Beta-amyloid peptide blocks the fast-inactivating K+ current in rat hippocampal neurons

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

1993 • 549 citations

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

1987 • 475 citations

Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis.

1995 • 418 citations

Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF

1993 • 383 citations

Translational termination efficiency in mammals is influenced by the base following the stop codon.

1995 • 283 citations

Solvent effects on self-assembly of beta-amyloid peptide

1995 • 271 citations

Purification and Characterization of Three Inhibitors of Voltage-Dependent K+ Channels from Leiurus Quinquestriatus var. Hebraeus Venom

1994 • 260 citations

Dependence of an adenosine-activated potassium current on a GTP-binding protein in mammalian central neurons

1987 • 254 citations

Beta-2 microglobulin is an amyloidogenic protein in man.

1985 • 245 citations

Fibril formation by primate, rodent, and Dutch-hemorrhagic analogs of Alzheimer amyloid .beta.-protein

1992 • 244 citations

Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors.

1986 • 221 citations

Rapid Communication: Ca²⁺ Channel Blockers Attenuate β‐Amyloid Peptide Toxicity to Cortical Neurons in Culture

1994 • 214 citations

Interaction of charybdotoxin with permeant ions inside the pore of a K+ channel

1992 • 175 citations

Soluble β-Amyloid Induction of Alzheimer's Phenotype for Human Fibroblast K ⁺ Channels

1994 • 168 citations

Ten to fourteen residue peptides of Alzheimer's disease protein are sufficient for amyloid fibril formation and its characteristic xray diffraction pattern

1987 • 154 citations

Selective up-regulation of an nmda receptor subunit mrna in cultured cerebellar granule cells by K+-induced depolarization and nmda treatment

1994 • 153 citations

Slow and fast transient potassium currents in cultured rat hippocampal cells.

1992 • 138 citations

A model for dendritic Ca2+ accumulation in hippocampal pyramidal neurons based on fluorescence imaging measurements

1994 • 129 citations

The Ca²⁺ influx induced by β‐amyloid peptide 25–35 in cultured hippocampal neurons results from network excitation

1995 • 123 citations

Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer's Disease Amyloid‐β Neurotoxicity

1993 • 122 citations

Anticonvulsants attenuate amyloid β-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology

1995 • 113 citations

β-Amyloid neurotoxicity: A discussion of in vitro findings

1992 • 113 citations

Crystal structure of α-dendrotoxin from the green mamba venom and its comparison with the structure of bovine pancreatic trypsin inhibitor

1992 • 101 citations

Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels.

1991 • 93 citations

Light scattering analysis of fibril growth from the amino-terminal fragment beta(1–28) of beta-amyloid peptide

1993 • 91 citations

Determination of the three-dimensional structure of iberiotoxin in solution by proton nuclear magnetic resonance spectroscopy

1992 • 90 citations

Amyloid β peptides act directly on single neurons

1993 • 84 citations

β‐Amyloid Neurotoxicity in Human Cortical Culture Is Not Mediated by Excitotoxins

1993 • 82 citations

Calcium‐Mediated Processes in Neuronal Degeneration^a

1994 • 72 citations

Elevated Intracellular Calcium Blocks Programmed Neuronal Death

1994 • 45 citations

Neurotoxicity of Aβ amyloid protein in vitro is not altered by calcium channel blockade

1995 • 41 citations

Similarities between β Amyloid Peptides 1-40 and 40-1: Effects on Aggregation, Toxicity in Vitro, and Injection in Young and Aged Rats

1994 • 40 citations

Cloning and functional expression of dendrotoxin K from black mamba, a potassium channel blocker

1993 • 39 citations

Aggregation State-Dependent Binding of β-Amyloid Peptide to Protein and Lipid Components of Rat Cortical Homogenates

1995 • 32 citations

Hippocampal damage produced in rats by α-dendrotoxin—a selective K+ channel blocker—involves non-NMDA receptor activation

1994 • 18 citations