Effects of Aliskiren on Blood Pressure, Albuminuria, and (Pro)Renin Receptor Expression in Diabetic TG(mRen-2)27 Rats

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,265 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,096 citations

Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL

2004 • 956 citations

Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene

1990 • 913 citations

Aliskiren, a Novel Orally Effective Renin Inhibitor, Provides Dose-Dependent Antihypertensive Efficacy and Placebo-Like Tolerability in Hypertensive Patients

2005 • 522 citations

Interactions of Transforming Growth Factor-β and Angiotensin II in Renal Fibrosis

1998 • 441 citations

Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle” region for nonproteolytic activation of prorenin

2004 • 437 citations

Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms

2005 • 424 citations

Blood Pressure Lowering in Essential Hypertension With an Oral Renin Inhibitor, Aliskiren

2003 • 338 citations

A Novel Signal Transduction Cascade Involving Direct Physical Interaction of the Renin/Prorenin Receptor With the Transcription Factor Promyelocytic Zinc Finger Protein

2006 • 304 citations

Prorenin Receptor Blockade Inhibits Development of Glomerulosclerosis in Diabetic Angiotensin II Type 1a Receptor–Deficient Mice

2006 • 280 citations

Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats

2005 • 247 citations

Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen

1996 • 245 citations

Renin-stimulated TGF-β1 expression is regulated by a mitogen-activated protein kinase in mesangial cells

2007 • 237 citations

Elevated Blood Pressure and Heart Rate in Human Renin Receptor Transgenic Rats

2006 • 221 citations

Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver.

1996 • 175 citations

Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats

2007 • 167 citations

A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR)

1998 • 166 citations

Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system

2006 • 160 citations

High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes

2007 • 142 citations

Tissue activity of circulating prorenin

2002 • 74 citations

Nonproteolytic “activation” of prorenin by active site-directed renin inhibitors as demonstrated by renin-specific monoclonal antibody

1992 • 62 citations

Conformational changes in prorenin during renin inhibition in vitro and in vivo

2006 • 40 citations

Renal function in hypertensive rats transgenic for mouse renin gene

1994 • 35 citations

Developmental studies demonstrate age-dependent elevation of renin activity in TGR(mRen2)27 rats

1995 • 29 citations

Effects of Valsartan and Hydrochlorothiazide Alone and in Combination on Blood Pressure and Heart Rate in Conscious-Telemetered Spontaneously Hypertensive Rats (SHR)

1998 • 20 citations

A Rapid and Large-Scale Isolation of Renin from Mouse Submaxillary Gland by Pepstatin-Aminohexyl-Agarose Affinity Chromatography<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>

1981 • 18 citations