Neuronal Structure is Altered by Amyloid Plaques

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

1984 • 2,199 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

2000 • 1,954 citations

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

1996 • 1,734 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

2000 • 1,433 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

2003 • 1,373 citations

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1994 • 1,313 citations

Structure and function of declarative and nondeclarative memory systems

1996 • 1,298 citations

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1994 • 1,213 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

2003 • 1,027 citations

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1999 • 917 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

2002 • 858 citations

Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

1999 • 797 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

Alzheimer's Disease: A Central Role for Amyloid

1994 • 749 citations

Altered expression of synaptic proteins occurs early during progression of Alzheimer’s disease

2001 • 666 citations

Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

2004 • 617 citations

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

1987 • 602 citations

Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease

2004 • 559 citations

Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

1997 • 535 citations

Dendritic Growth in the Aged Human Brain and Failure of Growth in Senile Dementia

1979 • 466 citations

Plasticity of Hippocampal Circuitry in Alzheimer's Disease

1985 • 457 citations

Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

2001 • 453 citations

Quantitative assessment of cortical synaptic density in Alzheimer's disease

1990 • 415 citations

Correlations of synaptic and pathological markers with cognition of the elderly

1995 • 405 citations

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

2003 • 384 citations

Imaging Aβ Plaques in Living Transgenic Mice with Multiphoton Microscopy and Methoxy-X04, a Systemically Administered Congo Red Derivative

2002 • 380 citations

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

1996 • 373 citations

Synaptic slaughter in Alzheimer's disease

2003 • 340 citations

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

1988 • 308 citations

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

1996 • 301 citations

Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice

2003 • 257 citations

Synapse loss in the temporal lobe in Alzheimer's disease

1993 • 247 citations

Neuronal Changes in Normal Human Aging and Alzheimer's Disease

2002 • 246 citations

Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease

2002 • 232 citations

Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype

2003 • 222 citations

Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia

1981 • 218 citations

Defects in expression of genes related to synaptic vesicle traffickingin frontal cortex of Alzheimer’s disease

2003 • 211 citations

Toxicity of Amyloid β Peptide: Tales of Calcium, Mitochondria, and Oxidative Stress

2004 • 207 citations

Cortical Synaptic IntegrationIn VivoIs Disrupted by Amyloid-β Plaques

2004 • 203 citations

Neuritic plaques in senile dementia of Alzheimer type: a Golgi analysis in the hippocampal region

1983 • 194 citations

Three-Dimensional Analysis of the Relationship Between Synaptic Pathology and Neuropil Threads in Alzheimer Disease

1992 • 180 citations

The Contribution of Altered Synapses in the Senile Plaque: An Electron Microscopic Study in Alzheimer's Dementia^*†

1967 • 179 citations

Regional synaptic pathology in Alzheimer's disease

1992 • 176 citations

Miliare Nekrosen mit drusigen Wucherungen der Neurofibrillen, eine regelmässige Veränderung der Hirnrinde bei seniler Demenz.

1907 • 176 citations

Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization

2001 • 169 citations

Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex.

1994 • 166 citations

Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia

1987 • 164 citations

Neuroplasticity in Alzheimer's disease

2002 • 163 citations

Senile plaques as aberrant sprout-stimulating structures

1986 • 161 citations

Synaptic pathology in alzheimer's disease: Immunological data for markers of synaptic and large dense-core vesicles

1992 • 159 citations

Amyloid-β Antibody Treatment Leads to Rapid Normalization of Plaque-Induced Neuritic Alterations

2003 • 150 citations

Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease

2002 • 149 citations

Morphometric and dendritic analysis of fascia dentata granule cells in human aging and senile dementia

1987 • 145 citations

Induction of Brain-Derived Neurotrophic Factor in Plaque-Associated Glial Cells of Aged APP23 Transgenic Mice

2004 • 127 citations

Dendritic changes in Alzheimer's disease and factors that may underlie these changes

1998 • 116 citations

Dendritic changes in the basal nucleus of meynert and in the diagonal band nucleus in Alzheimer's disease—A quantitative Golgi investigation

1986 • 113 citations

Imaging Amyloid-β Deposits In Vivo

2002 • 107 citations

Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease

2001 • 105 citations

Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques

1994 • 98 citations

Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. I. CA1 of hippocampus

1991 • 92 citations

Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. II. Subiculum

1991 • 90 citations

Synaptic Density in the Inner Molecular Layer of the Hippocampal Dentate Gyrus in Alzheimer Disease

1998 • 89 citations

In Vivo Multiphoton Imaging of a Transgenic Mouse Model of Alzheimer Disease Reveals Marked Thioflavine-S-Associated Alterations in Neurite Trajectories

2003 • 89 citations

Alzheimer's disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain

2000 • 88 citations

Synaptic Pathology of Alzheimer's Diseasea

1993 • 86 citations

Expression profiles of multiple genes in single neurons of Alzheimer’s disease

1998 • 86 citations

A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease

1990 • 85 citations

Neuronal alterations in patients with dementia: a Golgi study on biopsy samples

1990 • 83 citations

Chapter 31 Chapter Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease

1990 • 83 citations

Subicular Dendritic Arborization in Alzheimer's Disease Correlates with Neurofibrillary Tangle Density

2003 • 82 citations

EM study of the numbers of cortical synapses in the brains of ageing people and people with Alzheimer-type dementia

1983 • 81 citations

Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease

1993 • 80 citations

Dendritic extent in human CA2–3 hippocampal pyramidal neurons in normal aging and senile dementia

1987 • 79 citations

Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies.

2003 • 78 citations

Identification and distribution of axonal dystrophic neurites in Alzheimer's disease

1993 • 74 citations

Decreased numbers of dendritic spines on cortical pyramidal neurons in dementia. A quantitative Golgi study on biopsy samples.

1988 • 71 citations

Alzheimer's disease-related synapse loss in the cingulate cortex

2001 • 66 citations

Deterioration threshold of synaptic morphology in aging and senile dementia of Alzheimer's type.

1996 • 65 citations

Hyperactivation of Signal Transduction Systems in Alzheimer's Diseasea

1993 • 59 citations

Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease

1990 • 59 citations

Progressive Reduction of Synaptophysin Message in Single Neurons in Alzheimer Disease

2002 • 58 citations

Alzheimer's disease-like dystrophic neurites characteristically associated with senile plaques are not found within other neurodegenerative disease unless amyloid β-protein deposition is present

1993 • 55 citations

Chapter 30 Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms?

1990 • 47 citations

Growth of abnormal neurites in atypical Alzheimer's disease

1983 • 47 citations

Chapter 4 Age-related changes in Down syndrome brain and the cellular pathology of Alzheimer disease

1986 • 39 citations

The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer disease brain

2003 • 35 citations

Computer-Assisted Morphometry of Synaptic Plasticity during Aging and Dementia

1989 • 35 citations

Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies.

2003 • 34 citations

Alzheimer’s Disease: What Multiphoton Microscopy Teaches Us

2002 • 25 citations

The Brain's Microenvironment, Early Functional Loss, and the Conversion to Alzheimer's Disease

2000 • 21 citations

Chapter 7 Neuronal plasticity in normal aging and deficient plasticity in Alzheimer's disease: a proposed intercellular signal cascade

1990 • 21 citations

Synaptic Structure and Function in Transgenic APP Mice

2000 • 13 citations