Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

Enzymatic Determination of Total Serum Cholesterol

1974 • 9,182 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

An Introduction to Statistical Methods and Data Analysis

1994 • 5,244 citations

Quantitative Determination of Serum Triglycerides by the Use of Enzymes

1973 • 3,206 citations

The Image Processing Handbook

2006 • 2,133 citations

The Liver: Biology and Pathobiology.

1983 • 1,628 citations

Coronary Angiographic Changes with Lovastatin Therapy: The Monitored Atherosclerosis Regression Study (MARS)

1993 • 637 citations

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 562 citations

Selected Histochemical and Histopathological Methods

1966 • 534 citations

Selected histochemical and histopathological methods

1966 • 524 citations

The Liver: Biology and Pathobiology

1983 • 508 citations

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

1981 • 424 citations

Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat

1983 • 414 citations

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

1986 • 376 citations

Immunocytochemical analysis of cellular components in atherosclerotic lesions. Use of monoclonal antibodies with the Watanabe and fat-fed rabbit.

1986 • 296 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side-chain ester derivatives of mevinolin

1986 • 261 citations

Inhibition of Cholesterol Synthesis in vitro and in vivo by ML‐236A and ML‐236B, Competitive Inhibitors of 3‐Hydroxy‐3‐methylglutaryl‐Coenzyme A Reductase

1977 • 261 citations

A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes.

1985 • 257 citations

HMG CoA reductase inhibitors. In vivo effects on carotid intimal thickening in normocholesterolemic rabbits.

1993 • 229 citations

Regulation of rates of cholesterol synthesis in vivo in the liver and carcass of the rat measured using [3H]water.

1980 • 228 citations

Simvastatin

1990 • 219 citations

HMG CoA reductase inhibitors

1992 • 195 citations

Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

1990 • 171 citations

Cholesterol is required for secretion of very-low-density lipoprotein by rat liver

1989 • 160 citations

The prenylation of proteins

1992 • 160 citations

Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation.

1991 • 158 citations

Rapid on-line determination of cholesterol distribution among plasma lipoproteins after high-performance gel filtration chromatography

1991 • 143 citations

Pravastatin

1991 • 117 citations

The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation

1993 • 113 citations

Tissue-selective acute effects of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase on cholesterol biosynthesis in lens.

1989 • 105 citations

Inhibition of cultured vascular smooth muscle cell migration by simvastatin (MK-733)

1992 • 95 citations

Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits.

1989 • 95 citations

Effects of lovastatin therapy on very-low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: Evidence for reduced assembly and secretion of triglyceride-rich lipoproteins

1992 • 91 citations

Regulation of sterol synthesis in 16 tissues of rat. I. Effect of diurnal light cycling, fasting, stress, manipulation of enterohepatic circulation, and administration of chylomicrons and triton.

1977 • 90 citations

Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: Comparison with selected HMG-CoA reductase inhibitors

1992 • 87 citations

Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes

1991 • 76 citations

Selected methods for the small clinical chemistry laboratory

1982 • 75 citations

Selective inhibition of cholesterol synthesis in liver versus extrahepatic tissues by HMG-CoA reductase inhibitors.

1990 • 74 citations

Effect of Lovastatin on Suppression and Regression of Atherosclerosis in Lipid-Fed Rabbits

1992 • 61 citations

Suppression of established atherosclerosis and xanthomas in mature WHHL rabbits by keeping their serum cholesterol levels extremely low

1990 • 59 citations

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase

1991 • 59 citations

Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits.

1989 • 58 citations

Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductase

1990 • 56 citations

Influence of dietary cholesterol, saturated and unsaturated lipid on 3-hydroxy-3-methylglutaryl CoA reductase activity in rabbit intestine and liver.

1981 • 51 citations

Effect of CS-514 (pravastatin) on VLDL-triglyceride kinetics in rats

1988 • 40 citations

Effects of a Competitive Inhibitor (Mevinolin) of 3‐Hydroxy‐3‐methylglutaryl Coenzyme A Reductase on Human and Bovine Endothelial Cells, Fibroblasts and Smooth Muscle Cells in Vitro

1989 • 39 citations

Comparative effects of simvastatin (MK-733) and pravastatin (CS-514) on hypercholesterolemia induced by cholesterol feeding in rabbits

1990 • 36 citations

A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase

1989 • 32 citations

HMG CoA Reductase Inhibitors

1988 • 30 citations

3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors

1994 • 29 citations

Cell‐cycle‐dependent, differential prenylation of proteins

1991 • 28 citations

Influence of mevinolin on experimental atherosclerosis in rabbits

1981 • 27 citations

Dietary and mechanically induced rabbit Iliac-femoral atherosclerotic lesions: A chemical and morphologic evaluation

1991 • 27 citations

Mevinolin, a competitive inhibitor of hydroxymethylglutaryl coenzyme A reductase, suppresses enterocyte esterification of exogenous but not endogenous cholesterol

1992 • 15 citations

The XI international symposium on Drugs affecting lipid metabolism

1985 • 4 citations