Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY _3-36

Central nervous system control of food intake

2000 • 6,305 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Gut hormone PYY3-36 physiologically inhibits food intake

2002 • 2,263 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

Inhibition of Food Intake in Obese Subjects by Peptide YY_3–36

2003 • 1,549 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

1996 • 1,301 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

1998 • 1,139 citations

The Need to Feed

2002 • 1,089 citations

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1999 • 1,000 citations

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

2000 • 878 citations

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

1993 • 873 citations

Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity

1986 • 856 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

2001 • 617 citations

Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat

2003 • 553 citations

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

1999 • 549 citations

Activation of Central Melanocortin Pathways by Fenfluramine

2002 • 481 citations

A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

1997 • 443 citations

A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10

1998 • 385 citations

Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Melanocortin-4 Receptor Promoter

2003 • 362 citations

A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors

2000 • 360 citations

Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling

2001 • 333 citations

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat

2001 • 332 citations

The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin

2000 • 257 citations

Acute effects of PYY3–36 on food intake and hypothalamic neuropeptide expression in the mouse

2003 • 242 citations

Independent and Additive Effects of Central POMC and Leptin Pathways on Murine Obesity

1997 • 242 citations

Minireview: Human Obesity—Lessons from Monogenic Disorders

2003 • 224 citations

Induction of Neuropeptide Y Gene Expression in the Dorsal Medial Hypothalamic Nucleus in Two Models of theAgoutiObesity Syndrome

1997 • 207 citations

Chronic intracerebroventricular infusion of MCH causes obesity in mice

2003 • 204 citations

Normal Variation in Leptin Levels Is Associated with Polymorphisms in the Proopiomelanocortin Gene,POMC¹

1999 • 126 citations

Autoimmune Disorders of Neuronal Potassium Channels

2003 • 125 citations

Characterization of a Serine Protease that Cleaves Pro-γ-Melanotropin at the Adrenal to Stimulate Growth

2001 • 122 citations

Direct Measurement of the Precursors of Adrenocorticotropin in Human Plasma by Two-Site Immunoradiometric Assay*

1988 • 111 citations

Differential Regulation of Melanin-Concentrating Hormone and Orexin Genes in the Agouti-Related Protein/Melanocortin-4 Receptor System

2000 • 87 citations

Corticosterone differentially modulates expression of corticotropin releasing factor and arginine vasopressin mRNA in the hypothalamic paraventricular nucleus following either acute or repeated restraint stress

2001 • 69 citations

Lack of Proopiomelanocortin Peptides Results in Obesity and Defective Adrenal Function but Normal Melanocyte Pigmentation in the Murine C57BL/6 Genetic Background

2003 • 55 citations

Disproportionate Inhibition of Feeding in <i>A<sup>y</sup></i> Mice by Certain Stressors: A Cautionary Note

2000 • 46 citations