The Role of Cholesterol and Statins in Alzheimer's Disease

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

1998 • 1,795 citations

Statins and the risk of dementia

2000 • 1,741 citations

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

2000 • 1,415 citations

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

1997 • 1,380 citations

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

1998 • 1,139 citations

Drug Treatment of Lipid Disorders

1999 • 863 citations

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease

1999 • 777 citations

High-Density Lipoproteins Inhibit Cytokine-Induced Expression of Endothelial Cell Adhesion Molecules

1995 • 759 citations

Serum Total Cholesterol, Apolipoprotein E {FC12}e4 Allele, and Alzheimer’s Disease

1998 • 669 citations

Vascular risk factors for Alzheimer’s disease:

2000 • 657 citations

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation.

1996 • 642 citations

Apolipoprotein E ϵ4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease

2002 • 630 citations

Use of Lipid-Lowering Agents, Indication Bias, and the Risk of Dementia in Community-Dwelling Elderly People

2002 • 519 citations

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

1998 • 508 citations

Serum Lipoprotein Levels, Statin Use, and Cognitive Function in Older Women

2002 • 432 citations

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26‐week randomized, placebo‐controlled, double‐blind trial

2002 • 417 citations

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

2000 • 374 citations

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease

1995 • 372 citations

New Perspectives on Alzheimer's Disease

1986 • 349 citations

The importance of inflammatory mechanisms in alzheimer disease

1998 • 325 citations

Fibrillogenesis in Alzheimer's disease of amyloid β peptides and apolipoprotein E

1995 • 255 citations

The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system

1993 • 251 citations

Elevation of Plasma High-Density Lipoprotein Concentration Reduces Interleukin-1–Induced Expression of E-Selectin in an In Vivo Model of Acute Inflammation

2001 • 238 citations

The Impact of the Use of Statins on the Prevalence of Dementia and the Progression of Cognitive Impairment

2002 • 189 citations

Association between high‐density lipoprotein and cognitive impairment in the oldest old

2002 • 184 citations

Biochemical markers related to Alzheimer’s dementia in serum and cerebrospinal fluid

2002 • 168 citations

Neuropathological Diagnosis of Alzheimer’s Disease: A Perspective from Longitudinal Clinicopathological Studies

1997 • 168 citations

ALZHEIMER'S DISEASE AND RELATED DISORDERS

2001 • 158 citations

Reduction of Plasma 24S-Hydroxycholesterol (Cerebrosterol) Levels Using High-Dosage Simvastatin in Patients With Hypercholesterolemia

2002 • 152 citations

Clinical Diagnosis and Management of Alzheimer's Disease

2006 • 145 citations

Plasma 24S-hydroxycholesterol

2000 • 140 citations

Removal of cholesterol from extrahepatic sources by oxidative mechanisms

1999 • 133 citations

HMG-CoA reductase inhibitors (statins)

2000 • 114 citations

Association between Alzheimer's disease and theNOS3 gene

1999 • 98 citations

High Density Lipoprotein Inhibits Assembly of Amyloid β-Peptides into Fibrils

2000 • 71 citations

Aberrant expression of nitric oxide synthase III in Alzheimer’s disease: relevance to cerebral vasculopathy and neurodegeneration

2000 • 58 citations

Apolipoprotein E Genotype and Lipid and Lipoprotein Levels in Dementia

2000 • 38 citations