Isoform-Selective Activation of Protein Kinase C by Nitric Oxide in the Heart of Conscious Rabbits

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Some statistical methods useful in circulation research.

1980 • 3,978 citations

Chelerythrine is a potent and specific inhibitor of protein kinase C

1990 • 1,208 citations

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

1993 • 1,005 citations

Nitric Oxide: Pathophysiological Mechanisms

1995 • 876 citations

Mitochondrial ATP-Dependent Potassium Channels

1998 • 825 citations

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

1996 • 730 citations

Complexes of ^.NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects

1991 • 724 citations

Nitric Oxide and Cardiac Function

1996 • 721 citations

Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia.

1993 • 629 citations

Preconditioning protects ischemic rabbit heart by protein kinase C activation

1994 • 603 citations

Role of Bradykinin in Protection of Ischemic Preconditioning in Rabbit Hearts

1995 • 524 citations

Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms ε and η in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity

1997 • 491 citations

Oxygen Radicals Released During Ischemic Preconditioning Contribute to Cardioprotection in the Rabbit Myocardium

1997 • 490 citations

Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C

1995 • 424 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

A Selective ε-Protein Kinase C Antagonist Inhibits Protection of Cardiac Myocytes from Hypoxia-induced Cell Death

1997 • 386 citations

Protein kinase C. Its role in ischemic preconditioning in the rat.

1994 • 362 citations

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

1993 • 352 citations

The Protective Effect of Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Mediated by Nitric Oxide Synthase

1997 • 316 citations

Evidence that Translocation of Protein Kinase C is a Key Event During Ischemic Preconditioning of Rabbit Myocardium

1994 • 310 citations

Atherosclerosis and the Two Faces of Endothelial Nitric Oxide Synthase

1998 • 298 citations

Oxygen Radicals Can Induce Preconditioning in Rabbit Hearts

1997 • 294 citations

Does Ischemic Preconditioning in the Human Involve Protein Kinase C and the ATP-Dependent K ⁺ Channel?

1995 • 293 citations

Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning.

1994 • 272 citations

alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.

1994 • 258 citations

Evidence That Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Triggered by the Generation of Nitric Oxide

1997 • 255 citations

Nitric Oxide Synthase Is the Mediator of Late Preconditioning Against Myocardial Infarction in Conscious Rabbits

1998 • 254 citations

Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs.

1996 • 244 citations

Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs.

1995 • 238 citations

A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.

1994 • 236 citations

<scp>l</scp> -Arginine Treatment Alters the Kinetics of Nitric Oxide and Superoxide Release and Reduces Ischemia/Reperfusion Injury in Skeletal Muscle

1997 • 236 citations

Nitric Oxide (NO) Donor Molecules

1995 • 221 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Nitric Oxide Donors Induce Late Preconditioning Against Myocardial Stunning and Infarction in Conscious Rabbits via an Antioxidant-Sensitive Mechanism

1998 • 210 citations

Effect of temperature on myocardial infarction in swine

1996 • 175 citations

Selective Activation of A ₃ Adenosine Receptors With N ⁶ -(3-Iodobenzyl)Adenosine-5′- N -Methyluronamide Protects Against Myocardial Stunning and Infarction Without Hemodynamic Changes in Conscious Rabbits

1997 • 171 citations

Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved.

1998 • 163 citations

Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium

1995 • 161 citations

Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor

1994 • 158 citations

Prevention of Ischemic Preconditioning Only by Combined Inhibition of Protein Kinase C and Protein Tyrosine Kinase in Pigs

1998 • 157 citations

Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits

1997 • 151 citations

Alpha 1-receptor-independent activation of protein kinase C in acute myocardial ischemia. Mechanisms for sensitization of the adenylyl cyclase system.

1992 • 144 citations

Cellular Mechanisms in Ischemic Preconditioning: The Role of Adenosine and Protein Kinase C a

1994 • 134 citations

Time Course of Late Preconditioning Against Myocardial Stunning in Conscious Pigs

1996 • 132 citations

Does Ischemic Preconditioning Trigger Translocation of Protein Kinase C in the Canine Model?

1995 • 122 citations

The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase: an overview

1996 • 122 citations

Postischemic myocardial "stunning". Identification of major differences between the open-chest and the conscious dog and evaluation of the oxygen radical hypothesis in the conscious dog.

1991 • 109 citations

Demonstration of free radical generation in the "stunned" myocardium in the conscious dog and identification of major differences between conscious and open-chest dogs.

1993 • 109 citations

Activation of ɛ protein kinase C correlates with a cardioprotective effect of regular ethanol consumption

1998 • 106 citations

Phospholipase D Plays a Role in Ischemic Preconditioning in Rabbit Heart

1996 • 97 citations

Epicardial Temperature is a Major Predictor of Myocardial Infarct Size in Dogs

1997 • 80 citations

Does protein kinase C play a role in ischemic preconditioning in rat hearts?

1995 • 79 citations

Anaesthetics alter the magnitude of infarct limitation by ischaemic preconditioning

1994 • 74 citations

The cellular basis of angiotensin converting enzyme mRNA expression in rat heart

1996 • 72 citations

Lack of tolerance to a 24-hour infusion of S-nitroso N-acetylpenicillamine (SNAP) in conscious rabbits.

1992 • 63 citations

Preconditioning of isolated rabbit cardiomyocytes: effects of glycolytic blockade, phorbol esters, and ischaemia

1994 • 61 citations

Role of adenosine receptors in late preconditioning against myocardial stunning in conscious rabbits

1997 • 60 citations

Translocation of PKC, Protein Phosphatase Inhibition and Preconditioning of Rabbit Cardiomyocytes

1996 • 51 citations

Nebulized nitric oxide/nucleophile adduct reduces chronic pulmonary hypertension.

1996 • 51 citations

Myocardial Adaptation, Stress Proteins, and the Second Window of Protection

1996 • 44 citations

Preconditioning During Ischemia

1995 • 37 citations

Premedication with the opioid analgesic butorphanol raises the threshold for ischemic preconditioning in dogs

1997 • 34 citations

Common methodological problems and artifacts associated with studies of myocardial stunning in vivo

1995 • 32 citations

Characterization of NK₃ receptors in rabbit isolated iris sphincter muscle

1997 • 31 citations

ANG II AT₁and AT₂receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cells

1997 • 30 citations

Direct evidence that ischemic preconditioning does not cause protein kinase C translocation in rabbit heart

1996 • 29 citations

PKC-lambda is the atypical protein kinase C isoform expressed by immature ventricle

1997 • 28 citations

Nebulized nitric oxide/nucleophile adduct reduces chronic pulmonary hypertension

1996 • 19 citations

Abstract

1997 • 16 citations

Baroreflex resetting but no vascular tolerance in response to transdermal glyceryl trinitrate in conscious rabbits

1996 • 4 citations

Two distinct mechanisms induce a subtype-selective activation of protein kinase C in acute myocardial ischemia

1996 • 2 citations