PYY3‐36 as an anti‐obesity drug target

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

Gut hormone PYY3-36 physiologically inhibits food intake

2002 • 2,263 citations

Inhibition of Food Intake in Obese Subjects by Peptide YY_3–36

2003 • 1,549 citations

Human distribution and release of a putative new gut hormone, peptide YY

1985 • 1,063 citations

A receptor subtype involved in neuropeptide-Y-induced food intake

1996 • 892 citations

Stress-induced eating.

1994 • 847 citations

Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides

1980 • 645 citations

Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia

2003 • 464 citations

Role of the Y5 neuropeptide Y receptor in feeding and obesity

1998 • 419 citations

Minireview: Glucocorticoids—Food Intake, Abdominal Obesity, and Wealthy Nations in 2004

2004 • 396 citations

Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor

1998 • 391 citations

Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion

1985 • 386 citations

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY _3-36

2004 • 363 citations

Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance

2003 • 341 citations

Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect

1992 • 288 citations

Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor

1999 • 276 citations

Ghrelin, Peptide YY, Glucose-Dependent Insulinotropic Polypeptide, and Hunger Responses to a Mixed Meal in Anorexic, Obese, and Control Female Adolescents

2005 • 274 citations

Reduced central leptin sensitivity in rats with diet-induced obesity

2002 • 266 citations

Distribution of pancreatic polypeptide and peptide YY

2002 • 254 citations

Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice

2002 • 245 citations

Acute effects of PYY3–36 on food intake and hypothalamic neuropeptide expression in the mouse

2003 • 242 citations

Role of the Y1 Receptor in the Regulation of Neuropeptide Y-Mediated Feeding: Comparison of Wild-Type, Y1 Receptor-Deficient, and Y5 Receptor-Deficient Mice

2000 • 239 citations

Peptide YY_3–36Inhibits Food Intake in Mice through a Melanocortin-4 Receptor-Independent Mechanism

2004 • 238 citations

Neuropeptide Y family of peptides: Structure, anatomical expression, function, and molecular evolution

2000 • 225 citations

Intravenous Infusion of Peptide YY(3–36) Potently Inhibits Food Intake in Rats

2004 • 224 citations

Effects of PYY[3–36] in rodent models of diabetes and obesity

2004 • 213 citations

Peptide YY(3–36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys

2004 • 187 citations

Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains

1998 • 186 citations

Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake.

1996 • 185 citations

Peripheral administration of PYY3–36 produces conditioned taste aversion in mice

2005 • 185 citations

Multiple Receptors for the Pancreatic Polypeptide (PP-Fold) Family: Physiological Implications

1998 • 180 citations

Characterization of Blood-Brain Barrier Permeability to PYY_3-36 in the Mouse

2003 • 179 citations

Effects of Peptide YY and Neuropeptide Y on Gastric Emptying in Man

1984 • 166 citations

Autoradiographic distribution of [125I]Leu31,Pro34]PYY and [125I]PYY3-36 binding sites in the rat brain evaluated with two newly developed Y1 and Y2 receptor radioligands

1996 • 157 citations

Differences in daily stress, mood, coping, and eating behavior in binge eating and nonbinge eating college women

2000 • 153 citations

Analysis of neuropeptide Y-induced feeding: Dissociation of Y1 and Y2 receptor effects on natural meal patterns

1991 • 149 citations

Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism

2001 • 143 citations

Expression and Characterization of the Neuropeptide Y Y₅Receptor Subtype in the Rat Brain

1998 • 142 citations

Peptide YY (PYY), a poteny orexigenic agent

1985 • 134 citations

Peptide YY-like immunoreactivity in the central nervous system of the rat

1986 • 133 citations

Structure and receptor binding of PYY analogs

2002 • 117 citations

Beneficial effects of GH/IGF-1 on skeletal muscle atrophy and function in experimental heart failure

2004 • 104 citations

Effect of fourth ventricular neuropeptide Y and peptide YY on ingestive and other behaviors

1990 • 100 citations

A Comparison of Intraduodenally and Intracolonically Administered Nutrients on the Release of Peptide-YY in the Dog*

1989 • 91 citations

Peptide YY (PYY)‐immunoreactive neurons in the lower brain stem and spinal cord of rat

1985 • 88 citations

Characterization of neuropeptide Y-induced feeding in mice: do Y1-Y6 receptor subtypes mediate feeding?

1999 • 77 citations

Autoreceptor-induced inhibition of neuropeptide Y release from PC-12 cells is mediated by Y₂receptors

1997 • 75 citations

Peptide YY: a key mediator of orexigenic behavior

2002 • 62 citations

Centrally administered neuropeptide Y delays gastric emptying via Y₂receptors in rats

2001 • 62 citations

Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY3–36 but resistant to ghrelin

2004 • 61 citations

Peptide YY: A neuropeptide in the gut. Immunocytochemical and immunochemical evidence

1993 • 58 citations

Curve-shift analysis of self-stimulation in food-restricted rats: relationship between daily meal, plasma corticosterone and reward sensitization

1995 • 58 citations

Central inhibitory action of peptide YY on gastric motility in rats

1995 • 56 citations

Enhancement of feeding suppression by PYY3-36 in rats with area postrema ablations

2004 • 56 citations

Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor?

1998 • 55 citations

Dissociation of charge movement from calcium release and calcium current in skeletal myotubes by gabapentin

2002 • 54 citations

Braiding patterns on an inclined plane

2004 • 53 citations

Chronic Neuropeptide Y Infusion into the Lateral Ventricle Induces Sustained Feeding and Obesity in Mice Lacking Either Npy1r or Npy5r Expression

2003 • 51 citations

Rapid changes in hypothalamic neuropeptide Y produced by carbohydrate-rich meals that enhance corticosterone and glucose levels1This manuscript is dedicated to my eminent colleague and dear friend, Dr. Stelios Nicolaidis, who has made so many outstanding contributions and been an enormous inspiration to scientists in the fields of neuroscience and ingestive behavior.1

1999 • 50 citations

Neuropeptide Y induces fasted pattern of duodenal motility via Y₂ receptors in conscious fed rats

2000 • 49 citations

Plasma Levels of Peptide YY Correlate with Cisplatin-induced Emesis in Dogs

1994 • 38 citations

Identification and characterization of the emetic effects of peptide YY

1989 • 38 citations

Regulation of expression of neuropeptide Y Y1 and Y2 receptors in the arcuate nucleus of fasted rats

1998 • 36 citations

POWPAL: A Program for Estimating Effect Sizes, Statistical Power, and Sample Sizes

1995 • 32 citations

The area postrema lesions alter the inhibitory effects of peripherally infused pancreatic polypeptide on pancreatic secretion

2001 • 31 citations

Stimulation of NPY Y₂ receptors by PYY_3-36 reveals divergent cardiovascular effects of endogenous NPY in rats on different dietary regimens

2004 • 16 citations

Can food intake be reduced with peptide YY3-36?

2004 • 6 citations