Serotonin Function and the Mechanism of Antidepressant Action

THE ASSESSMENT OF ANXIETY STATES BY RATING

1959 • 10,517 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

The Biochemistry of Affective Disorders

1967 • 1,183 citations

Effects of ingestion of disproportionate amounts of amino acids.

1970 • 1,123 citations

Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised

1988 • 1,038 citations

Tryptophan depletion causes a rapid lowering of mood in normal males

1985 • 726 citations

Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment

1981 • 645 citations

Increased Serotonin2 and β-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims

1986 • 552 citations

INCREASED SEROTONIN-2 BINDING SITES IN FRONTAL CORTEX OF SUICIDE VICTIMS

1983 • 527 citations

Overview: toward a dysregulation hypothesis of depression

1985 • 519 citations

THE EFFECTS OF PRECURSOR LOADING IN THE CEREBRAL METABOLISM OF 5‐HYDROXYINDOLES

1968 • 399 citations

Zur Serotonin-Hypothese der Depression*

1990 • 397 citations

Serotonergic Function in Depression

1984 • 280 citations

Free tryptophan in serum controls brain tryptophan level and serotonin synthesis

1973 • 266 citations

Parachlorophenylalanine Reversal of Tranylcypromine Effects in Depressed Patients

1976 • 263 citations

Carbon Dioxide—Induced Anxiety

1988 • 258 citations

Plasma prolactin changes following fenfluramine in depressed patients compared to controls: An evaluation of central serotonergic responsibility in depression

1984 • 241 citations

Altered neuropeptide concentrations in cerebrospinal fluid of psychiatric patients

1982 • 192 citations

Biochemical aspects of tryptophan depletion in primates

1989 • 190 citations

CSF Somatostatin in Affective Illness

1983 • 190 citations

THE AMINO ACID REQUIREMENTS OF MAN

1951 • 171 citations

Correlation between brain tryptophan and plasma neutral amino acid levels following food consumption in rats

1973 • 170 citations

Effects of the diet on brain neurotransmitters

1977 • 164 citations

Dose-response decrease in plasma tryptophan and in brain tryptophan and serotonin after tryptophan-free amino acid mixtures in rats

1989 • 161 citations

Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients.

1975 • 156 citations

Management of depression with serotonin precursors.

1981 • 154 citations

Hormonal probes of central serotonergic activity: Do they really exist?

1987 • 148 citations

Effects of Long-Term Corn Consumption on Brain Serotonin and the Response to Electric Shock

1975 • 143 citations

Serotonin Function and Mechanism of Action of Antidepressant Treatment

1984 • 143 citations

Manipulations of dietary tryptophan: Effects on mouse killing and brain serotonin in the rat

1979 • 137 citations

Neuroendocrine Responses to Intravenous Tryptophan in Major Depression

1987 • 131 citations

Plasma Tryptophan Response Curve and Its Relation to Tryptophan Requirements in Young Adult Men

1971 • 126 citations

Neuroendocrine and behavioral effects of dietary tryptophan restriction in healthy subjects

1989 • 126 citations

THE AMINO ACID REQUIREMENTS OF MAN

1954 • 125 citations

A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males

1987 • 122 citations

Dietary regulation of brain tryptophan metabolism by plasma ratio of free tryptophan and neutral amino acids in humans

1974 • 110 citations

Reliability and Validity of the Symptoms of Major Depressive Illness

1986 • 104 citations

Low levels of somatostatin in human CSF mark depressive episodes

1984 • 89 citations

In vivo measurement of 5-hydroxytryptamine turnover rate in the rat brain from the conversion of C14-tryptophan to C14-5-hydroxytryptamine.

1969 • 77 citations

Relationships Between Plasma, CSF and Brain Tryptophan

1979 • 77 citations

Interaction of diet and drugs in the regulation of brain 5-hydroxyindoles and the response to painful electric shock

1976 • 71 citations

Efficacy of fluvoxamine in treatment-refractory depression

1988 • 64 citations

Therapeutic indications for serotonin-potentiating compounds: A hypothesis

1987 • 62 citations

Effect of a Tryptophan Deficient Diet on Brain Serotonin and Plasma Tryptophan Level.

1963 • 52 citations

Studies on the Metabolism of 5-Hydroxytryptamine (Serotonin) II. Effect of Tryptophan Deficiency in Rats

1962 • 45 citations

Tryptophan Intake, Spacing of Meals, and Diurnal Fluctuations of Plasma Tryptophan in Men

1969 • 43 citations

Rapid repletion of brain serotonin in malnourished corn-fed rats following L-tryptophan injection

1975 • 42 citations

Tryptophan-free diet: Effects on the acoustic startle reflex in rats

1979 • 42 citations

Effects of antidepressant treatments on 5-HT neurotransmission: electrophysiological and clinical studies.

1984 • 38 citations

Reduction of REM sleep by a tryptophan-free amino acid diet

1979 • 35 citations

Brain and CSF somatostatin concentrations in patients with psychiatric or neurological illness An overview

1988 • 33 citations

Tryptophan Deprivation: Effects on Mouse-killing and Reactivity in the Rat

1981 • 32 citations

The Effect of a Tryptophan-Free Diet on Prolactin and Corticosterone Release by Serotonergic Stimuli

1980 • 30 citations

Influence of Plasma Tryptophan on Brain 5HT Synthesis and Serotonergic Activity

1981 • 24 citations

Central 5-HT neurons as targets for antidepressant drug action: differential modulation of 5-HT receptor populations in the central nervous system of the rat.

1984 • 9 citations