Death before birth: clues from gene knockouts and mutations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

MyoD or Myf-5 is required for the formation of skeletal muscle

1993 • 1,663 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

Genetic variants and strains of the laboratory mouse

1990 • 1,519 citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1994 • 1,412 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 • 1,279 citations

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

1991 • 1,074 citations

Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning

1994 • 1,010 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

WHOLE‐EMBRYO CULTURE AND THE STUDY OF MAMMALIAN EMBRYOS DURING ORGANOGENESIS

1978 • 895 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Wnt-3a regulates somite and tailbud formation in the mouse embryo.

1994 • 784 citations

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1994 • 777 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

1994 • 632 citations

The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development

1994 • 616 citations

Essential role of Mash-2 in extraembryonic development

1994 • 612 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

Experimental Approaches to Mammalian Embryonic Development

1987 • 596 citations

Mice develop normally without tenascin.

1992 • 590 citations

The T-locus of the mouse

1975 • 567 citations

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.

1994 • 550 citations

c-Jun is essential for normal mouse development and hepatogenesis

1993 • 543 citations

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.

1993 • 536 citations

Early embryonic mortality in women

1982 • 512 citations

Genetic variants and strains of the Laboratory mouse

1996 • 500 citations

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

1993 • 394 citations

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.

1993 • 393 citations

[POSTRAUMATIC PHLEBOTHROMBOTIC DISEASE OF THE LOWER EXTREMITIES].

1964 • 368 citations

The embryonic development of mammalian neural tube defects

1990 • 337 citations

Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development.

1994 • 336 citations

Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice.

1994 • 325 citations

Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.

1992 • 314 citations

Development of the short‐tailed mutant in the house mouse

1935 • 305 citations

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse

1985 • 294 citations

Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death

1984 • 285 citations

Mid-gestational lethality in mice lacking keratin 8.

1993 • 247 citations

Maternal and embryonic factors associated with prenatal loss in mammals

1986 • 245 citations

Formation of genetically mosaic mouse embryos, and early development of “lethal (t¹²/t¹²)–normal” mosaics

1964 • 205 citations

Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus

1993 • 193 citations

Persistent truncus arteriosus in the Splotch mutant mouse

1989 • 184 citations

Chromosome abnormalities in human embryos after in vitro fertilization

1983 • 183 citations

The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein.

1993 • 171 citations

A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration

1991 • 147 citations

A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras

1991 • 117 citations

The effects of a lethal mutation responsible for duplications and twinning in mouse embryos

1949 • 112 citations

The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene.

1994 • 111 citations

Congenital malformations of the central nervous system in spontaneous abortions.

1976 • 109 citations

STEEL, A NEW DOMINANT GENE IN THE HOUSE MOUSE

1956 • 102 citations

Frequency of chromosomal abnormalities in miscarriages and perinatal deaths.

1977 • 99 citations

Insertional mutagenesis in mice

1987 • 99 citations

A murine homolog of the yeast RNA1 gene is required for postimplantation development.

1994 • 95 citations

Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus.

1994 • 92 citations

Spontaneous aortic aneurysms in blotchy mice.

1975 • 90 citations

A SEX-LINKED DEFECT IN THE CROSS-LINKING OF COLLAGEN AND ELASTIN ASSOCIATED WITH THE MOTTLED LOCUS IN MICE

1974 • 86 citations

THE MORPHOLOGICAL MANIFESTATIONS OF A DOMINANT MUTATION IN MICE AFFECTING TAIL AND UROGENITAL SYSTEM

1943 • 78 citations

Cytokines Determining the Success or Failure of Pregnancy

1991 • 78 citations

legless insertional mutation: morphological, molecular, and genetic characterization.

1991 • 70 citations

The DDK inbred strain as a model for the study of interactions between parental genomes and egg cytoplasm in mouse preimplantation development

1990 • 69 citations

Oligosyndactyly: A lethal mutation in the mouse that results in mitotic arrest very early in development

1984 • 67 citations

Reduced gap junctional communication is associated with the lethal condition characteristic of DDK mouse eggs fertilized by foreign sperm

1987 • 57 citations

Fine structural study of cell migration in the early mesoderm of normal and mutant mouse embryos (T-locus: t9/t9)

1974 • 53 citations

New Challenges in Human in Vitro Fertilization

1993 • 46 citations

In vitro studies of mouse embryos bearing mutations at the T locus: tw5 and t12

1976 • 43 citations

Knobbly, a new dominant mutation in the mouse that affects embryonic ectoderm organization

1984 • 40 citations

Mouse albino‐deletions: From genetics to genes in development

1992 • 40 citations

Death of mouse embryos that lack a functional gene for glucose phosphate isomerase

1990 • 34 citations

Developmental analysis of lethal effects of homozygosity for the C25H deletion in the mouse

1978 • 31 citations

The developmental analysis of an embryonic lethal (c6H) in the mouse

1976 • 27 citations

Effects of the lethal yellow (AY) mutation in mouse aggregation chimeras

1990 • 20 citations

Embryological study of aT/tlocus mutation (tw73) affecting trophectoderm development

1976 • 19 citations

In vivo and in vitro studies on the early embryonic lethal tail‐short (Ts) in the mouse

1980 • 18 citations

Investigation of the tissue specificity of the lethal yellow (A^y) gene in mouse embryos

1988 • 13 citations

Embryological effects of a minute deficiency in linkage group II of the mouse

1972 • 10 citations

Morula decompaction (mdn), a Preimplantation Recessive Lethal Defect in a Transgenic Mouse Line

1993 • 9 citations

Developmental studies of the lethal gene Bld in the mouse. I. Post-implantation development of the lethal homozygote.

1979 • 8 citations

In vivo and in vitro development of mouse embryos homozygous for the embryonic lethal velvet coat (Ve) mutation

1981 • 3 citations

TWO NON-ALLELIG MUTANTS RESEMBLING “W” IN THE HOUSE MOUSE

1953 • 3 citations