Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

mouse brain in stereotaxic coordinates

1997 • 3,077 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

Calbindin D-28k and parvalbumin in the rat nervous system

1990 • 2,068 citations

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 • 1,430 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

1997 • 1,313 citations

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1996 • 1,261 citations

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1998 • 1,207 citations

Unbiased Stereology: Three-Dimensional Measurement in Microscopy

1998 • 1,154 citations

Neurological anatomy in relation to clinical medicine

1982 • 1,013 citations

Unbiased Stereology. Three‐Dimensional Measurement in Microscopy.

1999 • 879 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1

1998 • 706 citations

Calcium-binding proteins: selective markers of nerve cells

1993 • 699 citations

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

1995 • 694 citations

Slowing of axonal transport is a very early event in the toxicity of ALS–linked SOD1 mutants to motor neurons

1999 • 621 citations

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.

1994 • 604 citations

Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1997 • 593 citations

ATLAS OF THE MOUSE BRAIN AND SPINAL CORD

1972 • 537 citations

Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons

1991 • 518 citations

Neurodegenerative Diseases

1994 • 492 citations

Calretinin in rat brain: An immunohistochemical study

1992 • 479 citations

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

1996 • 464 citations

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS)

1995 • 435 citations

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.

1996 • 397 citations

Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis.

1994 • 397 citations

The role of calcium‐binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis

1994 • 360 citations

Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones.

1993 • 348 citations

Neurofilaments and Orthograde Transport Are Reduced in Ventral Root Axons of Transgenic Mice that Express Human SOD1 with a G93A Mutation

1997 • 293 citations

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant

1997 • 287 citations

Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis

1995 • 266 citations

Estimation of the number of somatostatin neurons in the striatum: An in situ hybridization study using the optical fractionator method

1996 • 259 citations

Increased 3‐nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation

1997 • 248 citations

Glutamate Potentiates the Toxicity of Mutant Cu/Zn-Superoxide Dismutase in Motor Neurons by Postsynaptic Calcium-Dependent Mechanisms

1998 • 235 citations

Familial Amyotrophic Lateral Sclerosis

1967 • 235 citations

The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease.

1996 • 224 citations

A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase ( SOD1 ) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis

1997 • 189 citations

Stable transfection of calbindin-D28k into the GH3 cell line alters calcium currents and intracellular calcium homeostasis

1992 • 187 citations

Neurological Anatomy in Relation to Clinical Medicine (3rd Ed.)

1982 • 184 citations

A comparative study of the calcium-binding proteins calbindin-D28K, calretinin, calmodulin and parvalbumin in the rat spinal cord

1994 • 183 citations

CHANGES IN SIZES OF CORTICAL AND LOWER MOTOR NEURONS IN AMYOTROPHIC LATERAL SCLEROSIS

1991 • 173 citations

The rotator

1993 • 156 citations

Hypoglossal, trigeminal, and facial motoneuron involvement in amyotrophic lateral sclerosis

1988 • 149 citations

Intracellular Calcium Parallels Motoneuron Degeneration in SOD-1 Mutant Mice

1998 • 136 citations

Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions

1997 • 121 citations

The hypoglossal complex of vertebrates

1940 • 118 citations

Brainstem motoneuron pools that are selectively resistant in amyotrophic lateral sclerosis are preferentially enriched in parvalbumin: Evidence from monkey brainstem for a calcium-mediated mechanism in sporadic ALS

1995 • 114 citations

Endogenous calcium buffering in motoneurones of the nucleus hypoglossus from mouse

1998 • 108 citations

Parvalbumin is a marker of ALS-resistant motor neurons

1995 • 103 citations

Characterization of three yeast copper-zinc superoxide dismutase mutants analogous to those coded for in familial amyotrophic lateral sclerosis.

1994 • 98 citations

Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice

1998 • 98 citations

Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity.

1996 • 91 citations

Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: Neurochemical correlates of selective vulnerability

1996 • 90 citations

Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration

1999 • 89 citations

The distribution of hypoglossal motoneurons in the dog, rabbit and rat

1988 • 81 citations

Ocular motor function in motor neuron disease

1992 • 78 citations

Eye Movements in Amyotrophic Lateral Sclerosis

1982 • 76 citations

Oculomotor nuclear pathology in amyotrophic lateral sclerosis

1993 • 76 citations

Analysis of the functional effects of a mutation in SOD1 associated with familial amyotrophic lateral sclerosis

1994 • 70 citations

Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

1992 • 69 citations

Amyotrophic Lateral Sclerosis With Ophthalmoplegia

1979 • 63 citations

Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease

1996 • 62 citations

Light and electron microscopic distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic mice

1998 • 58 citations

Single-Cell RT-PCR and Functional Characterization of Ca²⁺Channels in Motoneurons of the Rat Facial Nucleus

1998 • 57 citations

Low expression of GluR2 AMPA receptor subunit protein by human motor neurons

1999 • 56 citations

Differential Abundance of Glutamate Transporter Subtypes in Amyotrophic Lateral Sclerosis (ALS)-Vulnerable versus ALS-Resistant Brain Stem Motor Cell Groups

1996 • 39 citations

Characterization of Wild‐Type and Amyotrophic Lateral Sclerosis‐Related Mutant Cu,Zn‐Superoxide Dismutases Overproduced in Baculovirus‐Infected Insect Cells

1995 • 35 citations

Cortical Neuropathology in Aging and Dementing Disorders

1999 • 35 citations

Oculomotor abnormalities in motor neuron disease

1993 • 32 citations

Superoxide dismutase and neurofilament transgenic models of amyotrophic lateral sclerosis

1998 • 27 citations

No difference between estimated mean nuclear volumes of various types of neurons in the mouse brain obtained on either isotropic uniform random sections or conventional frontal or sagittal sections

1999 • 23 citations

Differential vulnerability of autonomic and somatic motor neurons to N-methyl- d-aspartate-induced excitotoxicity

1998 • 18 citations