Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 • 1,015 citations

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1999 • 918 citations

Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment.

1996 • 756 citations

A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

2000 • 733 citations

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68

2000 • 683 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Microglial response to amyloid plaques in APPsw transgenic mice.

1998 • 580 citations

A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

1997 • 553 citations

Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

1998 • 549 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

1996 • 493 citations

Spontaneous alternation behavior.

1958 • 471 citations

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1999 • 355 citations

Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses

1997 • 351 citations

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

2001 • 346 citations

Evidence for glial-mediated inflammation in aged APPSW transgenic mice

1999 • 295 citations

A behavioural analysis of rats with damage to the medial prefrontal cortex using the morris water maze: evidence for behavioural flexibility, but not for impaired spatial navigation

1994 • 279 citations

REVIEWThe Gene Defects Responsible for Familial Alzheimer's Disease

1996 • 262 citations

Age-Related Amyloid β Deposition in Transgenic Mice Overexpressing Both Alzheimer Mutant Presenilin 1 and Amyloid β Precursor Protein Swedish Mutant Is Not Associated with Global Neuronal Loss

2000 • 227 citations

Progressive and gender-dependent cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease

1999 • 221 citations

Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice

2001 • 199 citations

Induction of cytokines in glial cells surrounding cortical β‐amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology

2000 • 198 citations

Behavioral disturbances in transgenic mice overexpressing the V717F Β-amyloid precursor protein.

1999 • 185 citations

Genetics and molecular advances in Alzheimer's disease

1993 • 183 citations

Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease

1999 • 154 citations

Behavioral disturbances in transgenic mice overexpressing the V717F Β-amyloid precursor protein.

1999 • 149 citations

Stress-induced disturbances in Morris water-maze performance: Interstrain variability

1995 • 147 citations

Neuroanatomical Abnormalities in Behaviorally Characterized APPV717F Transgenic Mice

2000 • 134 citations

Inheritance of spatial learning ability in inbred mice: A classical genetic analysis.

1989 • 121 citations

Spontaneous Alternation Behavior

1989 • 117 citations

Inheritance of spatial learning ability in inbred mice: A classical genetic analysis.

1989 • 102 citations

Nicotine enhances the learning and memory of aged rats

1995 • 91 citations

Genetic variation, hippocampal mossy fibres distribution, novelty reactions and spatial representation in mice

1990 • 85 citations

Blind rats are not profoundly impaired in the reference memory Morris water maze and cannot be clearly discriminated from rats with cognitive deficits in the cued platform task

1997 • 82 citations

Radial maze performance and open-field behaviours in aged C57BL/6 mice: Further evidence for preserved cognitive abilities during senescence

1994 • 45 citations

Alzheimer's Disease Families with Amyloid Precursor Protein Mutations^a

1993 • 43 citations

Septal Lesions Impair the Acquisition of a Cued Place Navigation Task: Attentional or Memory Deficit?

1998 • 40 citations

Behavioral deficits in APPV717F transgenic mice decient for the apolipoprotein E gene

2000 • 33 citations

Spontaneous Alternation Behavior and the Brain

1989 • 32 citations

Characterization of learning and memory behaviors and the effects of metrifonate in the C57BL strain of mice

1999 • 14 citations