Slowly Progressive, Angiotensin II–Independent Glomerulosclerosis in Human (Pro)renin Receptor–Transgenic Rats

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,265 citations

Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle” region for nonproteolytic activation of prorenin

2004 • 437 citations

Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms

2005 • 424 citations

Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach

2005 • 333 citations

Prorenin Receptor Blockade Inhibits Development of Glomerulosclerosis in Diabetic Angiotensin II Type 1a Receptor–Deficient Mice

2006 • 280 citations

Nonproteolytic Activation of Prorenin Contributes to Development of Cardiac Fibrosis in Genetic Hypertension

2006 • 261 citations

Elevated Blood Pressure and Heart Rate in Human Renin Receptor Transgenic Rats

2006 • 221 citations

Human Prorenin Has “Gate and Handle” Regions for Its Non-proteolytic Activation

2003 • 187 citations

Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system

2006 • 160 citations

Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats

2006 • 151 citations

Contribution of Nonproteolytically Activated Prorenin in Glomeruli to Hypertensive Renal Damage

2006 • 140 citations

Renal Interstitial Fluid Angiotensin I and Angiotensin II Concentrations during Local Angiotensin-Converting Enzyme Inhibition

2002 • 102 citations

Isolation and characterization of native human renin derived from Chinese hamster ovary cells

1986 • 91 citations

Novel Integrative Approaches to the Identification of Candidate Genes in Hypertension

2005 • 90 citations

Cyclooxygenase-2 participates in tubular flow-dependent afferent arteriolar tone: interaction with neuronal NOS

1998 • 90 citations

TGF-β₁ stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process

2005 • 67 citations

ERK-dependent Signaling Pathway and Transcriptional Factor Ets-1 Regulate Matrix Metalloproteinase-9 Production in Transforming Growth Factor-β1 Stimulated Glomerular Podocytes

2005 • 37 citations

Highly Sensitive Microplate-Elisa for Angiotensin I Using 3,3′,5,5′-Tetramethylbenzidine

1990 • 29 citations

The Dominant Role of the Prosegment of Prorenin in Determining the Rate of Activation by Acid or Trypsin: Studies with Molecular Chimeras

2000 • 29 citations

<b>PURIFICATION AND SOME PROPERTIES OF RECOMBINANT SHEEP ANGIOTENSINOGEN EXPRESSED IN CHINESE HAMSTER OVARY </b><b>CELLS </b>

1997 • 20 citations

Expression of Rat Renin in Mammalian Cells and Its Purification

1992 • 15 citations