The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

C. elegans: des neurones et des gènes

2003 • 3,047 citations

The Nematode Caenorhabditis elegans

1988 • 2,868 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

1992 • 1,787 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

The Ets family of transcription factors

1993 • 848 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

Caenorhabditis elegans : modern biological analysis of an organism

1995 • 689 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

A trans-spliced leader sequence on actin mRNA in C. elegans

1987 • 639 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

The lin-12 locus specifies cell fates in caenorhabditis elegans

1983 • 598 citations

Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans

1980 • 567 citations

The pathway to signal achievement

1993 • 563 citations

IDENTIFICATION AND CHARACTERIZATION OF 22 GENES THAT AFFECT THE VULVAL CELL LINEAGES OF THE NEMATODE CAENORHABDITIS ELEGANS

1985 • 531 citations

Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans

1981 • 494 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

ISOLATION AND GENETIC CHARACTERIZATION OF CELL-LINEAGE MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1980 • 413 citations

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

1990 • 412 citations

Pattern formation during vulval development in C. elegans

1986 • 411 citations

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

1990 • 397 citations

The gene lin-3 encodes an inductive signal for vulval development in C. elegans

1992 • 392 citations

A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans

1987 • 333 citations

Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway

1995 • 327 citations

A sequence assembly and editing program for efficient management of large projects

1991 • 322 citations

The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

1994 • 315 citations

daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

1990 • 293 citations

Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans

1995 • 292 citations

The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch

1988 • 281 citations

A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant

1987 • 280 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

1993 • 276 citations

Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans

1981 • 270 citations

The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.

1989 • 259 citations

Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

1992 • 258 citations

The basal component of the nematode dense-body is vinculin

1989 • 254 citations

The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.

1994 • 254 citations

The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans

1989 • 249 citations

Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

1988 • 248 citations

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

1991 • 246 citations

Cell autonomy of lin-12 function in a cell fate decision in C. elegans

1989 • 241 citations

The Ets transcription factors encoded by the Drosophila gene pointed direct glial cell differentiation in the embryonic CNS

1994 • 235 citations

The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.

1994 • 228 citations

Lateral inhibition during vulval induction in Caenorhabditis elegans

1988 • 218 citations

Net, a new ets transcription factor that is activated by Ras.

1994 • 216 citations

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

1994 • 212 citations

Transcript analysis of glp-1 and lin-12, homologous genes required for cell interactions during development of C. elegans

1989 • 201 citations

Different Levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates

1995 • 200 citations

Gene regulation by Ets proteins

1993 • 199 citations

Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis

1990 • 198 citations

The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.

1990 • 192 citations

Trans-splicing and polycistronic transcription in Caenohabditis elegans

1995 • 181 citations

Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.

1991 • 170 citations

lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.

1993 • 167 citations

PEST sequences are signals for rapid intracellular proteolysis.

1990 • 166 citations

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.

1994 • 158 citations

Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans

1990 • 157 citations

Integration of signaling information in controlling cell-fate decisions in Dictyostelium.

1995 • 149 citations

Cell interactions coordinate the development of the C. elegans egg-laying system

1990 • 136 citations

Sequential signalling during Caenorhabditis elegans vulval induction

1995 • 130 citations

The ets gene family

1992 • 107 citations

MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.

1995 • 107 citations

Genetics of signal transduction in invertebrates

1994 • 96 citations

The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors.

1992 • 96 citations

The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.

1995 • 95 citations

Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans

1995 • 88 citations

Signal transduction during C. elegans vulval induction

1991 • 75 citations

Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans

1991 • 66 citations

A divergent ets-related protein, elk-1, recognizes similar c-ets-1 proto-oncogene target sequences and acts as a transcriptional activator.

1992 • 62 citations

The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors.

1990 • 62 citations

lin-25, a gene required for vulval induction in Caenorhabditis elegans.

1995 • 61 citations

pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.

1992 • 61 citations

A perfect vulva every time: Gradients and signaling cascades in C. elegans

1995 • 58 citations

Regulation of the dorsal morphogen by the Toll and torso signaling pathways: a receptor tyrosine kinase selectively masks transcriptional repression.

1994 • 57 citations

Signal transduction and cell fate specification during Caenorhabditis elegans vulval development

1994 • 51 citations

Tyrosine kinases and their interactions with signalling proteins

1992 • 51 citations

Chapter 7 Genetic Balancers

1995 • 34 citations

A selective λ phage cloning vector with automatic excision of the insert in a plasmid

1992 • 12 citations

Genetic and molecular analysis of let-60 ras, lin-1 and lin-9 : genes that function in C. elegans vulval induction

1994 • 4 citations

Hydro, azo, azoxy

1976 • 2 citations

jockey leads by a short head

1992 • 2 citations