Change in Proteinuria After Adding Aldosterone Blockers to ACE Inhibitors or Angiotensin Receptor Blockers in CKD: A Systematic Review

Assessing the quality of reports of randomized clinical trials: Is blinding necessary?

1996 • 17,261 citations

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

1999 • 8,588 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

2001 • 5,812 citations

Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials

1995 • 5,696 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction

2003 • 4,640 citations

Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?

1998 • 3,578 citations

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

2000 • 2,991 citations

Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third national health and nutrition examination survey

2002 • 2,777 citations

Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study

2004 • 1,698 citations

K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease

2004 • 1,195 citations

RETRACTED: Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial

2003 • 974 citations

Comparison of Candesartan, Enalapril, and Their Combination in Congestive Heart Failure

1999 • 898 citations

Effects of Eplerenone, Enalapril, and Eplerenone/Enalapril in Patients With Essential Hypertension and Left Ventricular Hypertrophy

2003 • 628 citations

Maintenance Dialysis Population Dynamics

2002 • 615 citations

Role of aldosterone in the remnant kidney model in the rat.

1996 • 473 citations

Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy*

2000 • 459 citations

Effectiveness of Aldosterone Blockade in Patients With Diabetic Nephropathy

2003 • 458 citations

Selective Aldosterone Blockade with Eplerenone Reduces Albuminuria in Patients with Type 2 Diabetes

2006 • 446 citations

Clinical characteristics of primary aldosteronism from an analysis of 145 cases

1964 • 425 citations

An evidence based approach to individualising treatment

1995 • 369 citations

RISE IN PLASMA CONCENTRATION OF ALDOSTERONE DURING LONG-TERM ANGIOTENSIN II SUPPRESSION

1981 • 330 citations

Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease

2006 • 323 citations

Role of Aldosterone in Renal Vascular Injury in Stroke-Prone Hypertensive Rats

1999 • 311 citations

Effects of the Selective Aldosterone Blocker Eplerenone Versus the Calcium Antagonist Amlodipine in Systolic Hypertension

2003 • 295 citations

Beneficial Effects of Adding Spironolactone to Recommended Antihypertensive Treatment in Diabetic Nephropathy

2005 • 288 citations

Aldosterone in the development and progression of renal injury

2004 • 264 citations

Combination Therapy With an Angiotensin Receptor Blocker and an ACE Inhibitor in Proteinuric Renal Disease: A Systematic Review of the Efficacy and Safety Data

2006 • 247 citations

Antihypertensive therapy with MK 421: angiotensin II--renin relationships to evaluate efficacy of converting enzyme blockade.

1982 • 243 citations

Podocyte Injury Underlies the Glomerulopathy of Dahl Salt-Hypertensive Rats and Is Reversed by Aldosterone Blocker

2006 • 243 citations

Aldosterone escape during blockade of the renin?angiotensin?aldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate

2004 • 230 citations

Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in chronic heart failure

1996 • 229 citations

Beneficial impact of spironolactone in diabetic nephropathy

2005 • 226 citations

Efficacy and tolerability of eplerenone and losartan in hypertensive black and white patients

2003 • 225 citations

Double-Blind, Placebo-Controlled Study on the Effect of the Aldosterone Receptor Antagonist Spironolactone in Patients Who Have Persistent Proteinuria and Are on Long-Term Angiotensin-Converting Enzyme Inhibitor Therapy, with or without an Angiotensin II Receptor Blocker

2006 • 209 citations

Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy

2006 • 209 citations

?Escape? of aldosterone production in patients with left ventricular dysfunction treated with an angiotensin converting enzyme inhibitor: Implications for therapy

1995 • 206 citations

Antihypertensive Therapy with MK 4211

1982 • 188 citations

Spironolactone in type 2 diabetic nephropathy: effects on proteinuria, blood pressure and renal function

2006 • 179 citations

Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension

2004 • 165 citations

The effect of spironolactone, cilazapril and their combination on albuminuria in patients with hypertension and diabetic nephropathy is independent of blood pressure reduction: a randomized controlled study

2004 • 145 citations

Aldosterone Escape during Angiotensinconverting Enzyme Inhibitor Therapy in Essential Hypertensive Patients with Left Ventricular Hypertrophy

2001 • 144 citations

Antagonists of Aldosterone and Proteinuria in Patients With CKD: An Uncontrolled Pilot Study

2005 • 141 citations

Failure of aldosterone suppression despite angiotensin-converting enzyme (ACE) inhibitor administration in chronic heart failure is associated with ACE DD genotype

2001 • 140 citations

Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy

2000 • 130 citations

Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease

2005 • 129 citations

Antiproteinuric efficacy of eplerenone, enalapril, and eplerenone/enalapril combination therapy in diabetic hypertensives with microalbuminuria

2002 • 120 citations

Aldosterone and cardiac fibrosis: in vitro studies

1994 • 108 citations

Aldosterone Blockade Attenuates Urinary Monocyte Chemoattractant Protein-1 and Oxidative Stress in Patients with Type 2 Diabetes Complicated by Diabetic Nephropathy

2006 • 108 citations

Neurohormonal reactivation in heart failure patients on chronic ACE inhibitor therapy: a longitudinal study

1999 • 73 citations

Aldosterone breakthrough during therapy with angiotensin‐converting enzyme inhibitors and angiotensin II receptor blockers in proteinuric patients with immunoglobulin A nephropathy

2006 • 73 citations

RAAS escape: A real clinical entity that may be important in the progression of cardiovascular and renal disease

2003 • 68 citations

Aldosterone Antagonism Ameliorates Proteinuria and Nephrosclerosis Independent of Glomerular Dynamics in <i>L</i>-NAME/SHR Model

2004 • 66 citations

Molecular Mechanisms and Therapeutic Strategies of Chronic Renal Injury: Renoprotective Effects of Aldosterone Blockade

2006 • 65 citations

Spironolactone in Combination with Cilazapril Ameliorates Proteinuria and Renal Interstitial Fibrosis in Rats with Anti-Thy-1 Irreversible Nephritis

2004 • 29 citations