A specific 15-lipoxygenase inhibitor limits the progression and monocyte–macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit

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Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.

1992 • 828 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

Selected histochemical and histopathological methods

1966 • 524 citations

Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells.

1995 • 461 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

Rapid separation and quantification of lipid classes by high performance liquid chromatography and mass (light-scattering) detection.

1985 • 384 citations

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

1992 • 382 citations

The antioxidant butylated hydroxytoluene protects against atherosclerosis.

1991 • 362 citations

Immunocytochemical analysis of cellular components in atherosclerotic lesions. Use of monoclonal antibodies with the Watanabe and fat-fed rabbit.

1986 • 296 citations

Lipid in the aortic intima the correlation of morphological and chemical characteristics

1967 • 266 citations

A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes.

1985 • 257 citations

Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques.

1995 • 247 citations

Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.

1996 • 234 citations

Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages

1991 • 223 citations

Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and within rabbit atheroma.

1993 • 205 citations

Involvement of 15-lipoxygenase in early stages of atherogenesis.

1994 • 196 citations

Attenuation of diet‐induced atherosclerosis in rabbits with a highly selective 15‐lipoxygenase inhibitor lacking significant antioxidant properties

1997 • 178 citations

Regulation of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in human vascular smooth muscle cells.

1994 • 160 citations

Rapid on-line determination of cholesterol distribution among plasma lipoproteins after high-performance gel filtration chromatography

1991 • 143 citations

Probucol attenuates the development of aortic atherosclerosis in cholesterol‐fed rabbits

1989 • 142 citations

The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation

1993 • 113 citations

The effects of probucol on the progression of atherosclerosis in mature Watanabe heritable hyperlipidaemic rabbits

1991 • 93 citations

Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation

1994 • 82 citations

Quantitative ultrastructural analysis of perifibrous lipid and its association with elastin in nonatherosclerotic human aorta.

1985 • 77 citations

Lipoxygenase metabolites induced expression of adhesion molecules and transendothelial migration of monocyte-like HL-60 cells is linked to protein kinase C activation

1996 • 77 citations

Induction of 15-Lipoxygenase mRNA and Protein in Early Atherosclerotic Lesions

1995 • 73 citations

Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E

1989 • 66 citations

Triglyceride-rich lipoproteins and atherosclerosis: pathophysiological considerations.

1994 • 49 citations

Antiatherosclerotic effects of antioxidants are lesion-specific when evaluated in hypercholesterolemic New Zealand White rabbits

1992 • 45 citations

Effect of Probucol, Pantethine and Their Combinations on Serum Lipoprotein Metabolism and on the Incidence of Atheromatous Lesions in the Rabbit

1986 • 44 citations

Actions of vitamins A and E and some nicotinic acid derivatives on plasma lipids and on lipid infiltration of aorta in cholesterol-fed rabbits

1975 • 38 citations

Gene expression in atherosclerotic lesions.

1992 • 26 citations

Evidence for an inverse relation between plasma triglyceride and aortic cholesterol in the coconut oil/cholesterol-fed rabbit

1988 • 23 citations

Transient Overexpression of Human 15-Lipoxygenase in Aortic Endothelial Cells Enhances Tumor Necrosis Factor-Induced Vascular Cell Adhesion Molecule-1 Gene Expression

1996 • 17 citations

Indolothiopyrylium Compounds. I. Benz[b]indolo[2,3-d]thiopyrylium Perchlorates. A Novel Heteroaromatic Ring System¹

1965 • 9 citations

3.P.384 15-lipoxygenase overexpression induces atherosclerosis in LDL deficient mice

1997 • 8 citations