Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Gain of function mutations in p53

1993 • 876 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

THE ROLE OF DNA METHYLATION IN CANCER GENETICS AND EPIGENETICS

1996 • 480 citations

Down-regulation of bcl-2 by p53 in breast cancer cells.

1994 • 479 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

1999 • 441 citations

HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.

1996 • 318 citations

Regulation of the Human hsp70 Promoter by p53

1993 • 297 citations

Molecular analysis of mbcl-2: Structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma

1987 • 200 citations

Activation of c-myc Gene Expression by Tumor-Derived p53 Mutants Requires a Discrete C-Terminal Domain

1998 • 199 citations

BAG-1L Protein Enhances Androgen Receptor Function

1998 • 195 citations

Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene.

1997 • 188 citations

A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.

1995 • 186 citations

Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest

1998 • 186 citations

Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells

1992 • 161 citations

RAP46 Is a Negative Regulator of Glucocorticoid Receptor Action and Hormone-induced Apoptosis

1998 • 144 citations

Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells

1998 • 144 citations

Mutant p53 protein expression interferes with p53-independent apoptotic pathways

1998 • 138 citations

Negative regulation of Rb expression by the p53 gene product.

1992 • 136 citations

Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors

1998 • 109 citations

Apoptosis: molecular mechanisms and implications for human disease

1995 • 99 citations

`Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain

1998 • 88 citations

The WT1 Protein Is a Negative Regulator of the Normalbcl-2 Allele in t(14;18) Lymphomas

1997 • 77 citations

p53 represses Sp1 DNA binding and HIV-LTR directed transcription.

1997 • 74 citations

π1 Binding Sites Are Negative Regulators of bcl-2 Expression in Pre-B Cells

1995 • 63 citations

Activation of the human immunodeficiency virus type 1 long terminal repeat by transforming mutants of human p53

1994 • 49 citations

Expression of bcl-2, bax, and bcl-XL proteins in azoxymethane-induced rat colonic adenocarcinomas

1997 • 29 citations

The p53 Tumor Suppressor Inhibits Transcription of the TATA-less Mouse DP1 Promoter

1998 • 28 citations

Cloning, characterization, and expression of the transforming growth factor-beta type I receptor promoter in fetal rat bone cells.

1996 • 27 citations

Cloning, characterization, and expression of the transforming growth factor-β type I receptor promoter in fetal rat bone cells

1996 • 26 citations

Expression of cellular genes in HPV16-immortalized and cigarette smoke condensate-transformed human endocervical cells

1997 • 20 citations