TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

The microenvironment of the tumour–host interface

2001 • 2,307 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Putting tumours in context

2001 • 2,145 citations

TGF-β signaling: positive and negative effects on tumorigenesis

2002 • 830 citations

TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis

1998 • 630 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

2002 • 406 citations

Malignant MCF10CA1 Cell Lines Derived from Premalignant Human Breast Epithelial MCF10AT Cells

2001 • 391 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 326 citations

Elevated Plasma Transforming Growth Factor-β1 Levels in Breast Cancer Patients Decrease After Surgical Removal of the Tumor

1995 • 207 citations

Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast

1992 • 154 citations

Transforming Growth Factor-β and Breast Cancer Risk in Women With Mammary Epithelial Hyperplasia

1999 • 134 citations

Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

1998 • 123 citations

Loss of expression of transforming growth factor beta type II receptor correlates with high tumour grade in human breast in‐situ and invasive carcinomas

2000 • 118 citations

Rapamycin Potentiates Transforming Growth Factor β-Induced Growth Arrest in Nontransformed, Oncogene-Transformed, and Human Cancer Cells

2002 • 103 citations

Conditional loss of TGF‐β signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice

2002 • 81 citations

Hepatocellular expression of a dominant-negative mutant TGF-β type II receptor accelerates chemically induced hepatocarcinogenesis

2001 • 67 citations

The Role of Sp1 in the Differential Expression of Transforming Growth Factor-β Receptor Type II in Human Breast Adenocarcinoma MCF-7 Cells

2000 • 34 citations