A Serotonin Transporter Gene Promoter Polymorphism (5-HTTLPR) and Prefrontal Cortical Binding in Major Depression and Suicide

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

1996 • 5,154 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

Cross-National Epidemiology of Major Depression and Bipolar Disorder

1996 • 2,176 citations

Toward a Clinical Model of Suicidal Behavior in Psychiatric Patients

1999 • 1,723 citations

The Return of Phineas Gage: Clues About the Brain from the Skull of a Famous Patient

1994 • 1,449 citations

Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior

1983 • 1,290 citations

Serotonergic Studies in Patients With Affective and Personality Disorders

1989 • 1,093 citations

Serotonin Function and the Mechanism of Antidepressant Action

1990 • 911 citations

Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter

1994 • 904 citations

A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders.

1996 • 667 citations

Factor Analysis of Some Psychometric Measures of Impulsiveness and Anxiety

1965 • 563 citations

Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography

1998 • 507 citations

The domain of supervisory processes and the temporal organization of behaviour

1998 • 492 citations

Tritiated Imipramine Binding Sites Are Decreased in the Frontal Cortex of Suicides

1982 • 478 citations

The neurobiology of suicide

1998 • 475 citations

Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims

1995 • 461 citations

Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects

1997 • 441 citations

Autoradiographic Demonstration of Increased Serotonin 5-HT2 and β-Adrenergic Receptor Binding Sites in the Brain of Suicide Victims

1990 • 411 citations

Cocaine, Ethanol, and Genotype Effects on Human Midbrain Serotonin Transporter Binding Sites and mRNA Levels

1998 • 390 citations

Cortisol Production in Depressive Illness

1970 • 371 citations

Cerebrospinal Fluid Monoamine Metabolite Levels in Male Arsonists

1987 • 370 citations

Alcohol and Central Serotonin Metabolism in Man

1979 • 368 citations

Effects of Chronic Antidepressant Treatments on Serotonin Transporter Function, Density, and mRNA Level

1999 • 336 citations

5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala

1993 • 316 citations

Reduced Central Serotonin Transporters in Alcoholism

1998 • 316 citations

CSF and Urinary Biogenic Amines and Metabolites in Depression and Mania

1983 • 315 citations

Urinary free Cortisol excretion in depression

1976 • 310 citations

Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder

1997 • 305 citations

A Tryptophan Hydroxylase Gene Marker for Suicidality and Alcoholism

1998 • 305 citations

Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides

1984 • 301 citations

CSF monoamine metabolites in melancholia

1984 • 286 citations

Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene

1999 • 283 citations

Cerebrospinal Fluid Monoamine Metabolites and Suicidal Behavior in Depressed Patients

1989 • 281 citations

Serotonergic Function in Depression

1984 • 280 citations

Validity of DSM‐III‐R diagnosis by psychological autopsy: a comparison with clinician ante‐mortem diagnosis

1996 • 276 citations

Relationship Between Central and Peripheral Serotonin Indexes in Depressed and Suicidal Psychiatric Inpatients

1992 • 275 citations

Parachlorophenylalanine Reversal of Tranylcypromine Effects in Depressed Patients

1976 • 263 citations

Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABAα6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study

1999 • 258 citations

CSF 5‐HIAA Predicts Suicide Risk After Attempted Suicide

1994 • 257 citations

Decreased Imipramine Binding in the Brains of Patients with Depressive Illness

1983 • 253 citations

Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders

1998 • 248 citations

Stability of interindividual differences in serotonin function and its relationship to severe aggression and competent social behavior in Rhesus Macaque females

1996 • 248 citations

Relationship of Psychobiological Variables to Recidivism in Violent Offenders and Impulsive Fire Setters

1989 • 244 citations

Plasma prolactin changes following fenfluramine in depressed patients compared to controls: An evaluation of central serotonergic responsibility in depression

1984 • 241 citations

SEX STEROID CONTROL OF MOOD, MENTAL STATE AND MEMORY

1998 • 240 citations

Selective Abnormalities of Prefrontal Serotonergic Receptors in Schizophrenia

1993 • 234 citations

CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls

1984 • 214 citations

Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence.

1995 • 213 citations

Prolactin and cortisol responses to d-fenfluramine in major depression: evidence for diminished responsivity of central serotonergic function

1991 • 201 citations

Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder

1998 • 190 citations

Estradiol-17β increase serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain

1997 • 187 citations

Evidence for the 5-HT Hypothesis of Suicide A Review of Post-mortem Studies

1989 • 180 citations

Human brain receptor alterations in suicide victims

1982 • 179 citations

Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients

1997 • 179 citations

Biogenic Amine Metabolites in Cerebrospinal Fluid of Depressed and Manic Patients

1972 • 178 citations

Attempted suicide among living co-twins of twin suicide victims

1995 • 165 citations

Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims

1999 • 164 citations

Hostility and Depression Associated with Suicide Attempts

1973 • 161 citations

No association between the serotonin transporter gene regulatory region polymorphism and the Tridimensional Personality Questionnaire (TPQ) temperament of harm avoidance

1997 • 160 citations

A Prospective Follow-up Study of Alcoholic Violent Offenders and Fire Setters

1996 • 158 citations

Serotonergic mechanisms in brains of suicide victims

1986 • 153 citations

Association Analysis of a Regulatory Variation of the Serotonin Transporter Gene with Severe Alcohol Dependence

1997 • 153 citations

Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour

1997 • 150 citations

Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT)

1997 • 150 citations

Relationship of Psychopathology to the Human Serotonin1B Genotype and Receptor Binding Kinetics in Postmortem Brain Tissue

1999 • 149 citations

Central serotonin metabolism and frequency of depression

1979 • 136 citations

The serotonin transporter gene and peer-rated neuroticism

1997 • 135 citations

Psychobiology of suicidal behavior.

1986 • 135 citations

Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers

1997 • 126 citations

Brief research communication: serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders

1998 • 126 citations

An Overview

1986 • 122 citations

5-Hydroxyindolacetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis

1972 • 116 citations

Autoradiographic Analysis of Tritiated Imipramine Binding in the Human Brain Post Mortem: Effects of Suicide

1989 • 114 citations

Cerebrospinal fluid monoamine and monoamine metabolite concentrations in melancholia

1985 • 112 citations

Tryptophan depletion and depressive vulnerability

1999 • 111 citations

Alternative Splicing of the Human Serotonin Transporter Gene

1997 • 110 citations

The Neuropharmacology of Serotonin

1990 • 110 citations

Serotonin transporter (SERT) mRNA and binding site densities in male rat brain affected by sex steroids

1999 • 109 citations

Early-onset substance abuse and community violence by outpatients with chronic mental illness

1997 • 108 citations

Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells

1999 • 98 citations

Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine

1988 • 97 citations

Further studies on platelet serotonin transporter binding in depression

1994 • 97 citations

Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness

1973 • 94 citations

Therapeutic effects of serotonin uptake inhibitors in depression.

1986 • 93 citations

Violence and aggression

2018 • 92 citations

Effects of adrenalectomy and type I or type II glucocorticoid receptor activation on 5-HT1A and 5-HT2 receptor binding and 5-HT transporter mRNA expression in rat brain

1994 • 91 citations

Prediction of Suicidal Behavior from Biologic Tests

1992 • 87 citations

Serotonin Transporter Gene and Risk for Bipolar Affective Disorder: An Association Study in a Spanish Population

1998 • 85 citations

Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides

1990 • 85 citations

Serotonin function and depression: neuroendocrine and mood responses to intravenous L-tryptophan in depressed patients and healthy comparison subjects

1991 • 83 citations

Genetic Association Analysis of Serotonin System Genes in Bipolar Affective Disorder

1999 • 83 citations

Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder

1997 • 79 citations

Effects of Serotonin Transporter Promoter Genotype on Platelet Serotonin Transporter Functionality in Depressed Children and Adolescents

1999 • 79 citations

Cerebrospinal Fluid Amine Metabolites

1986 • 76 citations

Postmortem Neurochemical Studies in Depression

1986 • 72 citations

3H-imipramine binding in the frontal cortex of suicides

1989 • 70 citations

Genetic and biologic risk factors for suicide in depressive disorders

1993 • 66 citations

Serotonergic split brain and suicide

1987 • 61 citations

The neurobiology of suicide: From the bench to the clinic.

2004 • 60 citations

Recovery from Major Depression Is Not Associated with Normalization of Serotonergic Function

1998 • 59 citations

History of Serotonin and Serotonin Disorders

1990 • 57 citations

Systematic screening for mutations in the coding region of the human serotonin transporter (5-HTT) gene using PCR and DGGE

1996 • 57 citations

LUMBAR CSF 5- HYDROXYINDOLEACETIC ACID AND HOMOVANILLIC ACID IN AFFECTIVE SYNDROMES

1974 • 56 citations

Adrenocortical hyperactivity in depression: Effects of agitation, delusions, melancholia, and other illness variables

1988 • 56 citations

Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics

1997 • 53 citations

Lower3H-paroxetine binding in cerebral cortex of suicide victims is partly due to fewer high affinity, non-transporter sites

1996 • 52 citations

Serotonin transporter candidate gene studies in affective disorders and personality: promises and potential pitfalls

1998 • 50 citations

Bipolar disorder and the serotonin transporter gene: a family-based association study

1999 • 43 citations

Genetic linkage study of bipolar disorder and the serotonin transporter

1996 • 42 citations

Laterality and 3H-imipramine binding: Studies in the frontal cortex of normal controls and suicide victims

1991 • 41 citations

Blunted growth hormone and prolactin responses to L-tryptophan in depression; a state-dependent abnormality

1991 • 40 citations

Platelet Serotonin Transporter in Depressed Children and Adolescents: 3H‐Paroxetine Platelet Binding Before and After Sertraline

1998 • 39 citations

Reversed hemispheric asymmetry of imipramine binding in suicide victims

1991 • 37 citations

Relevance of serotonergic postmortem studies to suicidal behavior

1992 • 35 citations

Serotonin transporter gene is not associated with symptomatology of schizophrenia

1999 • 32 citations

Serotonin transporter gene (HTTLPR) is not in linkage disequilibrium with prepubertal and early adolescent bipolarity

1999 • 31 citations

Symmetrical hemispheric distribution of 3H-Paroxetine binding sites in postmortem human brain from controls and suicides

1990 • 28 citations

Suicide Research

1997 • 27 citations

A functional variant of the serotonin transporter gene in families with bipolar affective disorder

1998 • 26 citations

Serotonin transporter gene not associated with psychotic symptomatology of mood disorders

1999 • 24 citations

Methodological Strategies in Suicidea

1986 • 16 citations

Effect of amitriptyline on endocrine responses to intravenous L-trytophan

1990 • 14 citations

Serotonin and Major Depression

1993 • 13 citations

Estimation of Brain Amine Metabolism in Affective Illness: Cerebrospinal Fluid Studies Utilizing Probenecid

1974 • 13 citations