Achieving clinical transplant tolerance: what are the hurdles?

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

Mixed Allogeneic Chimerism And Renal Allograft Tolerance In Cynomolgus Monkeys

1995 • 552 citations

Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154

1999 • 418 citations

COMBINED HISTOCOMPATIBILITY LEUKOCYTE ANTIGENMATCHED DONOR BONE MARROW AND RENAL TRANSPLANTATION FOR MULTIPLE MYELOMA WITH END STAGE RENAL DISEASE: THE INDUCTION OF ALLOGRAFT TOLERANCE THROUGH MIXED LYMPHOHEMATOPOIETIC CHIMERISM

1999 • 418 citations

Mixed Chimerism and Transplant Tolerance

2001 • 391 citations

BOTH ALLOANTIGEN-DEPENDENT AND -INDEPENDENT FACTORS INFLUENCE CHRONIC ALLOGRAFT REJECTION

1995 • 378 citations

T cell co-stimulatory molecules other than CD28

1999 • 349 citations

BOTH ALLOANTIGEN-DEPENDENT AND -INDEPENDENT FACTORS INFLUENCE CHRONIC ALLOGRAFT REJECTION

1995 • 340 citations

Immunologic Tolerance to Renal Allografts after Bone Marrow Transplants from the Same Donors

1991 • 266 citations

T Cell Death and Transplantation Tolerance

2001 • 218 citations

FN18-CRM9 IMMUNOTOXIN PROMOTES TOLERANCE IN PRIMATE RENAL ALLOGRAFTS1

1997 • 212 citations

Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.

1999 • 209 citations

MICROCHIMERISM LINKED TO CYTOTOXIC T LYMPHOCYTE FUNCTIONAL UNRESPONSIVENESS (CLONAL ANERGY) IN A TOLERANT RENAL TRANSPLANT RECIPIENT

1995 • 186 citations

Acquired Immune Tolerance to Cadaveric Renal Allografts

1989 • 185 citations

MICROCHIMERISM LINKED TO CYTOTOXIC T LYMPHOCYTE FUNCTIONAL UNRESPONSIVENESS (CLONAL ANERGY) IN A TOLERANT RENAL TRANSPLANT RECIPIENT

1995 • 156 citations

Chronic allograft dysfunction: mechanisms and new approaches to therapy.

2000 • 128 citations

CLINICAL TRANSPLANTATION TOLERANCE TWELVE YEARS AFTER PROSPECTIVE WITHDRAWAL OF IMMUNOSUPPRESSIVE DRUGS: STUDIES OF CHIMERISM AND ANTI-DONOR REACTIVITY1

2000 • 128 citations

DENDRITIC CELLS AS REGULATORS OF IMMUNE REACTIVITY: IMPLICATIONS FOR TRANSPLANTATION1

1999 • 119 citations

Transplantation Tolerance: A Look at the Nonhuman Primate Literature in the Light of Modern Tolerance Theories

1999 • 91 citations

EVIDENCE THAT IMPROVED LATE RENAL TRANSPLANT OUTCOME CORRELATES WITH THE DEVELOPMENT OF IN VITRO DONOR ANTIGEN-SPECIFIC HYPOREACTIVITY

1993 • 88 citations

In Search of the Elusive Holy Grail: the Mechanisms and Prospects for Achieving Clinical Transplantation Tolerance

2001 • 82 citations

POSTTRANSPLANT DIASTOLIC HYPERTENSION

1997 • 46 citations

Tolerance and chronic rejection

2001 • 38 citations

Prospects and applicability of molecular diagnosis of allograft rejection.

2000 • 36 citations

Transplantation tolerance: fooling mother nature.

1996 • 29 citations