A Change in the Structure of Vβ Chromatin Associated with TCR β Allelic Exclusion

Translating the Histone Code

2001 • 9,488 citations

The language of covalent histone modifications

2000 • 8,260 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter

2000 • 716 citations

The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition

2000 • 616 citations

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1994 • 539 citations

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

1993 • 528 citations

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

1996 • 469 citations

V(D)J recombination: a functional definition of the joining signals.

1989 • 467 citations

The Complete 685-Kilobase DNA Sequence of the Human β T Cell Receptor Locus

1996 • 434 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus

2000 • 312 citations

Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro

1996 • 305 citations

ACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role ofcis-Acting Elements

1996 • 295 citations

Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ

1987 • 293 citations

A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination

2000 • 286 citations

Antibody regulation of B cell development

2000 • 277 citations

Gcn4 Activator Targets Gcn5 Histone Acetyltransferase to Specific Promoters Independently of Transcription

2000 • 201 citations

Factors and Forces Controlling V(D)J Recombination

2001 • 187 citations

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.

1996 • 179 citations

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule

2000 • 174 citations

Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

1996 • 174 citations

A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes

1985 • 169 citations

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

1996 • 164 citations

Histone Acetylation and hSWI/SNF Remodeling Act in Concert to Stimulate V(D)J Cleavage of Nucleosomal DNA

2000 • 164 citations

Chromatin Remodeling by the T Cell Receptor (Tcr)-β Gene Enhancer during Early T Cell Development

2000 • 161 citations

Accessibility of Nucleosomal DNA to V(D)J Cleavage Is Modulated by RSS Positioning and HMG1

1998 • 161 citations

Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site.

1996 • 156 citations

Essential Role of the Pre-T Cell Receptor in Allelic Exclusion of the T Cell Receptor β Locus

1997 • 146 citations

Control of V(D)J Recombinational Accessibility of the Dβ1 Gene Segment at the TCRβ Locus by a Germline Promoter

1999 • 145 citations

Interleukin 7 Receptor Control of T Cell Receptor γ Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility

1998 • 131 citations

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genes

1993 • 130 citations

Coding end sequence can markedly affect the initiation of V(D)J recombination.

1993 • 125 citations

Stimulation of V(D)J recombination by histone acetylation

2000 • 121 citations

Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain.

1991 • 121 citations

Essential residues in V(D)J recombination signals.

1994 • 111 citations

Chromatin Remodeling at the Ig Loci Prior to V(D)J Recombination

2001 • 104 citations

Histone Acetylation Determines the Developmentally Regulated Accessibility for T Cell Receptor γ Gene Recombination

2001 • 100 citations

Deletion of Germline Promoter PDβ1 from the TCRβ Locus Causes Hypermethylation that Impairs Dβ1 Recombination by Multiple Mechanisms

2000 • 89 citations

Reconstitution of hyperacetylated, DNase I-sensitive chromatin characterized by high conformational flexibility of nucleosomal DNA

1998 • 85 citations

Accessibility and the developmental regulation of V(D)J recombination

1997 • 85 citations

A Developmental Switch from TCRδ Enhancer to TCRα Enhancer Function during Thymocyte Maturation

1999 • 82 citations

Sequence of the Spacer in the Recombination Signal Sequence Affects V(D)J Rearrangement Frequency and Correlates with Nonrandom Vκ Usage In Vivo

1998 • 81 citations

Mechanisms that direct ordered assembly of T cell receptor β locus V, D, and J gene segments

2000 • 76 citations

A conserved sequence in the T-cell receptor beta-chain promoter region.

1988 • 74 citations

Regulation of V(D)J Recombination by Transcriptional Promoters

1999 • 72 citations

Chromatin remodeling directly activates V(D)J recombination

1999 • 71 citations

Enhancer control ofV(D)Jrecombination at the TCRβ locus: differential effects on DNA cleavage and joining

1998 • 71 citations

Biochemical and functional analyses of chromatin changes at the TCR-beta gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation.

1998 • 69 citations

Sequence organisation and transcriptional regulation of the mouse elastase II and trypsln genes

1986 • 67 citations

Regulation of RAG expression in developing lymphocytes

2000 • 63 citations

Unequal Access

2000 • 63 citations

A developmental stage-specific promoter directs germline transcription of D beta J beta gene segments in precursor T lymphocytes.

1998 • 63 citations

How to make ends meet in V(D)J recombination

2001 • 58 citations

Biochemical and Functional Analyses of Chromatin Changes at the TCR-β Gene Locus During CD4−CD8− to CD4+CD8+ Thymocyte Differentiation

1998 • 57 citations

A Developmental Stage-Specific Promoter Directs Germline Transcription of DβJβ Gene Segments in Precursor T Lymphocytes

1998 • 57 citations

Differential Transcriptional Regulation of Individual TCR Vβ Segments Before Gene Rearrangement

2001 • 54 citations

Transcription from a murine T-cell receptor V beta promoter depends on a conserved decamer motif similar to the cyclic AMP response element.

1989 • 48 citations

Mouse VH7183 recombination signal sequences mediate recombination more frequently than those of VHJ558.

1995 • 45 citations

Regulation of Vbeta germline transcription in RAG-deficient mice by the CD3epsilon-mediated signals: implication of Vbeta transcriptional regulation in TCR beta allelic exclusion

1998 • 44 citations

Accessibility Control of V(D)J Recombination: Lessons from Gene Targeting

1998 • 43 citations

Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination

1995 • 41 citations

Coding sequence composition flanking either signal element alters V(D)J recombination efficiency

1995 • 37 citations

The Composition of Coding Joints Formed in V(D)J Recombination Is Strongly Affected by the Nucleotide Sequence of the Coding Ends and Their Relationship to the Recombination Signal Sequences

1997 • 35 citations

Transcription from a Murine T-Cell Receptor Vβ Promoter Depends on a Conserved Decamer Motif Similar to the Cyclic AMP Response Element

1989 • 14 citations

Regulation of Chromatin Accessibility for V(D)J Recombination

1999 • 5 citations