n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases

The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

1989 • 1,951 citations

Resolvins

2002 • 1,575 citations

Lipid mediator class switching during acute inflammation: signals in resolution

2001 • 1,355 citations

Effect of Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids on in Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function

1985 • 1,344 citations

Leukotrienes and Other Products of the 5-Lipoxygenase Pathway

1990 • 1,216 citations

Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

2000 • 1,136 citations

Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome

2003 • 1,069 citations

Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

2003 • 965 citations

The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil

1996 • 867 citations

Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression

2003 • 781 citations

Effect of an Enteric-Coated Fish-Oil Preparation on Relapses in Crohn's Disease

1996 • 780 citations

Polyunsaturated fatty acids, inflammation, and immunity

2001 • 765 citations

Enhanced Synthesis of Leukotriene B4 by Colonic Mucosa in Inflammatory Bowel Disease

1984 • 749 citations

Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

2001 • 733 citations

Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

2004 • 724 citations

Oral (n-3) Fatty Acid Supplementation Suppresses Cytokine Production and Lymphocyte Proliferation: Comparison between Young and Older Women

1991 • 704 citations

Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

2001 • 692 citations

Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion

2003 • 613 citations

Dietary fish oil and olive oil supplementation in patients with Rheumatoid Arthritis clinical and immunologic effects

1990 • 544 citations

Fish-Oil Fatty Acid Supplementation in Active Rheumatoid Arthritis

1987 • 544 citations

Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy

2003 • 527 citations

Psoriasis pathophysiology: current concepts of pathogenesis

2005 • 512 citations

n−3 Polyunsaturated fatty acids and inflammation: From molecular biology to the clinic

2003 • 507 citations

Dietary fat and asthma: is there a connection?

1997 • 503 citations

The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells.

1994 • 467 citations

Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan

1996 • 441 citations

EFFECTS OF MANIPULATION OF DIETARY FATTY ACIDS ON CLINICAL MANIFESTATIONS OF RHEUMATOID ARTHRITIS

1985 • 420 citations

Inflammatory mediators and islet ?-cell failure: a link between type 1 and type 2 diabetes

2003 • 416 citations

Dietary Supplementation with Fish Oil in Ulcerative Colitis

1992 • 405 citations

NF-κB inhibition by ω-3 fatty acids modulates LPS-stimulated macrophage TNF-α transcription

2003 • 397 citations

Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators

2003 • 392 citations

Eicosapentaenoic Acid Prevents LPS-Induced TNF-α Expression by Preventing NF-κB Activation

2004 • 391 citations

Consumption of oily fish and childhood asthma risk

1996 • 376 citations

In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis.

1992 • 353 citations

Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils.

1993 • 348 citations

Resolvins, docosatrienes, and neuroprotectins, novel omega‐3‐derived mediators, and their endogenous aspirin‐triggered epimers

2004 • 343 citations

Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects

2003 • 316 citations

n−3 Fatty acid supplements in rheumatoid arthritis

2000 • 314 citations

Encapsulated fish oil enriched in α‐tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions

2000 • 308 citations

Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial.

1992 • 306 citations

Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.

1984 • 304 citations

Polyunsaturated fatty acids and inflammation

2005 • 301 citations

Human neutrophil chemotactic and degranulating activities of leukotriene B5 (LTB5) derived from eicosapentaenoic acid

1983 • 291 citations

Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis

2003 • 287 citations

Influence of dietary supplementation with long‐chain n−3 or n−6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults

2001 • 284 citations

Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production

1997 • 271 citations

Supplementation of fish oil and olive oil in patients with rheumatoid arthritis

2005 • 263 citations

Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis

2002 • 257 citations

Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men

1999 • 255 citations

Fatty acid intake and Kupffer cell function: fish oil alters eicosanoid and monokine production to endotoxin stimulation.

1988 • 248 citations

Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study.

1992 • 247 citations

Dietary n-3 fatty acids and therapy for rheumatoid arthritis

1997 • 247 citations

Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans

2004 • 242 citations

Effects of high‐dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs clinical and immune correlates

1995 • 239 citations

Long‐term effect of omega‐3 fatty acid supplementation in active rheumatoid arthritis

1994 • 239 citations

Dietary Supplementation with γ-Linolenic Acid or Fish Oil Decreases T Lymphocyte Proliferation in Healthy Older Humans

2001 • 237 citations

Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis.

1988 • 234 citations

Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma

2000 • 232 citations

Effects of Dietary Lipid Manipulation upon Inflammatory Mediator Production by Murine Macrophages

1995 • 231 citations

Polyunsaturated fatty acids and inflammatory bowel disease

2000 • 231 citations

Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids

1995 • 231 citations

Fish Oil Decreases Macrophage Tumor Necrosis Factor Gene Transcription by Altering the NFκB Activity

1999 • 229 citations

Effect of low‐to‐moderate amounts of dietary fish oil on neutrophil lipid composition and function

2000 • 229 citations

Inhibition of tumour necrosis factor-α and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation

2003 • 228 citations

Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins

2005 • 221 citations

Omega-3 Fatty Acids and Low Carbohydrate Diet for Maintenance of Remission in Crohn's Disease: A Randomized Controlled Multicenter Trial

1996 • 218 citations

Dietary marine fatty acids (fish oil) for asthma in adults and children

2000 • 216 citations

Dietary fish oil modulates macrophage fatty acids and decreases arthritis susceptibility in mice.

1985 • 215 citations

The ability of fish oil to suppress tumor necrosis factor α production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor α production

2002 • 214 citations

Maternal fish oil supplementation in pregnancy reduces interleukin‐13 levels in cord blood of infants at high risk of atopy

2003 • 210 citations

Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis

1987 • 208 citations

Validation of a meta-analysis: The effects of fish oil in rheumatoid arthritis

1995 • 206 citations

Dietary n-3 polyunsaturated fatty acids prevent the development of atherosclerotic lesions in mice. Modulation of macrophage secretory activities.

1993 • 204 citations

Effect of dietary supplementation with fish oil lipids on mild asthma.

1988 • 202 citations

Supplementation with n‐3 fatty acids from fish oil in chronic inflammatory bowel disease—a randomized, placebo‐controlled, double‐blind cross‐over trial

1989 • 202 citations

Fish oil supplementation inhibits the expression of major histocompatibility complex class II molecules and adhesion molecules on human monocytes

1996 • 192 citations

Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children

1998 • 192 citations

Dietary fish oil reduces progression of chronic inflammatory lesions in a rat model of granulomatous colitis.

1990 • 188 citations

N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale?

2001 • 183 citations

Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects

2003 • 182 citations

Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation

2003 • 181 citations

Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis.

2000 • 179 citations

Eicosapentaenoic and docosahexaenoic acids alter rat spleen leukocyte fatty acid composition and prostaglandin E₂production but have different effects on lymphocyte functions and cell‐mediated immunity

1998 • 178 citations

Fatty acids as gatekeepers of immune cell regulation

2003 • 177 citations

Polyunsaturated fatty acids and rheumatoid arthritis

2001 • 176 citations

Lack of effect of foods enriched with plant- or marine-derived n−3 fatty acids on human immune function

2003 • 174 citations

Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human endothelial cell production of interleukin-6.

1997 • 173 citations

Effects of fish oil supplementation in rheumatoid arthritis.

1990 • 173 citations

The effects of short- and long-term supplementation with fish oil on the incorporation of n-3 polyunsaturated fatty acids into cells of the immune system in healthy volunteers.

1993 • 167 citations

Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acid

1986 • 166 citations

EFFECTS OF FISH OIL SUPPLEMENTATION ON NON-STEROIDAL ANTI—INFLAMMATORY DRUG REQUIREMENT IN PATIENTS WITH MILD RHEUMATOID ARTHRITIS—A DOUBLE-BLIND PLACEBO CONTROLLED STUDY

1993 • 164 citations

Allergy and asthma

2005 • 164 citations

The role of cytokines in the pathogenesis of rheumatoid arthritis.

1999 • 160 citations

n−3 Fatty acids, inflammation, and immunity— Relevance to postsurgical and critically III patients

2004 • 159 citations

Control of endothelial leukocyte adhesion molecules by fatty acids

1996 • 158 citations

Dietary n-3 fatty acid supplementation reduces superoxide production and chemiluminescence in a monocyte-enriched preparation of leukocytes

1990 • 154 citations

Diet, serum fatty acids, and atopic diseases in childhood

2001 • 151 citations

Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects

2003 • 150 citations

Arachidonic acid supplementation enhances synthesis of eicosanoids without suppressing immune functions in young healthy men

1998 • 146 citations

Effect of a Fish Oil Diet on Asthma: Results of a 1-Year Double-Blind Study

1991 • 139 citations

The Effects of Dietary Supplementation with Fish Oil Lipids on the Airways Response to Inhaled Allergen in Bronchial Asthma

1989 • 139 citations

The pivotal role of cytokines in muscle wasting during cancer

2005 • 138 citations

Treatment of Ulcerative Colitis with Fish Oil n-3-ω-Fatty Acid

1990 • 136 citations

Pro‐ and anti‐inflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year

1997 • 136 citations

The effects of dietary supplementation with n‐3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial

1992 • 133 citations

Inhibitory Effect of Fish Oil N-3 Polyunsaturated Fatty Acids on the Expression of Endothelial Cell Adhesion Molecules

1996 • 133 citations

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Other Anti- Inflammatory Agents in the Treatment of Neurodegenerative Disease

2005 • 133 citations

(n-3) Polyunsaturated Fatty Acids Modulate the Expression of Functionally Associated Molecules on Human Monocytes in Vitro

1996 • 131 citations

A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis

1993 • 130 citations

Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations

2000 • 129 citations

N-3 fatty acids only delay early relapse of ulcerative colitis in remission

1996 • 129 citations

The influence of different combinations of γ-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects

2004 • 127 citations

Effect of dietary fish oil supplementation on fever and cytokine production in human volunteers

1993 • 121 citations

Incorporation of fatty acids from fish oil and olive oil into colonic mucosal lipids and effects upon eicosanoid synthesis in inflammatory bowel disease.

1991 • 120 citations

Dietary Supplementation with co‐3‐Polyunsaturated Fatty Acids Decreases Mononuclear Cell Proliferation and Interleukin‐1β Content but not Monokine Secretion in Healthy and Insulin‐Dependent Diabetic Individuals

1991 • 119 citations

Decreased Interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids

1992 • 118 citations

Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions.

2000 • 117 citations

Effect of Six Months of Fish Oil Supplementation in Stable Rheumatoid Arthritis. A Double-blind, Controlled Study

1992 • 111 citations

Endothelial dysfunction, inflammation, and insulin resistance: A focus on subjects at risk for type 2 diabetes

2004 • 108 citations

Dietary fish oil reduces intercellular adhesion molecule 1 and scavenger receptor expression on murine macrophages

2000 • 108 citations

n-3 Fatty acids for the treatment of inflammatory bowel diseases

2002 • 107 citations

Atherosclerotic plaque rupture: emerging insights and opportunities

1999 • 106 citations

n-3 fatty acids and cysteinyl-leukotriene formation in humans in vitro, ex vivo, and in vivo.

1993 • 102 citations

Effect of eicosapentaenoic acid in asthma

1988 • 101 citations

Dietary Fish Oil Effects on Seasonal Hay Fever and Asthma in Pollen-sensitive Subjects

1993 • 100 citations

Endogenous Anti-inflammatory Mediators from Arachidonate in Human Neutrophils

2002 • 99 citations

Modulation of Lipopolysaccharide-Stimulated Macrophage Tumor Necrosis Factor-α Production by ω-3 Fatty Acid Is Associated with Differential Cyclooxygenase-2 Protein Expression and Is Independent of Interleukin-10

2002 • 99 citations

Therapeutic potential of fish oil in the treatment of ulcerative colitis

1989 • 97 citations

The modulatory effects of prostaglandin‐E on cytokine production by human peripheral blood mononuclear cells are independent of the prostaglandin subtype

2002 • 96 citations

Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects

2004 • 95 citations

Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumatoid arthritis.

1992 • 87 citations

Role of leukotrienes in asthma.

1994 • 87 citations

Vitamin e status during dietary fish oil supplementation in rheumatoid arthritis

1990 • 84 citations

Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease

2004 • 83 citations

Long-term supplementation with n-3 fatty acids, II: effect on neutrophil and monocyte chemotaxis

1992 • 82 citations

Cod liver oil inhibits neutrophil and monocyte chemotaxis in healthy males

1989 • 80 citations

Increased consumption of polyunsaturated oils may be a cause of increased prevalence of childhood asthma

1994 • 80 citations

Distal Procto-Colitis, Natural Cytotoxicity, and Essential Fatty Acids

1998 • 80 citations

The Eicosapentaenoic to Docosahexaenoic Acid Ratio of Diets Affects the Pathogenesis of Arthritis in Lew/SSN Rats

2000 • 77 citations

No effect of a very low dose of n-3 fatty acids on monocyte function in healthy humans

1996 • 76 citations

IN VITRO EFFECTS OF EICOSANOIDS DERIVED FROM DIFFERENT 20-CARBON FATTY ACIDS ON PRODUCTION OF MONOCYTE-DERIVED CYTOKINES IN HUMAN WHOLE BLOOD CULTURES

2002 • 74 citations

n-3 fatty acids and leukocyte chemotaxis. Effects in hyperlipidemia and dose-response studies in healthy men.

1991 • 66 citations

The effect of n-3 fatty acids on neutrophil chemiluminescence

1995 • 64 citations

The aetiopathogenesis of inflammatory bowel disease — immunology and repair mechanisms

2004 • 63 citations

Dietary fish oil decreases superoxide generation by human neutrophils: relation to cyclooxygenase pathway and lysosomal enzyme release

1996 • 62 citations

In vitro effects of eicosanoids derived from different 20‐carbon fatty acids on T helper type 1 and T helper type 2 cytokine production in human whole‐blood cultures

2003 • 61 citations

Prostaglandin E2 regulation of the immune response.

1994 • 58 citations

n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production

1996 • 57 citations

Effects of Highly Purified Eicosapentaenoic Acid on Erythrocyte Fatty Acid Composition and Leukocyte and Colonic Mucosa Leukotriene B4 Production in Children With Ulcerative Colitis

2003 • 56 citations

RESTRICTION OF THORACIC RESPIRATION AS AN AID TO ABDOMINAL PALPATION

1949 • 53 citations

Distal proctocolitis and n-3 polyunsaturated fatty acids (n-3 PUFAs): the mucosal effect in situ.

2000 • 51 citations

Evening primose oil and fish oil are ineffective as supplementary treatment of bronchial asthma.

1989 • 51 citations

The effect of eicosapentaenoic acid consumption on human neutrophil chemiluminescence

1991 • 49 citations

The effect of highly purified eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man

1997 • 49 citations

Health effects of omega-3 fatty acids on asthma.

2004 • 44 citations

Dietary N-3 Fatty Acid Supplementation in Rheumatoid Arthritis-Mechanisms, Clinical Outcomes, Controversies, and Future Directions.

1996 • 42 citations

High-dose fish oil and antioxidants in Crohn's disease and the response of bone turnover: a randomised controlled trial

2005 • 42 citations

Adhesion molecules in health and disease

1995 • 41 citations

Anti-inflammatory therapy in cystic fibrosis

2005 • 39 citations

Anti-cytokine therapy in systemic lupus erythematosus

2005 • 38 citations

EICOSANOIDS IN RHEUMATOID ARTHRITIS

1995 • 38 citations

Separation and quantification of PGE3 following derivatization with pancyl bromide by high pressure liquid chromatography with fluorometric detection

1991 • 38 citations

Aging and dietary modulation of elastase and interleukin-1 beta secretion

1995 • 37 citations

Inflammation in Childhood Asthma and Other Wheezing Disorders

2002 • 34 citations

Effect of dietary fish oil supplemented with different doses of vitamin e on neutrophil chemotaxis in healthy volunteers

1992 • 30 citations

Medicinal Fatty Acids in Inflammation

1998 • 29 citations

Inflammation and Neuroaxonal Injury in Multiple Sclerosis and AIDS Dementia Complex: Implications for Neuroprotective Treatment

2005 • 21 citations

n-3 Fatty acids in the treatment of ulcerative colitis

1998 • 18 citations

n-3 Fatty acids in the treatment of rheumatoid arthritis

1998 • 17 citations

The Scientific Basis for Fish Oil Supplementation in Rheumatoid Arthritis

2001 • 10 citations

A new look at the pathophysiology of asthma.

1999 • 8 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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