CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Effector and memory T-cell differentiation: implications for vaccine development

2002 • 1,757 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Similarities and differences in CD4+ and CD8+ effector and memory T cell generation

2003 • 865 citations

T CELL MEMORY

1998 • 863 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

CD27 is required for generation and long-term maintenance of T cell immunity

2000 • 726 citations

CD8+ T Cell Effector Mechanisms in Resistance to Infection

2000 • 725 citations

Virus-Specific CD8+ T Cells in Primary and Secondary Influenza Pneumonia

1998 • 685 citations

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

2001 • 600 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

In Vivo Activation of Antigen-Specific CD4 T Cells

2001 • 498 citations

CD8 T Cell Responses to Infectious Pathogens

2003 • 433 citations

Effector CD4⁺ and CD8⁺ T‐cell mechanisms in the control of respiratory virus infections

1997 • 430 citations

Activated Antigen-Specific CD8+ T Cells Persist in the Lungs Following Recovery from Respiratory Virus Infections

2001 • 403 citations

Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses

2002 • 402 citations

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 • 381 citations

Differentiation of Naive CTL to Effector and Memory CTL: Correlation of Effector Function with Phenotype and Cell Division

1998 • 379 citations

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

1991 • 372 citations

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1994 • 347 citations

Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells.

1990 • 340 citations

CD4 Effector T Cell Subsets in the Response to Influenza

2002 • 328 citations

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice.

1996 • 276 citations

Dynamics and Requirements of T Cell Clonal Expansion In Vivo at the Single-Cell Level: Effector Function Is Linked to Proliferative Capacity

1999 • 253 citations

MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL.

1997 • 207 citations

Differentiating between Memory and Effector Cd8 T Cells by Altered Expression of Cell Surface O-Glycans

2000 • 207 citations

Diversity of Epitope and Cytokine Profiles for Primary and Secondary Influenza A Virus-Specific CD8+ T Cell Responses

2001 • 207 citations

Immune interferon release when a cloned cytotoxic T-cell line meets its correct influenza-infected target cell

1982 • 202 citations

Migration Kinetics and Final Destination of Type 1 and Type 2 CD8 Effector Cells Predict Protection against Pulmonary Virus Infection

1999 • 195 citations

Naive, Effector, and Memory CD8 T Cells in Protection Against Pulmonary Influenza Virus Infection: Homing Properties Rather Than Initial Frequencies Are Crucial

1999 • 178 citations

Mechanism of Protective Immunity Against Influenza Virus Infection in Mice Without Antibodies

1998 • 173 citations

Clearance of an Influenza A Virus by CD4⁺T Cells Is Inefficient in the Absence of B Cells

1998 • 169 citations

Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation

2000 • 161 citations

Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8⁺T cells in influenza virus-infected mice

2003 • 150 citations

Preferential Accumulation of Antigen-specific Effector CD4 T Cells at an Antigen Injection Site Involves CD62E-dependent Migration but Not Local Proliferation

2003 • 148 citations

In vivoproliferation of naïve and memory influenza-specific CD8⁺T cells

1999 • 146 citations

Induction and Visualization of Mucosal Memory CD8 T Cells Following Systemic Virus Infection

1999 • 143 citations

Tumor-Specific Tc1, But Not Tc2, Cells Deliver Protective Antitumor Immunity

2001 • 136 citations

Uncoupling of Proliferative Potential and Gain of Effector Function by CD8+ T Cells Responding to Self-Antigens

2002 • 131 citations

Ly-6C is a marker of memory CD8+ T cells.

1995 • 109 citations

A Critical Role for OX40 in T Cell–mediated Immunopathology during Lung Viral Infection

2003 • 108 citations

Cytotoxic T lymphocytes produce immune interferon in response to antigen or mitogen.

1982 • 107 citations

Influence of effector molecules on the CD8+ T cell response to infection

2002 • 103 citations

Lymphotoxin-α-Deficient Mice Make Delayed, But Effective, T and B Cell Responses to Influenza

2002 • 103 citations

Activation and migration of CD8 T cells in the intestinal mucosa.

1997 • 102 citations

Cutting Edge: Virus-Specific CD4+ Memory T Cells in Nonlymphoid Tissues Express a Highly Activated Phenotype

2002 • 92 citations

CD4+T Cells Are Ineffective in Clearing a Pulmonary Infection with Influenza Type A Virus in the Absence of B Cells

1997 • 87 citations

Systemic T cell expansion during localized viral infection

1999 • 87 citations

Ly-6C regulates endothelial adhesion and homing of CD8⁺T cells by activating integrin-dependent adhesion pathways

1997 • 81 citations

Distinct Thresholds for CD8 T Cell Activation Lead to Functional Heterogeneity: CD8 T Cell Priming Can Occur Independently of Cell Division

2003 • 53 citations

HLA class I and II molecules present influenza virus antigens with different kinetics

1992 • 6 citations