Attenuation of diet‐induced atherosclerosis in rabbits with a highly selective 15‐lipoxygenase inhibitor lacking significant antioxidant properties

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Beyond Cholesterol

1989 • 6,533 citations

[6] Statistical analysis of enzyme kinetic data

1979 • 2,002 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Enzyme Kinetics Behavior and analysis of rapid equilibrium and steady state enzyme systems

1975 • 1,447 citations

Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.

1994 • 1,274 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

Malondialdehyde-Altered Protein Occurs in Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

1988 • 757 citations

Detection of activated T lymphocytes in the human atherosclerotic plaque.

1989 • 739 citations

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

1984 • 547 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells.

1995 • 461 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

5-lipoxygenase inhibitory activity of zileuton.

1991 • 409 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

1992 • 382 citations

The antioxidant butylated hydroxytoluene protects against atherosclerosis.

1991 • 362 citations

Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification

1988 • 301 citations

A rapid screening test to determine the antioxidant potencies of natural and synthetic antioxidants

1993 • 298 citations

Mechanisms of copper- and iron-dependent oxidative modification of human low density lipoprotein

1993 • 282 citations

Intact human ceruloplasmin oxidatively modifies low density lipoprotein.

1994 • 265 citations

Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques.

1995 • 247 citations

Quantitative analysis of cholesterol in 5 to 20 μl of plasma

1974 • 247 citations

Oxygenation of biological membranes by the pure reticulocyte lipoxygenase.

1990 • 244 citations

Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages

1991 • 223 citations

Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine.

1992 • 207 citations

Involvement of 15-lipoxygenase in early stages of atherogenesis.

1994 • 196 citations

The mitogenic effect of 15- and 12-hydroxyeicosatetraenoic acid on endothelial cells may be mediated via diacylglycerol kinase inhibition.

1987 • 181 citations

Oxygenation of lipoproteins by mammalian lipoxygenases

1993 • 163 citations

Probucol attenuates the development of aortic atherosclerosis in cholesterol‐fed rabbits

1989 • 142 citations

Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits.

1988 • 135 citations

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

1994 • 132 citations

Activated human monocytes oxidize low-density lipoprotein by a lipoxygenase-dependent pathway.

1990 • 132 citations

Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.

1995 • 130 citations

Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter.

1995 • 128 citations

A comparison of the antiatherogenic effects of probucol and of a structural analogue of probucol in low density lipoprotein receptor-deficient rabbits.

1994 • 116 citations

Enhanced Levels of Lipoperoxides in Low Density Lipoprotein Incubated with Murine Fibroblasts Expressing High Levels of Human 15-Lipoxygenase

1995 • 107 citations

Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.

1992 • 101 citations

Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells.

1990 • 100 citations

The effects of probucol on the progression of atherosclerosis in mature Watanabe heritable hyperlipidaemic rabbits

1991 • 93 citations

Comparative study on the effect of low-dose vitamin E and probucol on the susceptibility of LDL to oxidation and the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.

1994 • 92 citations

Lipoprotein oxidation as a mediator of atherogenesis: insights from pharmacological studies

1995 • 83 citations

Arachidonate 15-lipoxygenase; characteristics and potential biological significance.

1991 • 72 citations

Formation of 15-hydroxyeicosatetraenoic acid (15-HETE) as the predominant eicosanoid in aortas from Watanabe Heritable Hyperlipidemic and cholesterol-fed rabbits

1989 • 72 citations

Oxidation of Low Density Lipoproteins Greatly Enhances Their Association with Lipoprotein Lipase Anchored to Endothelial Cell Matrix

1996 • 61 citations

Treatment of Cholesterol-Fed Rabbits with Dietary Vitamins E and C Inhibits Lipoprotein Oxidation but Not Development of Atherosclerosis

1994 • 61 citations

The induced lipoxygenase in atherosclerotic aorta converts linoleic acid to the platelet chemorepellant factor 13-hode

1989 • 46 citations

Lipoprotein oxidation as a mediator of atherogenesis: insights from pharmacological studies

1995 • 38 citations

15-hydroxyeicosatetraenoic acid stimulates migration of human retinal microvessel endothelium in vitro and neovascularization in vivo

1990 • 36 citations

Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes

1990 • 35 citations

Presence of LDL receptor-related protein/alpha 2-macroglobulin receptors in macrophages of atherosclerotic lesions from cholesterol-fed New Zealand and heterozygous Watanabe heritable hyperlipidemic rabbits.

1994 • 33 citations

Mouse Peritoneal Macrophages Contain Abundant ω-6 Lipoxygenase Activity That Is Independent of Interleukin-4

1996 • 21 citations

Selective conversion and esterification of monohydroxyeicosatetraenoic acids by human vascular smooth muscle cells: Relevance to smooth muscle cell proliferation

1991 • 20 citations

A possible role for 15-lipoxygenase in atherogenesis

1995 • 16 citations

Indications for the presence of circulating peroxidized low density lipoproteins in WHHL rabbits treated with antioxidants

1993 • 11 citations