Stromelysin in tumor progression and metastasis

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

Textbook of Rheumatology.

1988 • 593 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

1984 • 550 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

1986 • 515 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

The Approaching Era of the Tumor Suppressor Genes

1987 • 468 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.

1985 • 450 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

Active-site zinc ligands and activated H2O of zinc enzymes.

1990 • 432 citations

Introduction of a Normal Human Chromosome 11 into a Wilms' Tumor Cell Line Controls Its Tumorigenic Expression

1987 • 407 citations

Transforming growth factors and the regulation of cell proliferation

1990 • 390 citations

The collagenase gene family in humans consists of at least four members

1988 • 364 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.

1985 • 344 citations

Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.

1987 • 323 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

Growth Factors Regulate Transin Gene Expression by c- fos -Dependent and c- fos -Independent Pathways

1988 • 290 citations

Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development.

1989 • 284 citations

Molecular characterization and expression of the gene encoding human erythroid-potentiating activity

1985 • 279 citations

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

1988 • 275 citations

Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7

1990 • 270 citations

Identification of Germline and Somatic Mutations Affecting the Retinoblastoma Gene

1988 • 270 citations

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

1986 • 260 citations

Inhibition of Collagenolytic Activity and Metastasis of Tumor Cells by a Recombinant Human Tissue Inhibitor of Metalloproteinases

1990 • 233 citations

Human skin fibroblast collagenase inhibitor. Comparative studies in human connective tissues, serum, and amniotic fluid.

1983 • 231 citations

Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components

1983 • 222 citations

Purification and properties of a small latent matrix metalloproteinase of the rat uterus.

1988 • 220 citations

Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. Stimulation by 12-O-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenase.

1985 • 220 citations

8 Growth Factor-Regulated Proteases and Extracellular Matrix Remodeling during Mammalian Development

1990 • 219 citations

An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

1986 • 218 citations

Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.

1987 • 217 citations

Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members

1989 • 212 citations

cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

1990 • 202 citations

The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis

1990 • 197 citations

Primary Rat Embryo Cells Transformed by One or Two Oncogenes Show Different Metastatic Potentials

1986 • 196 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts.

1988 • 183 citations

Epidermal Growth Factor Stimulation of Stromelysin mRNA in Rat Fibroblasts Requires Induction of Proto-Oncogenes c-fos and c-jun and Activation of Protein Kinase C

1990 • 170 citations

Structure-function relationships in the collagenase family member transin.

1988 • 169 citations

A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: evidence for inducible and constitutive transcripts

1986 • 155 citations

NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells

1989 • 140 citations

Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin. I. Excisional wound model.

1990 • 138 citations

Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes.

1987 • 129 citations

Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene

1987 • 127 citations

Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants.

1988 • 126 citations

Transcriptional regulation of two serum-induced RNAs in mouse fibroblasts: equivalence of one species to B2 repetitive elements.

1985 • 120 citations

Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C.

1990 • 112 citations

Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression

1988 • 112 citations

Transcriptional regulation of human stromelysin

1989 • 109 citations

Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts

1989 • 109 citations

Transforming growth factor beta 1 and cAMP inhibit transcription of epidermal growth factor- and oncogene-induced transin RNA.

1988 • 107 citations

Stromelysin/transin and tumor progression.

1990 • 104 citations

Mutational analysis of the transin (rat stromelysin) autoinhibitor region demonstrates a role for residues surrounding the “cysteine switch”

1991 • 99 citations

Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases

1989 • 97 citations

Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats.

1989 • 92 citations

Cloning of a complementary dna for rabbit proactivator. a metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase

1987 • 86 citations

Production of collagenase and inhibitor (TIMP) by intracranial tumors and dura in vitro

1983 • 75 citations

A fibrosarcoma model derived from mouse embryo cells: Growth properties and secretion of collagenase and metalloproteinase inhibitor (TIMP) by tumour cell lines

1984 • 74 citations

Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene

1988 • 59 citations

Transcriptional modulation of transin gene expression by epidermal growth factor and transforming growth factor beta.

1988 • 49 citations

Transcriptional Regulation of Two Serum-Induced RNAs in Mouse Fibroblasts: Equivalence of One Species to B2 Repetitive Elements

1985 • 46 citations

Presence of transcription regulatory elements within an intron of the virus-inducible murine TIMP gene.

1988 • 42 citations

Systemic administration of TIMP in the treatment of collagen-induced arthritis in mice

1989 • 42 citations

Tumor promoters induce a transient expression of tumor-associated genes in both basal and differentiated cells of the mouse epidermis

1988 • 41 citations

Activation of the cellular harvey ras gene in mouse skin tumors initiated with urethane

1989 • 27 citations

COMMENTARY: Chalones revisited—a possible role for transforming growth factor β in tumour promotion

1990 • 26 citations

Presence of Transcription Regulatory Elements within an Intron of the Virus-Inducible Murine TIMP Gene

1988 • 15 citations

Vegetation and Development of Llyn, a Welsh Mire

1971 • 14 citations

Transcriptional Modulation of Transin Gene Expression by Epidermal Growth Factor and Transforming Growth Factor Beta

1988 • 12 citations

Characterization of Metalloproteinases in Rat Gastric Tissues with Acetic Acid-Induced Ulcers

1989 • 9 citations