The role of T-cell anergy in the maintenance of donor-specific hyporesponsiveness in renal transplant recipients

2001 • 9 citations

Regulatory T Cells in Kidney Transplant Recipients

2003 • 4 citations

Achieving clinical transplant tolerance: what are the hurdles?

2001 • 1 citations

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