Nitroglycerin Induces Late Preconditioning Against Myocardial Infarction in Conscious Rabbits Despite Development of Nitrate Tolerance

ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction

1995 • 1,786 citations

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

1993 • 1,005 citations

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

1995 • 660 citations

Prevention and Reversal of Nitrate Tolerance in Patients with Congestive Heart Failure

1987 • 366 citations

The Protective Effect of Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Mediated by Nitric Oxide Synthase

1997 • 316 citations

The nitric oxide hypothesis of late preconditioning

1998 • 274 citations

Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts.

1989 • 267 citations

Isoform-Selective Activation of Protein Kinase C by Nitric Oxide in the Heart of Conscious Rabbits

1999 • 258 citations

Evidence That Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Triggered by the Generation of Nitric Oxide

1997 • 255 citations

Nitric Oxide Synthase Is the Mediator of Late Preconditioning Against Myocardial Infarction in Conscious Rabbits

1998 • 254 citations

Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs.

1995 • 238 citations

Characterisation of the infarct-limiting effect of delayed preconditioning: timecourse and dose-dependency studies in rabbit myocardium

1997 • 214 citations

Nitric Oxide Donors Induce Late Preconditioning Against Myocardial Stunning and Infarction in Conscious Rabbits via an Antioxidant-Sensitive Mechanism

1998 • 210 citations

Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.

1995 • 179 citations

Exogenous Nitric Oxide Can Trigger a Preconditioned State Through a Free Radical Mechanism, But Endogenous Nitric Oxide Is Not a Trigger of Classical Ischemic Preconditioning

2000 • 169 citations

Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits

1997 • 151 citations

Time Course of Late Preconditioning Against Myocardial Stunning in Conscious Pigs

1996 • 132 citations

Antianginal effects of intravenous nitroglycerin over 24 hours.

1988 • 129 citations

Tolerance to organic nitrates.

1986 • 126 citations

Postischemic myocardial "stunning". Identification of major differences between the open-chest and the conscious dog and evaluation of the oxygen radical hypothesis in the conscious dog.

1991 • 109 citations

Infarct limitation of the second window of protection in a conscious rabbit model

1996 • 108 citations

Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Vitamin E on Attenuation of the Development of Nitrate Tolerance

1997 • 95 citations

Epicardial Temperature is a Major Predictor of Myocardial Infarct Size in Dogs

1997 • 80 citations

Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway

1999 • 61 citations

Infarct limitation of the second window of protection in a conscious rabbit model

1996 • 54 citations

Norepinephrine-induced Sustained Myocardial Adaptation to Ischemia is Dependent onα1-Adrenoceptors and Protein Synthesis

1996 • 39 citations

Nitric oxide donors attenuate myocardial stunning in conscious rabbits

1999 • 36 citations

Hemodynamic and volumetric effects of venodilation with nitroglycerin in chronic mitral regurgitation

1987 • 35 citations

Potential problems with intermittent nitrate therapy.

1996 • 12 citations