Experimental systems for analysis of the malignant phenotype

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

The pathogenesis of cancer metastasis

1980 • 1,750 citations

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

1977 • 1,422 citations

Selection of Successive Tumour Lines for Metastasis

1973 • 1,360 citations

Angiogenesis in vitro

1980 • 1,041 citations

Metastasis: Quantitative Analysis of Distribution and Fate of Tumor Emboli Labeled With <sup>125</sup>I-5-Iodo-2′ -deoxyuridine<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1970 • 990 citations

Tumor heterogeneity and the biology of cancer invasion and metastasis.

1978 • 833 citations

The Biology of Cancer Invasion and Metastasis

1978 • 819 citations

Natural Cell-mediated Immunity Against Tumors

1980 • 666 citations

Heterogeneity of tumor cells from a single mouse mammary tumor.

1978 • 582 citations

Role of organ selectivity in the determination of metastatic patterns of B16 melanoma.

1980 • 417 citations

Fundamental Aspects of Metastasis

1977 • 412 citations

In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties.

1980 • 408 citations

The selection and characterization of an invasive variant of the B16 melanoma.

1979 • 376 citations

Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells.

1981 • 304 citations

Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms.

1981 • 291 citations

Interactions of tumor cells with vascular endothelial cell monolayers: a model for metastatic invasion.

1979 • 270 citations

Cloning of Human Tumor Stem Cells

1981 • 269 citations

Arrest and metastasis of blood-borne tumor cells are modified by fusion of plasma membrane vesicles from highly metastatic cells.

1980 • 261 citations

Development and Biologic Properties of Malignant Cell Sublines and Clones of a Spontaneously Metastasizing Rat Mammary Adenocarcinoma<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 253 citations

Pathogenesis of metastasis formation observed in vivo in the rabbit ear chamber.

1958 • 252 citations

Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin.

1978 • 248 citations

Organizational behavior of human umbilical vein endothelial cells.

1982 • 238 citations

Solubilization and degradation of subendothelial matrix glycoproteins and proteoglycans by metastatic tumor cells.

1982 • 222 citations

Destruction of extracellular matrices containing glycoproteins, elastin, and collagen by metastatic human tumor cells.

1980 • 221 citations

Shedding from the Cell Surface of Normal and Cancer Cells

1980 • 215 citations

Metastatic tumor cells adhere preferentially to the extracellular matrix underlying vascular endothelial cells

1980 • 212 citations

New method for preparing large surfaces of intact human basement membrane for tumor invasion studies

1980 • 207 citations

Organ specificity of blood-borne tumour metastasis determined by cell adhesion?

1975 • 207 citations

The Nude mouse in experimental and clinical research

1978 • 205 citations

Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin.

1981 • 195 citations

Role of natural killer cells in control of cancer metastasis

1982 • 190 citations

The implications of tumor heterogeneity for studies on the biology and therapy of cancer metastasis

1981 • 182 citations

Expression of metastatic potential of tumor cells in young nude mice is correlated with low levels of natural killer cell‐mediated cytotoxicity

1980 • 179 citations

Effects of tunicamycin on B16 metastatic melanoma cell surface glycoproteins and blood-borne arrest and survival properties.

1981 • 178 citations

Characterization in vivo and in vitro of tumor cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity.

1976 • 175 citations

Selection and altered properties of brain-colonising metastatic melanoma

1978 • 171 citations

Proteinases and tumor invasion

1980 • 170 citations

Studies correlating the growth rate of a tumor and its metastases and providing evidence for tumor-related systemic growth-retarding factors.

1972 • 167 citations

Cancer metastasis: A product of tumor-host interactions

1979 • 164 citations

Tumor metastases and cell‐mediated immunity in a model system in DBA/2 mice. I. Tumor invasiveness in vitro and metastasis formation in vivo

1979 • 159 citations

Metastatic behavior of a murine reticulum cell sarcoma exhibiting organ-specific growth.

1981 • 154 citations

The Choice of Animal Tumors for Experimental Studies of Cancer Therapy

1978 • 143 citations

Relationship Between Metastatic Potential and Resistance to Natural Killer Cellmediated Cytotoxicity in Three Murine Tumor Systems2, 3

1981 • 142 citations

Correlation of the production of plasminogen activator with tumor metastasis in B16 mouse melanoma cell lines.

1980 • 138 citations

Selection and Biologic Properties of Malignant Variants of a Murine Lymphosarcoma<xref ref-type="fn" rid="FN2">2</xref>

1978 • 138 citations

Cancer invasion and metastasis : biologic mechanisms and therapy

1977 • 135 citations

The fate of circulating tumors cells. I. Passage of cells through capillaries.

1961 • 130 citations

The extracellular matrix and the control of proliferation of vascular endothelial and vascular smooth muscle cells

1980 • 129 citations

Distinct lung-colonizing and lung-metastasizing cell populations in B16 mouse melanoma

1981 • 128 citations

Growth interaction in vivo between tumor subpopulations derived from a single mouse mammary tumor.

1980 • 128 citations

Analysis of Antigenic Heterogeneity Within Individual 3-Methylcholanthrene-Induced Mouse Sarcomas<xref ref-type="fn" rid="FN2">2</xref>

1970 • 126 citations

Relationship of host immune status to tumor cell arrest, distribution, and survival in experimental metastasis

1977 • 125 citations

Current problems in cancer

2003 • 124 citations

Cloning of human tumor stem cells

1980 • 119 citations

Barrier function of lymph node to tumor cells and erythrocytes.I. Normal nodes

1967 • 117 citations

Teratocarcinomas and Other Neoplasms as Developmental Defects in Gene Expression

1981 • 109 citations

Expression of metastatic potential of allogenic and xenogeneic neoplasms in young nude mice.

1981 • 109 citations

Differences in Cell Surface Antigens of Tumor Metastases and Those of the Local Tumor2

1979 • 108 citations

Cancer cell traffic from the lungs to the liver: An example of metastatic inefficiency

1980 • 108 citations

Comparison of the metastatic properties of B16 melanoma clones isolated from cultured cell lines, subcutaneous tumors, and individual lung metastases.

1982 • 106 citations

Metastasizing capacity of tumour cells from spontaneous metastases of transplanted murine tumours

1980 • 106 citations

Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection

1975 • 101 citations

Regional Differences in the Growth of Normal and Neoplastic Cells

1982 • 100 citations

Selection and In Vivo Properties of Lectin-Attachment Variants of Malignant Murine Lymphosarcoma Cell Lines<xref ref-type="fn" rid="FN2">2</xref>

1980 • 99 citations

The origin of metastatic heterogeneity in tumors

1981 • 98 citations

Metastasizing Mammary Carcinomas in Rats: Induction and Study of Their Immunogenicity

1970 • 96 citations

Tumor cell antigenicity, host immunity, and cancer metastasis

1980 • 96 citations

Malignancies of metastatic murine lymphosarcoma cell lines and clones correlate with decreased cell surface display of RNA tumor virus envelope glycoprotein gp70.

1980 • 95 citations

Liver-colonizing melanoma cells selected from B-16 melanoma

1979 • 93 citations

Cancer Invasion and Metastasis

1980 • 92 citations

Isolation and Metastatic Properties of Detachment Variants of 816 Melanoma Cells 2

1978 • 90 citations

Tumor Metastasis Is Not Due to Adaptation of Cells to a New Organ Environment

1982 • 89 citations

Induction of a tumor with greatly increased metastatic growth potential by injection of cells from a low‐metastatic H‐2 heterozygous tumor cell line into an H‐2 incompatible parental strain

1978 • 87 citations

Design of models for testing cancer therapeutic agents

1982 • 85 citations

The organ distribution of disseminated 51 Cr-labeled tumor cells.

1967 • 84 citations

Preferential sites of growth of human tumors in nude mice following subcutaneous transplantation.

1980 • 84 citations

An in vitro quantitative assay for tumor cell invasion.

1978 • 83 citations

Hepatocyte-tumor cell interaction in vitro. I. Conditions for rosette formation and inhibition by anti-H-2 antibody.

1980 • 83 citations

Specific immunotherapy of established visceral micrometastases by BCG-tumor cell vaccine alone or as an adjunct to surgery

1978 • 83 citations

Selection of malignant melanoma variant cell lines for ovary colonization

1979 • 83 citations

Organ vascularity and metastatic frequency.

1980 • 82 citations

Transplantable Metastasizing Prostate Adenocarcinomas in Rats<xref ref-type="fn" rid="fn2">2</xref>

1975 • 82 citations

Characterization of a murine ovarian reticulum cell sarcoma of histiocytic origin.

1981 • 80 citations

The fine structure of neoplastic invasion: Invasion of liver, skeletal muscle and lymphatic vessels by the Rd/3 tumour

1976 • 79 citations

Biological and experimental consequences of the zonal composition of solid tumors.

1981 • 79 citations

The development of spontaneous metastases after the removal of a “primary” tumorII. Standardization protocol of 5 animal tumors

1961 • 78 citations

Gradual transformation of solid into ascites tumors. Evidence favoring the mutation-selection theory

1955 • 78 citations

Use of in Vitro Tests in Predlctlve Cancer Chemotherapy

1981 • 77 citations

In vitro systems for evaluation of combination chemotherapy

1980 • 77 citations

Antigenic differences between primary methylcholanthrene‐induced rat sarcomas and post‐surgical recurrences

1977 • 72 citations

Tumor heterogeneity and stability of the metastatic phenotype of mouse KHT sarcoma cells.

1981 • 72 citations

In Vivo Isolation of a Metastatic Tumor Cell Variant Involving Selective and Nonadaptive Processes<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>

1981 • 71 citations

THE RELATIONSHIP BETWEEN THE DISSEMINATION OF TUMOR CELLS AND THE DISTRIBUTION OF METASTASES.

1964 • 70 citations

Metastatic colonization potential of primary tumour cells in mice

1979 • 67 citations

Murine melanoma: a model for intracranial metastasis

1980 • 67 citations

ON THE PRESENCE WITHIN TUMOURS OF CLONES THAT DIFFER IN SENSITIVITY TO CYTOSTATIC DRUGS

1974 • 65 citations

Characterization of tumor lines derived from spontaneous metastases of a transplanted murine sarcoma

1981 • 60 citations

The Histologic Analysis of Mammary Tumors of Mice. II. The Histology of Responsiveness and Progression. The Origins of Tumors<xref ref-type="fn" rid="fn1">2</xref>

1956 • 59 citations

The interaction of platelets, tumor cells, and vascular subendothelium.

1980 • 57 citations

Quantitative studies of translymphnodal passage of tumour cells naturally disseminated from a non-immunogenic murine squamous carcinoma

1975 • 57 citations

Loss of malignancy during serial passage of human carcinoma in culture and discordance between malignancy and transformation parameters.

1980 • 53 citations

Secondary spread of cancer

1978 • 53 citations

In vivo-in vitro tumour cell lines: characteristics and limitations as models for human cancer.

1980 • 52 citations

Malignant mouse melanoma cells do not form tumors when mixed with cells of a non‐malignant subclone: Relationships between plasminogen activator expression by the tumor cells and the host's immune response

1978 • 51 citations

Comparative study on the effects of surgery, chemotherapy, and immunotherapy, alone and in combination, on metastases of the 13762 mammary adenocarcinoma.

1974 • 50 citations

Differentiation and Neoplasia

1980 • 50 citations

In Vitro Methods to Predict for Patient Response to Chemotherapy

1980 • 49 citations

Activated macrophages digest the extracellular matrix proteins produced by cultured cells

1979 • 47 citations

An electron microscopic study of pulmonary tumor emboli from transplantable Morris hepatoma 5123.

1967 • 47 citations

Is invasiveness in vitro characteristic of malignant cells ?

1979 • 47 citations

Biologic Manifestations of Oncogenesis In Vitro: A Critique1

1974 • 43 citations

FUNDAMENTAL ASPECTS OF METASTASES

1976 • 42 citations

Clonal variation and functional correlation of organ‐specific metastasis and an organ‐specific metastasis‐associated antigen

1981 • 41 citations

Human tumour xenografts: a critical appraisal.

1980 • 40 citations

Zur Frage der Metastasenbildung bei Impftumoren

1939 • 40 citations

Cell interactions in the metastatic process: some cell surface properties associated with successful blood-borne tumor spread.

1977 • 40 citations

Retained regional lymph nodes: Effect on metastases and recurrence after tumor removal

1970 • 39 citations

Invasion of an artificial blood vessel wall by human fibrosarcoma cells.

1981 • 37 citations

In vitro characteristics of metastatic variant subclones of restricted genetic origin

1981 • 37 citations

A rapid method for the isolation of metastasizing tumour cells from internal organs with the help of isopycnic density-gradient centrifugation in Percoll

1981 • 36 citations

The role of glycoconjugates in metastatic melanoma blood‐borne arrest and cell surface properties

1981 • 36 citations

Deformability of Normal and Sickle Erythrocytes in a Pressure-flow Filtration System

1978 • 36 citations

Evidence for Mononuclear Phagocytes in Solid Neoplasms and Appraisal of Their Nonspecific Cytotoxic Capabilities

1980 • 34 citations

Conversion of a Poorly Differentiated Human Adenocarcinoma to Ascites Form With Invasion and Metastasis in Nude Mice: Brief Communication

1978 • 34 citations

THE PLATING OF TUMOR COMPONENTS ON THE SUBCUTANEOUS EXPANSES OF YOUNG MICE

1962 • 34 citations

Cell Movement and Neoplasia

1980 • 32 citations

Cells transformed by temperature-sensitive mutants of avian sarcoma virus cause tumors in vivo at permissive and nonpermissive temperatures

1979 • 31 citations

Biochemical mechanisms involved in tumor cell penetration of the basement membrane

1982 • 30 citations

Experiments on lymph node metastasis by intralymphatic inoculation of rat ascites tumor cells, with special reference to lodgement, passage, and growth of tumor cells in lymph nodes.

1970 • 30 citations

Das spinale Neurinom und sympathische Ganglioneurom im Kindesalter.

1947 • 29 citations

A study of variation and progression in oncongenicity in an SV 40-transformed hamster heart cell line and its clones

1969 • 29 citations

Microcirculation of the lymph node with metastases.

1976 • 27 citations

Experimental studies on the spread of cancer in the lymphatic system. IV. Retrograde spread.

1959 • 26 citations

The deformability of bhk cells and polyoma virus-transformed bhk cells in relation to locomotory behaviour

1980 • 24 citations

Demonstration of a correlation between tumor cell H-2 antigen content, immunogenicity, and tumorigenicity using lectin-resistant tumor variants.

1981 • 24 citations

Endothelial cell alloantigens.

1980 • 23 citations

Transformation-induced alterations in adhesion

1976 • 22 citations

A morphometrical analysis of lymph node responses to tumors of different immunogenicity.

1978 • 22 citations

Shear-induced concanavalin A agglutination of human erythrocytes

1979 • 21 citations

Liposomes, drugs and immunocompetent cell functions

1982 • 21 citations

Liposome-mediated transfer of integral membrane glycoproteins into the plasma membrane of cultured cells

1980 • 20 citations

THE MULTICELLULAR SPHEROID AS A MODEL TUMOR ALLOGRAFT

1978 • 20 citations

Sorting out of normal and virus-transformed cells in cellular aggregates.

1976 • 20 citations

Lymph‐node metastases after intratibial transplantation of tumors

1968 • 19 citations

Methods and models for studying tumor invasion

1982 • 19 citations

THE MULTICELLULAR SPHEROID AS A MODEL TUMOR ALLOGRAFT

1978 • 18 citations

Development of a neonatal and metastatic murine neuroblastoma model.

1979 • 18 citations

The activity of regional nodes in the evolution of immune responses to allogeneic and isogeneic tumors.

1975 • 18 citations

Quantitative Assay for Lectin-Induced Cytoagglutination by Means of an Electronic Particle-Counting Technique 234

1981 • 18 citations

Patterns of spontaneous metastasis of transplantable hepatocellular carcinomas.

1978 • 17 citations

Regional differences in the growth of tumor cells injected intraperitoneally into syngeneic adult mice.

1980 • 17 citations

Lymphatic system metastasis

1980 • 16 citations

Biologic and immunologic studies on a murine model of regional lymph node metastasis.

1980 • 16 citations

Destruction of regional lymph node metastases of rat mammary adenocarcinoma 13762A by treatment with Corynebacterium parvum.

1978 • 16 citations

Separation of Individual Kinds of Cells from Tumors

1980 • 15 citations

Labelling of lymphocytes with various radioisotopes for in vivo tracer studies; A review

1977 • 15 citations

Malignant properties and DNA content of daughter clones from a mouse fibrosarcoma: differentiation between malignant properties

1980 • 14 citations

Contact inhibition and the movement of metal, glass and plastic beads within solid tissues

1977 • 14 citations

Characterization of Tumorigenic and Metastatic Properties of Murine Sarcoma Virus-Transformed Nonproducer Balb/3T3 Cell Lines<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1980 • 13 citations

Relationship between concanavalin A-induced agglutinability of murine leukemia cells and their propensity to form heterotypic aggregates with syngeneic lymphoid cells.

1981 • 13 citations

Comparative Oncology: The Veterinary Contribution

1976 • 12 citations

In vitro clonogenicity of primary human tumor cells: quantitation and relationship to tumor stem cells.

1980 • 12 citations

Metastasis Spread from Syngeneic Murine Tumours

1978 • 12 citations

Arrest and Extravasation of Cancer Cells with Special Reference to Brain Metastases and the Microinjury Hypothesis

1980 • 11 citations

Organ-specific and systemic alloantigens: Interrelationships and biologic implications.

1980 • 11 citations

Lymphatic metastasis of tumour; persistent transport of cells

1979 • 7 citations

The pH-dependence of glucose transport inhibition by local anesthetics in human erythrocytes

1978 • 7 citations

Influence of location within a tumor on cell survival as measured by a clonogenic assay.

1981 • 7 citations

Studies on the role of cancer chemotherapy for prevention of lymph node metastasis.

1961 • 6 citations

Cancer chemotherapy screening with experimental tumors which metastasize to lymph nodes.

1970 • 6 citations

Methods for Morphological and Biochemical Analysis of Invasion in vitro

1980 • 6 citations

Differential Inhibition of In Vitro Malignant Cell Assays by B16 Mouse Melanoma Variants<xref ref-type="fn" rid="FN2">2</xref>

1980 • 5 citations

Malignancy and prognosis evaluated by an embryonic system

1978 • 4 citations

Contemporary Topics in Immunobiology: Vol. 7

1979 • 4 citations

Lymphatic System Metastasis

1981 • 3 citations

Cellular basis for regulation of tumor growth, p. 255-266. In isaac p. Witz and m. G. Hanna, jr. [eds.] Contemporary topics in immunobiology, vol. 10. New york, plenum publ.

1980 • 2 citations

In situ expression of tumor immunity. Contemporary topics in immunobiology, Vol. 10.

1981 • 2 citations

Localization of organ-specific alloantigens in the kidney.

1981 • 1 citations

Transplantation Today

1977 • 1 citations