Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis through Caspase Activation

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

SAS System for Mixed Models

1996 • 10,609 citations

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

1996 • 3,496 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

1993 • 1,049 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

1995 • 885 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

Prevention of Apoptosis by a Baculovirus Gene During Infection of Insect Cells

1991 • 810 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Statistical Inference Based on Ranks

1986 • 641 citations

Regulation of apoptosis by viral gene products

1997 • 639 citations

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

1995 • 518 citations

Target Protease Specificity of the Viral Serpin CrmA

1997 • 517 citations

HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo

1998 • 506 citations

Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene

1993 • 495 citations

A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes.

1994 • 491 citations

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

1997 • 483 citations

Human cytomegalovirus IE1 and IE2 proteins block apoptosis

1995 • 471 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

Apoptosis: a mechanism of cell killing by influenza A and B viruses

1994 • 431 citations

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection

1995 • 411 citations

Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B

1995 • 382 citations

Dicing with death: dissecting the components of the apoptosis machinery

1994 • 363 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.

1994 • 352 citations

Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest

1997 • 348 citations

HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection

1998 • 332 citations

Programmed Cell Death in AIDS-Related HIV and SIV Infections

1993 • 316 citations

Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus

1991 • 304 citations

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr

1995 • 260 citations

Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control

1996 • 253 citations

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import

1996 • 253 citations

Identification of HIV-1 vpr product and function.

1990 • 251 citations

Progression to AIDS in the absence of a gene for vpr or vpx

1995 • 243 citations

HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor κB

1997 • 240 citations

Induction of cell differentiation by human immunodeficiency virus 1 vpr

1993 • 214 citations

The role of the Caspase family of cysteine proteases in apoptosis

1997 • 210 citations

Vpr-induced cell cycle arrest is conserved among primate lentiviruses

1996 • 192 citations

Mutational analysis of the human immunodeficiency virus vpr open reading frame

1989 • 183 citations

The fight of viruses against apoptosis

1998 • 177 citations

Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation

1995 • 176 citations

Vpr Stimulates Viral Expression and Induces Cell Killing in Human Immunodeficiency Virus Type 1-Infected Dividing Jurkat T Cells

1998 • 168 citations

Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease.

1994 • 152 citations

Human Immunodeficiency Virus Type 1 Vpr Is a Positive Regulator of Viral Transcription and Infectivity in Primary Human Macrophages

1998 • 140 citations

The HIV-1 vpr Protein Acts as a Negative Regulator of Apoptosis in a Human Lymphoblastoid T Cell Line: Possible Implications for the Pathogenesis of AIDS

1998 • 136 citations

A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles

1995 • 136 citations

Ultrastructural features of fetal erythroid precursors infected with parvovirus B19 in vitro: Evidence of cell death by apoptosis

1993 • 132 citations

Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells

1999 • 127 citations

Human isolates of dengue type 1 virus induce apoptosis in mouse neuroblastoma cells

1996 • 115 citations

Effect of human immunodeficiency virus type 1 protein R (vpr) gene expression on basic cellular function of fission yeast Schizosaccharomyces pombe

1996 • 111 citations

Suppression of apoptosis in insect cells stably transfected with baculovirus p35: dominant interference by N-terminal sequences p35(1-76)

1994 • 97 citations

Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair

1997 • 94 citations

Open reading frame vpr of simian immunodeficiency virus encodes a virion-associated protein

1990 • 94 citations

Baculovirus inhibitor of apoptosis functions at or upstream of the apoptotic suppressor P35 to prevent programmed cell death

1997 • 94 citations

The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication

1997 • 85 citations

Identification of Residues in the N-Terminal Acidic Domain of HIV-1 Vpr Essential for Virion Incorporation

1995 • 83 citations

An Inducible Human Immunodeficiency Virus Type 1 (HIV-1) Vector Which Effectively Suppresses HIV-1 Replication

1999 • 77 citations

In VitroandIn VivoTumor Growth Suppression by HIV-1 Vpr

1997 • 38 citations