A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

The Basic Science of Gene Therapy

1993 • 1,767 citations

Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells.

1993 • 1,395 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Human gene therapy comes of age

1992 • 927 citations

Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

1994 • 562 citations

Long-Term Improvement of Hypercholesterolemia After Ex Vivo Gene Therapy in LDLR-Deficient Rabbits

1991 • 369 citations

Adenovirus E1a proteins repress transcription from the SV40 early promoter

1985 • 366 citations

Cloning and structural analyses of hepatitis B virus DNAs, subtypeadr

1983 • 309 citations

In Vivo Gene Therapy of Hemophilia B: Sustained Partial Correction in Factor IX-Deficient Dogs

1993 • 305 citations

Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus

1991 • 304 citations

Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region.

1988 • 273 citations

Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes.

1992 • 248 citations

kat: a high-efficiency retroviral transduction system for primary human T lymphocytes

1994 • 225 citations

Mechanism of Cell Transformation by RNA Tumor Viruses

1971 • 214 citations

Internal initiation of translation in retroviral vectors carrying picornavirus 5' nontranslated regions

1991 • 201 citations

Transformation of mammalian cells by avian myelocytomatosis virus and avian erythroblastosis virus

1979 • 166 citations

Pseudotypes of Vesicular Stomatitis Virus with the Coat of Murine Leukaemia and of Avian Myeloblastosis Viruses

1972 • 136 citations

Factors affecting long-term stability of Moloney murine leukemia virus-based vectors

1989 • 135 citations

Cap-Independent Translation of Poliovirus mRNA is Conferred by Sequence Elements within the 5′ Noncoding Region

1988 • 129 citations

Transduction of primary human hepatocytes with amphotropic and xenotropic retroviral vectors.

1992 • 40 citations

Towards liver-directed gene therapy: Retrovirus-mediated gene transfer into human hepatocytes

1991 • 33 citations

Retroviruses: delivery vehicle to the liver

1993 • 24 citations

Long-term transgene expression from genetically modified hepatocytes grafted to the rat liver.

1992 • 10 citations