Cyclooxygenase-2 Promotes Amyloid Plaque Deposition in a Mouse Model of Alzheimer's Disease Neuropathology

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

2001 • 1,382 citations

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease

1996 • 1,371 citations

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

2001 • 1,183 citations

Risk of Alzheimer's disease and duration of NSAID use

1997 • 1,113 citations

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 • 1,015 citations

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

1998 • 455 citations

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

1994 • 321 citations

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor

1994 • 317 citations

Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer’s disease

2000 • 282 citations

Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease

1999 • 243 citations

Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs

1999 • 237 citations

Potentiation of Excitotoxicity in Transgenic Mice Overexpressing Neuronal Cyclooxygenase-2

1999 • 220 citations

Neuronal Cyclooxygenase 2 Expression in the Hippocampal Formation as a Function of the Clinical Progression of Alzheimer Disease

2001 • 200 citations

Cytokine Gene Expression as a Function of the Clinical Progression of Alzheimer Disease Dementia

2000 • 192 citations

Induction of cyclo-oxygenase 2 in brains of patients with Downʼs syndrome and dementia of Alzheimer type

1997 • 152 citations

Profiling of amyloid beta peptide variants using SELDI Protein Chip arrays.

1999 • 120 citations

Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's Disease neuropathology

2002 • 105 citations

Cyclooxygenases in the Central Nervous System: Implications for Treatment of Neurological Disorders

2000 • 93 citations

Prostaglandin E₂Stimulates Amyloid Precursor Protein Gene Expression: Inhibition by Immunosuppressants

1999 • 86 citations

Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2

2002 • 29 citations