Repression of Interleukin-2 mRNA Translation in Primary Human Breast Carcinoma Tumor-Infiltrating Lymphocytes

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

1993 • 2,807 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation.

1993 • 628 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

Impaired in Vitro Lymphocyte Transformation in Hodgkin's Disease

1965 • 379 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma.

1993 • 344 citations

Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway.

1991 • 344 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes.

1986 • 319 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

Delayed hypersensitivity in Hodgkin's disease

1972 • 244 citations

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1994 • 211 citations

The Human Interleukin-2 Receptor

1986 • 209 citations

Alterations in T cell receptor and signal transduction molecules in melanoma patients.

1995 • 192 citations

Direct activation of human resting T cells by IL 2: the role of an IL 2 receptor distinct from the Tac protein.

1987 • 179 citations

T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors.

1993 • 158 citations

T cell receptor-mediated signaling is defective in T cells obtained from patients with primary intracranial tumors.

1997 • 139 citations

Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45R0 (UCHL1)

1989 • 138 citations

The immunopathology of sequential tumor biopsies in patients treated with interleukin-2. Correlation of response with T-cell infiltration and HLA-DR expression.

1987 • 129 citations

Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor.

1992 • 117 citations

Studies on the Biosynthesis of Microsomal Membrane Proteins

1982 • 114 citations

Decreased Synthesis of Interleukin-2 (IL-2) in Insulin-dependent Diabetes Mellitus

1984 • 113 citations

Expression of cytokine genes or proteins and signaling molecules in lymphocytes associated with human ovarian carcinoma

1996 • 99 citations

In situ cytokine production by breast cancer tumor-infiltrating lymphocytes

1996 • 97 citations

Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signaling: role of soluble products from human renal cell carcinomas.

1997 • 84 citations

Expression of mRNA for cytokines in tumor‐infiltrating mononuclear cells in ovarian adenocarcinoma and invasive breast cancer

1992 • 79 citations

T cells infiltrating non-Hodgkin's B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present.

1995 • 76 citations

Expression of interleukin 2 receptors on human carcinoma cell lines and tumor growth inhibition by interleukin 2

1994 • 67 citations

Anergy as a mechanism of peripheral T cell tolerance.

1996 • 62 citations

T cells from late tumor-bearing mice express normal levels of p56lck, p59fyn, ZAP-70, and CD3 zeta despite suppressed cytolytic activity.

1995 • 57 citations

Suppression of human peripheral blood lymphocytes by Fusobacterium nucleatum.

1984 • 54 citations

Lack of IL-2 cytokine expression despite Il-2 messenger RNA transcription in tumor-infiltrating lymphocytes in primary human breast carcinoma: selective expression of early activation markers.

1996 • 50 citations

T cell antigen receptor signal transduction pathways.

1996 • 49 citations

Constitutive production of IL-2 by human carcinoma cells, expression of IL-2 receptor, and tumor cell growth.

1995 • 47 citations

Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy.

1996 • 40 citations

Immunosuppressive factor derived from renal cancer cells

1989 • 7 citations

The expression and biological activity of IL-2 receptor on a human pancreas cancer cell line

1993 • 4 citations

Clinical studies on cell-mediated immunity in patients with renal cell carcinoma: interleukin-2 and interferon-γ production of lymphocytes

1992 • 4 citations