Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats

Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

2016 • 11,500 citations

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

2001 • 5,812 citations

Preserving renal function in adults with hypertension and diabetes: A consensus approach

2000 • 1,406 citations

Blood Pressure Control, Proteinuria, and the Progression of Renal Disease

1995 • 1,325 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,265 citations

Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.

1986 • 1,210 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,096 citations

Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat.

1986 • 1,071 citations

Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene

1990 • 913 citations

EARLY AGGRESSIVE ANTIHYPERTENSIVE TREATMENT REDUCES RATE OF DECLINE IN KIDNEY FUNCTION IN DIABETIC NEPHROPATHY

1983 • 884 citations

End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions

1999 • 796 citations

The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?

1999 • 623 citations

Hemodynamically mediated glomerular injury and the progressive nature of kidney disease

1983 • 607 citations

Validation in awake rats of a tail-cuff method for measuring systolic pressure.

1973 • 492 citations

The Modification of Diet in Renal Disease Study

1989 • 434 citations

Application of Photoshop-based Image Analysis to Quantification of Hormone Receptor Expression in Breast Cancer

1997 • 319 citations

Oral renin inhibitors

2006 • 289 citations

Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats

2005 • 247 citations

Renal interstitial expansion in insulin-dependent diabetes mellitus

1993 • 229 citations

Complete Chromogen Separation and Analysis in Double Immunohistochemical Stains Using Photoshop-based Image Analysis

1999 • 225 citations

Renoprotective Effects of Adding Angiotensin II Receptor Blocker to Maximal Recommended Doses of ACE Inhibitor in Diabetic Nephropathy

2003 • 222 citations

Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbuminuria

2005 • 221 citations

Expression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition.

1998 • 203 citations

Structure and Function of the Kidney in Diabetic Glomerulosclerosis

1980 • 186 citations

A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR)

1998 • 166 citations

Protein Kinase C β Inhibition Attenuates the Progression of Experimental Diabetic Nephropathy in the Presence of Continued Hypertension

2003 • 165 citations

Aminoguanidine Ameliorates Overexpression of Prosclerotic Growth Factors and Collagen Deposition in Experimental Diabetic Nephropathy

2001 • 133 citations

Angiotensin and Bradykinin Peptides in the TGR(mRen-2)27 Rat

1995 • 121 citations

Local Renal Aldosterone System and Its Regulation by Salt, Diabetes, and Angiotensin II Type 1 Receptor

2005 • 119 citations

Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium.

1993 • 111 citations

Expansion of Cortical Interstitium Is Limited by Converting Enzyme Inhibition in Type 2 Diabetic Patients with Glomerulosclerosis

1999 • 108 citations

Sodium-lithium countertransport

1998 • 92 citations

Effects of perindopril on renal histomorphometry in diabetic subjects with microalbuminuria: A 3-year placebo-controlled biopsy study

1998 • 59 citations

Role of local and systemic angiotensin in diabetic renal disease.

1997 • 55 citations

Increased bradykinin and “normal” angiotensin peptide levels in diabetic Sprague-Dawley and transgenic (mRen-2)27 rats

1999 • 54 citations

Safety and Tolerability of High-Dose Angiotensin Receptor Blocker Therapy in Patients with Chronic Kidney Disease: A Pilot Study

2004 • 53 citations

Mechanism of progression of renal disease: current hemodynamic concepts.

1998 • 23 citations

Effects of Low-Dose and Early versus Late Perindopril Treatment on the Progression of Severe Diabetic Nephropathy in (mREN-2)27 Rats

2002 • 19 citations

Specific and non-specific measurements of tissue angiotensin II cascade members

2001 • 15 citations