Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule

Somatic generation of antibody diversity

1983 • 3,275 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

CDR3 length in antigen-specific immune receptors.

1994 • 503 citations

V(D)J recombination: a functional definition of the joining signals.

1989 • 467 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian Cells

1998 • 286 citations

The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

1996 • 281 citations

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

1996 • 232 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

Two Pairs of Recombination Signals Are Sufficient to Cause Immunoglobulin V-(D)-J Joining

1987 • 222 citations

Function of the TCRα Enhancer in αβ and γδ T Cells

1997 • 204 citations

Conservation of sequence in recombination signal sequence spacers

1994 • 164 citations

Control of V(D)J Recombinational Accessibility of the Dβ1 Gene Segment at the TCRβ Locus by a Germline Promoter

1999 • 145 citations

Coding end sequence can markedly affect the initiation of V(D)J recombination.

1993 • 125 citations

Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain.

1991 • 121 citations

Immature Thymocytes Employ Distinct Signaling Pathways for Allelic Exclusion versus Differentiation and Expansion

1999 • 120 citations

Developmental regulation of V(D)J recombination and lymphocyte differentiation

1996 • 103 citations

Sequence of the Spacer in the Recombination Signal Sequence Affects V(D)J Rearrangement Frequency and Correlates with Nonrandom Vκ Usage In Vivo

1998 • 81 citations

The basis for the mechanistic bias for deletional over inversional V(D)J recombination.

1992 • 79 citations

Mechanisms that direct ordered assembly of T cell receptor β locus V, D, and J gene segments

2000 • 76 citations

Regulation of V(D)J Recombination by Transcriptional Promoters

1999 • 72 citations

Genomic organization of the mouse T cell receptor V alpha family.

1990 • 72 citations

V(D)J Recombination and Double-Strand Break Repair

1995 • 60 citations

Mouse VH7183 recombination signal sequences mediate recombination more frequently than those of VHJ558.

1995 • 45 citations

Coding sequence composition flanking either signal element alters V(D)J recombination efficiency

1995 • 37 citations

Immunoglobulin D(H) recombination signal sequence targeting: effect of D(H) coding and flanking regions and recombination partner.

1996 • 36 citations

Promoter Element for Transcription of Unrearranged T-Cell Receptor β-Chain Gene in Pro-T Cells

1999 • 35 citations

Lymphoid V(D)J recombination. Functional analysis of the spacer sequence within the recombination signal.

1993 • 26 citations